HANDBOOK OF STEM CELLS. 2ND EDITION

• VOLUME 1: Pluripotent Stem Cells
Chapter 1. Why Stem Cell Research? Advances in the Field
Chapter 2. “Stemness”: Definitions, Criteria, and Standards
Chapter 3. Pluripotential Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges
Chapter 4. Embryonic Stem Cells in Perspective
Chapter 5. The Molecular Circuitry Underlying Pluripotency in Embryonic Stem Cells and iPS Cells
Chapter 6. Molecular Organization of Cells
Chapter 7. Stem Cell Niches
Chapter 8. Mechanisms of Stem Cell Self-Renewal
Chapter 9. Cell Cycle Regulators in Stem Cells
Chapter 10. Cell Fusion and the Differentiated State
Chapter 11. How Cells Change Their Phenotype
Chapter 12. Somatic Cloning and Epigenetic Reprogramming in Mammals
Chapter 13. Engineered Proteins for Controlling Gene Expression
Chapter 14. Differentiation in Early Development
Chapter 15. Developmental Mechanisms of Regeneration
Chapter 16. Primordial Germ Cells in Mouse and Human
Chapter 17. Cell–ECM Interactions in Repair and Regeneration
Chapter 18. Induced Pluripotent Stem Cells
Chapter 19. Feeder-Free and Defined Culture Conditions for hESC Growth
Chapter 20. Isolation and Maintenance of Murine Embryonic Stem Cells
Chapter 21. Isolation and Maintenance of Primate ES Cells
Chapter 22. Embryonic Stem Cells: Derivation and Properties
Chapter 23. Approaches for Derivation and Maintenance of Human ES Cells: Detailed Procedures and Alternatives
Chapter 24. Alternate Sources of Human Embryonic Stem Cells
Chapter 25. Genetic Approaches in Human Embryonic Stem Cells and their Derivatives: Prospects for Regenerative Medicine
Chapter 26. Genetic Manipulation of Human Embryonic Stem Cells
Chapter 27. Homologous Recombination in Human Embryonic Stem Cells
Chapter 28. Derivation and Differentiation of Human Embryonic Germ Cells
Chapter 29. Growth Factors and the Serum-Free Culture of Human Pluripotent Stem Cells
Chapter 30. Feeder-Free Culture
Chapter 31. Surface Antigen Markers
Chapter 32. Lineage Marking
Chapter 33. Genomic Reprogramming
Chapter 34. Microarray Analysis of Stem Cells and Differentiation
Chapter 35. Potential of ES Cell Differentiation Culture for Vascular Biology
Chapter 36. Use of Embryonic Stem Cells to Treat Heart Disease
Chapter 37. Embryonic Stem Cells in Tissue Engineering
Chapter 38. Zebrafish and Stem Cell Research

• VOLUME 2: Adult and Fetal Stem Cells
Chapter 39. The Development of Epithelial Stem Cell Concepts
Chapter 40. Stem Cells Derived from Amniotic Fluid
Chapter 41. Update on “Stem and Progenitor Cells Isolated from Cord Blood”
Chapter 42. Stem Cells in Extraembryonic Lineages
Chapter 43. Mesenchymal Stem Cells in Regenerative Medicine
Chapter 44. Multipotent Adult Progenitor Cells
Chapter 45. Mesenchymal Stem Cells
Chapter 46. Stem Cells Derived from Fat – an Update
Chapter 47. Ontogeny of the Hematopoietic System
Chapter 48. Hematopoietic Stem Cells
Chapter 49. Cell Therapy for Blood Substitutes
Chapter 50. Peripheral Blood Stem Cells
Chapter 51. Human Vascular Progenitor Cells
Chapter 52. Stem Cells and the Regenerating Heart
Chapter 53. Cardiac Stem Cells – Biology and Therapeutic Applications
Chapter 54. Stem Cells and Heart Disease
Chapter 55. Skeletal Muscle Stem Cells
Chapter 56. Stem Cells for the Treatment of Muscular Dystrophy
Chapter 57. Myoblast Transplantation in Skeletal Muscles
Chapter 58. Neurogenesis in the Vertebrate Embryo
Chapter 59. The Nervous System
Chapter 60. Stem Cells in the Adult Brain
Chapter 61. Neural Stem Cells – Therapeutic Applications in Neurodegenerative Diseases
Chapter 62. Spinal Cord Injury
Chapter 63. Sensory Epithelium of the Eye and Ear
Chapter 64. Epithelial Skin Stem Cells
Chapter 65. Regeneration of Epidermis from Adult Human Keratinocyte Stem Cells
Chapter 66. Burns and Skin Ulcers
Chapter 67. Stem Cells in the Gastrointestinal Tract
Chapter 68. Pancreatic Stem Cells
Chapter 69. Adult Progenitor Cells as a Potential Treatment for Diabetes
Chapter 70. Islet Cell Therapy and Pancreatic Stem Cells
Chapter 71. Cell Therapy of Liver Disease: From Hepatocytes to Stem Cells
Chapter 72. Adult Liver Stem Cells
Chapter 73. Cell Lineages and Stem Cells in the Embryonic Kidney
Chapter 74. Orthopaedic Applications of Stem Cells
Chapter 75. Somatic Cells – Growth and Expansion Potential of T Lymphocytes
Chapter 76. Designing Tunable Artificial Matrices for Stem Cell Culture
Chapter 77. Stem Cell Gene Therapy
Chapter 78. Histogenesis in Three-Dimensional Scaffolds
Chapter 79. Stem Cells in Tissue Engineering
Chapter 80. Ethical Considerations
Chapter 81. Stem Cell Research – Religious Considerations
Chapter 82. US Stem Cell Research Policy
Chapter 83. Overview of the FDA Regulatory Process
Chapter 84. It’s Not About Curiosity, It’s About Cures: Stem Cell Research – People Help Drive Progress
Index

New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells & Cell Biology and Adult & Fetal Stem Cells, this work contains contributions from the world’s experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system.

Features:
• Provides comprehensive coverage on this highly topical subject
• Contains contributions by the foremost authorities and premiere names in the field of stem cell research
• Companion website - http://booksite.elsevier.com/9780123859426/ - contains over 250 color figures in presentation format

Authors
• Anthony Atala, Anthony Atala Wake Forest University Department of Urology Winston-Salem, NC.
• Robert Lanza, Advanced Cell Technology, MA, USA