HAPLOIDENTICAL TRANSPLANTATION. CONCEPTS AND CLINICAL APPLICATION

1. Historical Perspective and Current Trends in Haploidentical Transplantation
2. Toward Safer CD34+ Megadose T-Cell-Depleted Transplants Following Reduced Intensity and Nonmyeloablative Conditioning Regimens
3. Selective Allo-depletion: TcRaß and CD19+ T-Cell Depletion
4. Adoptive Immunotherapy with Regulatory and Conventional T-cells in Haploidentical T-cell Depleted Transplantation Protects from GvHD and Exerts GvL Effect
5. Haploidentical Transplantation Using Unmanipulated G-CSF-Primed Blood and Marrow as Allografts: Clinical Data and Challenges
6. Photodepletion to Promote Immune Reconstitution Without Graft-Versus-Host Disease After HLA-Haploidentical Transplantation
7. Post-transplant Cyclophosphamide in Haploidentical Transplantation
8. Graft Source: Marrow or Peripheral Blood with Posttransplant Cyclophosphamide—What Matters?
9. Anti-HLA Antibodies: Assessment and Mitigating Strategies
10. Haploidentical Transplants and NK Cell Alloreactivity
11. Myeloablative Versus Nonmyeloablative Conditioning Regimen in Haploidentical Transplantation: Does It Matter and How Best to Select Between the Two?
12. Haploidentical Transplants for Nonmalignant Diseases in Children
13. Haploidentical Hematopoietic Cell Transplantation in Children with Neoplastic Disorders
14. Haploidentical Transplants: Nonmalignant Diseases in Adults
15. Haploidentical Transplants for Acute Myeloid Leukemia in Adults
16. Haploidentical Hematopoietic Cell Transplantation in Lymphomas
17. Haploidentical Transplants for Myeloproliferative Neoplasms
18. Haploidentical Transplants: Immune Reconstitution With and Without Augmentation Strategies
19. Prevention and Treatment of Relapse After HLA-Haploidentical Hematopoietic Cell Transplantation
20. Unique Complications and Limitations of Haploidentical Hematopoietic Cell Transplant
21. Future Prospects: Haploidentical Transplantation

In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.

Features
• Covers a range of clinically relevant issues in haploidentical transplantation
• Provides practical support for hematologists and transplant physicians
• Draws attention to the results of high-impact clinical trials when available
• Written by renowned experts in the field