HEMOSTASIS AND THROMBOSIS. BASIC PRINCIPLES AND CLINICAL PRACTICE (ONLINE AND PRINT)

Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.

Features
NEW to the Sixth Edition…
- A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.
- Full color throughout
- A companion website that offers full text online and an image bank.
- A new introductory section of chapters on basic sciences as related to the field
- Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.
- Overview chapters preceding each section address broad topics of general importance.

About the Author(s)
Victor J Marder MD, Professor of Clinical Medicine, Director, Vascular Medicine Program, Los Angeles Orthopaedic Hospital/UCLA; Division of Hematology/Medical Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
William C Aird MD, Associate Professor of Medicine, Beth Israel Deaconness Medical Center, Boston, MA
Joel S Bennett MD, Professor of Medicine, University of Pennsylvania, Philadelphia, PA
Sam Schulman MD, Professor of Medicine, McMaster University, Hamilton, Ontario, Canada
Gilbert C White II MD, Executive Vice President for Research, Blood Center of Wisconsin, Milwaukee, WI

Table of Contents
PART I: INTRODUCTION TO THE FIELD OF HEMOSTASIS AND THROMBOSIS
Chapter 1. History of the Field –
Chapter 2. Molecular Evolution of the Vertebrate Blood Coagulation System –
Chapter 3. Molecular and Clinical Genetics –
Chapter 4: Coagulation Enzymology –
Chapter 5: Cell Biology, Protein Processing, and Cell Signaling –
Chapter 6: Cellular and Molecular Immunology –
Chapter 7: Biostatistics and Epidemiology: The Basic Science of Clinical Research –
PART II: BASIC HEMOSTASIS AND THROMBOSIS
SECTION A: COAGULATION & FIBRINOLYSIS
Chapter 8: Overview of Basic Coagulation and Fibrinolysis –
Chapter 9: The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression –
Chapter 10: Genetics of Coagulation Proteins –
Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation –
Chapter 12: Factors V and VIII –
Chapter 13: Structure and Function of von Willebrand Factor –
Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins –
Chapter 15A: Factor XI –
Chapter 15B: The Factor XII-driven Plasma Contact System –
Chapter 16: Fibrinogen Structure and Function –
Chapter 17: Factor XIII –
Chapter 18: Antithrombin and the Serpin Family –
Chapter 19: Protein C and S and Thrombomodulin System –
Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis –
Chapter 21: Inhibitors of Fibrinolysis –
Björn Wiman and Anna Ågren
SECTION B: PLATELET BIOLOGY
Chapter 22: Overview of Platelet Structure and Function –
Chapter 23: Platelet Production: Cellular and Molecular Regulation –
Chapter 24: Megakaryocyte Structure and Platelet Biogenesis –
Chapter 25: Thrombopoietin –
Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V –
Chapter 26B: Major Platelet Glycoproteins: GPIIb/IIIa –
Chapter 27: Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity –
Chapter 28: The Basis for Platelet Adhesion –
Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis –
Chapter 30: Platelets and Collagen –
Chapter 31: Integrin aIIb ß3 and Platelet Aggregation –
Chapter 32: Molecular Basis for Platelet Secretion –
Chapter 33: Platelet Signal Transduction –
Chapter 34: Platelet Prostaglandin Metabolism –
Chapter 35: The Role of Platelets in Blood Coagulation –
Chapter 36: Blood-Borne Microparticles –
SECTION C: VASCULAR BIOLOGY - William C. Aird
Chapter 37: Overview of Vascular Biology –
Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis –
Chapter 39: Rheology and Vessel Wall Stress –
Chapter 40: Nitric Oxide –
Chapter 41: Blood Vessel Wall in Health and Disease –
Chapter 42: Endothelial Cell Function –
Chapter 43: Role of Endothelium in Hemostasis –
Chapter 44: Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway –
Chapter 45: Heparin and Vascular Proteoglycans –
Chapter 46: Endothelial Cell-Blood Cell Interactions –
Chapter 47: Leukocyte Function and Contribution to Disease –
Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction –
Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel
PART III: DISORDERS OF COAGULATION, PLATELETS, AND VESSEL WALL
SECTION A: BLEEDING DISORDERS COAGULATION & FIBRINOLYSIS
Chapter 49: Overview of Inherited Hemorrhagic Disorders –
Chapter 50: Differential Diagnosis of the Bleeding Patient –
Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia –
Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment –
Chapter 53: Rare Inherited Coagulation Disorders Other than Hemophilia –
Chapter 54: Afibrogenemias and Dysfibrogenemias –
Chapter 55: Familial Multiple Coagulation Factor Deficiencies –
Chapter 56: Clinical Disorders of Fibrinolysis –
Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies –
Chapter 58: Laboratory Markers of Coagulation and Fibrinolysis –
SECTION B: ACQUIRED & INHERITED PLATELET DISORDERS
Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders –
Chapter 60: Differential Diagnosis of Thrombocytopenia –
Chapter 61: Immune Thrombocytopenic Purpuraand Posttransfusion Purpura –
Chapter 62: Drug-Induced Thrombocytopenia –
Chapter 63: Inherited Thrombocytopenias –
Chapter 64: Acquired Nonimmune Thrombocytopenia –
Chapter 65: Hereditary Disorders of Platelet Function –
Chapter 66: Acquired Disorders of Platelet Function –