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Anatomía Patológica
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Contributors vii
Preface ix
Tribute xi
Preface to the First Edition (1966) xiii
Acknowledgments xv
• SECTION 1 Introduction to Kidney Pathology 1
1.1Kidney Pathology History and Kidney Biopsy Methods 2
1.2 Primer on the Pathologic Classification and Diagnosis of Kidney Disease 8
• SECTION 2 Kidney Anatomy, Histology, and Development 43
2.1 Kidney Anatomy and Histology 44
2.2 Kidney Development 143
SECTION 3 Kidney Congenital Anomalies and Cystic Diseases 169
3.1 Patterns of Injury, Terminology, and Classification of Kidney Congenital Anomalies and Cystic Diseases 170
3.2 Kidney Congenital Anomalies Including Dysplasia 177
3.3 Cystic Kidney Disease 195
• SECTION 4 Glomerular Disease Associated With Proteinuria and Nephrotic Syndrome 215
4.1 Patterns of Injury, Terminology, and Classification of Glomerular Diseases Associated With Proteinuria and Nephrotic Syndrome 216
4.2 Minimal Change Disease 234
4.3 Focal Segmental Glomerulosclerosis 275
4.4 Membranous Nephropathy 334
4.5 Amyloidosis 391
4.6 Monoclonal Immunoglobulin-Related Glomerular Disease 424
4.7 Immunotactoid Glomerulopathy 466
4.8 Diabetic Kidney Disease 477
4.9 Idiopathic Nodular Glomerulosclerosis 518
4.10 Metabolic and Storage Disease Glomerulopathies 526
4.11 Fibronectin Glomerulopathy 560
4.12 Collagenofibrotic Glomerulopathy and Nail-Patella Syndrome 567
• SECTION 5 Glomerular Disease Associated With Hematuria and Nephritic Syndrome 577
5.1 Patterns of Injury, Terminology, and Classification of Glomerular Diseases Associated With Hematuria and Nephritic Syndrome 578
5.2 IgA Nephropathy and IgA Vasculitis (Henoch-Schönlein Purpura) Nephritis 591
5.3 Lupus Nephritis and Related Autoimmune Diseases 661
5.4 Fibrillary Glomerulonephritis 740
5.5 Cryoglobulinemic Glomerulonephritis 750
5.6 Acute Post-infectious Glomerulonephritis and Infection-Associated Glomerulonephritis 763
5.7 C3 Glomerulopathy 823
5.8 Anti–Glomerular Basement Membrane Disease 848
5.9 Antineutrophil Cytoplasmic Autoantibody Disease 874
5.10 Alport Syndrome/Type IV Collagen Nephropathies 903
• SECTION 6 Kidney Vasculopathies 923
6.1 Patterns of Injury, Classification, and Diagnostic Algorithm of Kidney Vasculopathies 924
6.2 Kidney Disease Related to Hypertension and Age 937
6.3 Fibromuscular Dysplasia 967
6.4 Thrombotic Microangiopathies 973
6.5 Preeclampsia and Other Pregnancy-Associated Kidney Disease 1033
6.6 Disseminated Intravascular Coagulation 1068
6.7 Atherosclerosis and Embolic Kidney Disease 1071
6.8 Polyarteritis Nodosa, Kawasaki Disease, Takayasu Arteritis, and Giant Cell Arteritis 1078
• SECTION 7 Tubulointerstitial Disease 1107
7.1 Patterns of Injury, Terminology, and Classification of T ubulointerstitial Disease 1108
7.2 Infection-Related T ubulointerstitial Nephritis 1122
7.3 Noninfectious T ubulointerstitial Nephritis 1168
7.4 IgG4-Related Disease 1204
7.5 Chronic Interstitial Nephritis in Agricultural Communities (Mesoamerican Nephropathy, CKDu) and Aristolochic Acid Nephropathy (Balkan Endemic Nephropathy) 1216
7.6 Nephronophthisis, Medullary Cystic Disease, and Other Genetic T uvular Disease 1232
7.7 Ischemic and Septic Acute T ubular Injury and Cortical Necrosis 1262
7.8 Nephrotoxic Acute T ubular Injury 1284
7.9 Light Chain Tubulopathies 1310
7.10 Light Chain (Myeloma) Cast Nephropathy and Mimics 1317
7.11 Myoglobin, Hemoglobin, and Bile Cast Nephropathies, and Anticoagulant Nephropathy 1329
7.12 Nephrolithiasis and Crystallopathies 1344
7.13 Obstructive and Reflux Nephropathy 1366
• SECTION 8 Transplant Pathology 1383
8.1 Patterns of Injury, Terminology, and Classification of Kidney T ransplant Disease 1384
8.2 Kidney Allograft Biopsy: Overview 1393
8.3 Donor Kidney Biopsies 1396
8.4 Kidney Transplant Rejection 1402
8.5 Kidney T ransplant Ischemic Injury 1479
8.6 Kidney T ransplant: Drug T oxicity 1485
8.7 Kidney Transplant Infection 1501
8.8 Recurrent and De Novo Disease 1521
8.9 Posttransplant Lymphoproliferative Disorders 1537
8.10 Kidney T ransplant: Surgical and Vascular Complications 1545
• SECTION 9 Kidney Neoplasms 1551
9.1 Patterns of Injury, Terminology, and Classification of Kidney Neoplasms 1552
9.2 Kidney Neoplasms in Children 1558
9.3 Kidney Neoplasms in Adults 1567
Index 1601

For nearly 60 years, Heptinstall’s Pathology of the Kidney has been the reference of choice for both pathologists and nephrologists for expert, authoritative coverage of kidney disease. The fully revised and reorganized Eighth Edition, edited by Drs. J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo, Volker Nickeleit and Michael Barry Stokes offers thorough pathologic descriptions, important clinical correlations, and up-to-date discussions of causes and pathogenesis to improve understanding of kidney disease and to facilitate accurate diagnosis and optimum care of patients with kidney disease. Now in a single volume, this image-rich text conveys the unique challenges and intricacies of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research.
• Features a completely reorganized, single volume format, with more than 60 concise chapters covering all kidney diseases
• Provides comprehensive yet concise information on pathology, differential diagnosis and clinicopathologic correlations, as well as useful overviews of pathogenesis, demographics/epidemiology, and relevant clinical presentation, treatment, and outcomes
• Contains numerous diagnostic algorithms throughout
• Offers clinically oriented, quick-reference content on patterns of injury and classification

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• J. Charles Jennette MD. Professor of Medicine, Chair of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC
• Vivette D. D'Agati MD. Professor of Pathology; Director, Division of Renal Pathology, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York