HEREDITARY COLORECTAL CANCER. GENETIC BASIS AND CLINICAL IMPLICATIONS. GENETIC BASIS AND CLINICAL IMPLICATIONS

1. Lynch Syndrome
2. The Molecular Basis of Lynch-like Syndrome
3. Constitutional Mismatch Repair Deficiency
4. Mismatch Repair-Proficient Hereditary Nonpolyposis Colorectal Cancer
5. Genetic and Environmental Modifiers of Cancer Risk in Lynch Syndrome
6. Adenomatous Polyposis Syndromes: Introduction
7. Familial Adenomatous Polyposis or APC-Associated Polyposis
8. Adenomatous Polyposis Syndromes: Polymerase Proofreading-Associated Polyposis
9. Adenomatous Polyposis Syndromes: MUTYH-Associated Polyposis
10. Adenomatous Polyposis Syndromes: NTHL1-Associated Polyposis / Tumor Syndrome
11. Adenomatous Polyposis Syndromes: Germline Biallelic Inactivation of Mismatch Repair Genes
12. Adenomatous Polyposis Syndromes: Unexplained Colorectal Adenomatous Polyposis
13. Hamartomatous Polyposis Syndromes
14. Hereditary Mixed Polyposis Syndrome
15. Serrated Polyposis Syndrome
16. Genetic Testing in Hereditary Colorectal Cancer
17. Universal Tumor Screening for Lynch Syndrome
18. Classification of Genetic Variants
19. Prediction Models for Lynch Syndrome
20. Surveillance Guidelines for Hereditary Colorectal Cancer Syndromes
21. Surgical Management of Hereditary Colorectal Cancer Syndromes
22. Chemoprevention in Hereditary Colorectal Cancer Syndromes
23. The Immune Biology of Microsatellite Unstable Cancer
24. Hereditary Colorectal Cancer: Immunotherapy Approaches
25. Medical Oncology Management of Hereditary Colorectal Cancer
26. Databases: Intentions, Capabilities, and Limitations
27. The Colon Cancer Family Registry Cohort
28. The Prospective Lynch Syndrome Database
29. The InSiGHT Database: An Example LOVD System
30. The International Mismatch Repair Consortium

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed.
This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

Features
• Comprehensive and updated coverage of the topic
• Novel findings and challenges discussed
• Provides coverage of issues ranging from genetics to clinical description of the syndromes

Author
Laura Valle, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Av. Gran Via 199-203, 08908Barcelona, SpainProf. Dr. Stephen Gruber, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, USADr. Gabriel Capella, Institut Català d'Oncologia (ICO), Av. de la Granvia de l'Hospitalet 199, 08907 Barcelona, Spain