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Hirschsprung’s Disease: A Historical Perspective
Development of the Enteric Nervous system
Functional Anatomy of the Enteric System
Normal Colonic Morphology and Motor Function
Animal Models of Hirschsprung’s Disease
Familial Hirschsprung’s Disease
Genetics of Hirschsprung’s Disease
Stem cell Therapy for Enteric neuropathies
Pathophysiology of Hirschsprung’s Disease
Epidemiology and Clinical Characteristics of Hirschsprung’s Disease
Associated Anomalies and Syndromes in Hirschsprung’s Disease
Association between Hirschsprung’s Disease and Multiple Endocrine Neoplasia Type 2a
Hirschsprung’s Associated Enterocolitis
Radiological Diagnosis of Hirschsprung’s Disease
Manometeric Diagnosis of Hirschsprung’s Disease
Rectal Biopsy for the diagnosis of Hirschsprung’s Disease
Histopathological Diagnosis of Hirschsprung’s Disease
Total Colonic Aganglionosis
Hirschsprung’s Disease in adolescents and adults
Variants of Hirschsprung’s Disease
Megacystis-Microcolon-Intestinal Hypoperistalsis syndrome
Degenerative Hollow Visceral Myopathy Mimicking Hirschsprung’s Disease
Transanal Pull-Through operation for rectosigmoid Hirschsprung’s Disease
Laparoscopically Assisted Pull-Through operation for Hirschsprung’s Disease
Redo Surgery for Hirschsprung’s Disease
Early and late Complications following Pull-Through operation for Hirschsprung’s Disease
Morphological Basis of Persistent bowel problems following a properly performed pull-through operation for Hirschsprung’s Disease
Bowel Management for the treatment of Chronic constipation and soiling in patients operated for Hirschsprung’s Disease
Inflammatory Bowel Disease in patients with Hirschsprung’s Disease
Intestinal Transplantation for Total Intestinal Aganglionosis
Urological and Sexual outcome in patients with Hirschsprung’s Disease
Longterm Outcome and Quality of life after treatment of Hirschsprung’s Disease.

The fourth edition of this leading book provides an authoritative, comprehensive and complete account of the neuronal disorders of the lower gastrointestinal tract in children. The book has been thoroughly revised and updated to reflect major advances that have occurred both in the understanding as well as the treatment of Hirschsprung’s disease.
Contents discuss the latest therapies such as stem cell therapies, the epidemiology and association with multiple endocrine neoplasia and approaches to diagnosis such as radiology and manometry as well as Hirschsprung’s disease in adolescents and adults.
Surgical approaches are thoroughly covered and include a new chapter on intestinal transplantation options. The follow-up care and long-term outcomes of patients who have undergone therapy are also addressed in this edition.
With several new chapters added and the contents updated and re-worked, this edition is authored by the leading current experts in their respective fields. It is a must-have book for pediatric surgeons, pediatricians, gastroenterologists, and colorectal surgeons.

• Fourth fully revised edition of key book in the field
• Offers the latest perspectives and therapies
• Discusses long-term surgery outcomes

Professor Prem Puri ,MBBS, LRCP, LRCS(Ed), DCH, MS, FRCS, FRCS(Ed),FACS, FC Paed Surg(SA)(Hon), FAAP(Hon), D.Sc(Hon) is the Newman Clinical Research Professor at the University College Dublin School of Medicine and Medical Science and Consultant Paediatric Surgeon at the Beacon Hospital. He is currently the President of the World Federation of Associations of Paediatric Surgeons (WOFAPS) FOUNDATION and Secretary of the International Board of Pediatric Surgical Research. He is Past President of the World Federation of Associations of Pediatric Surgeons (WOFAPS), and Past President of the European Paediatric Surgeons Association (EUPSA). He is Editor-in-Chief of Paediatric Surgery International, and also on the Editorial Board of several other journals. He was the Director of Research at the National Children’s Research Centre (NCRC), Dublin, Ireland from 1989–2009 and President of the NCRC from 2009–2016.
He has been awarded many Honorary Fellowships, including the American Surgical Association (ASA), American Academy of Paediatrics, American Paediatric Surgical Association, Canadian Association of Pediatric Surgeons, Japanese Society of Pediatric Surgeons, and also Argentinean, Austrian, Canadian, Czech, Croatian, Cuban, Indian, South African and Ukrainian paediatric surgical associations.
Professor Puri is known internationally for his research into underlying mechanisms causing birth defects, and innovative treatments, which have benefited children all over the world. He is a multi award-winning researcher whose previous awards include People of the Year Award (Highest Irish National Award), the prestigious Denis Browne Gold Medal by the British Association of Paediatric Surgeons and Rehbein Medal by the European Paediatric Surgeons Association for outstanding contribution to paediatric surgery. He has been a visiting professor to many leading universities all over the world, and invited speaker at over 250 international scientific meetings. He has published 10 books, 147 chapters in textbooks and over 700 articles in peer-reviewed journals. He is the Editor of Newborn Surgery regarded as the authoritative book in the field, and the 4th edition is now published, and also of the widely acclaimed Pediatric Surgery (Atlas Series) which is in its 2nd edition. His research has been cited over 20,000 times in peer-reviewed articles.

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