HISTAMINE RECEPTORS. PRECLINICAL AND CLINICAL ASPECTS

1. Molecular Aspects of Histamine Receptors
2. Genetic Polymorphisms in the Histamine Receptor Family
3. The Role of Histamine H4 Receptor in Asthma and Atopic Dermatitis
4. Identification and Roles of Zebrafish Histamine Receptors
5. Histamine H3R Antagonists: From Scaffold Hopping to Clinical Candidates
6. Clinical Significance of Histamine H1 Receptor Gene Expression and Drug Action of Antihistamines
7. Histamine and Its Receptors as a Module of the Biogenic Amine Diseasome
8. Histaminergic Regulation of Blood–Brain Barrier Activity
9. Histamine Function in Nervous Systems
10. Heterogeneity of Histaminergic Neurons
11. Modulation by Histamine H3 Receptors of Neurotransmitter Release in the Basal Ganglia
12. Interaction of Brain Histaminergic and Dopaminergic Systems
13. Histamine H1 Receptor Occupancy in the Human Brain Measured by Positron Emission Tomography
14. Modulation of Memory Consolidation, Retrieval and Extinction by Brain Histamine
15. Histamine and Appetite

A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.

Features
• Comprehensive overview of the role of histamine in homeostasis and behavior
• Capitalizes on new approaches in the field of histamine research
• Examines the most clinically relevant recent discoveries