HOFFBRAND'S POSTGRADUATE HAEMATOLOGY, 8TH EDITION

About the Editors viii
Contributor’s List x
Preface to the eighth edition by xiv
Preface to the eighth edition by xv
Preface to the first edition xvi
About the companion website xvii
• Part I General principles of haematology 1
1 Human stem cells and haemopoiesis 3
2 Phagocytes 15
3 Erythropoiesis in the human 43
4 Lymphocyte development and function 56
5 The spleen 71
6 Cancer immunotherapy 82
7 Clinical applications of gene editing and therapy 96
8 Application of next-generation sequencing in haematology 106
9 The molecular basis of haematological malignancies 121
10 Laboratory diagnosis of haematological neoplasms 142
• Part II Red blood cell disorders and blood transfusion 163
11 Iron metabolism iron deficiency and disorders of haem synthesis 165
12 Iron overload 188
13 Megaloblastic anaemia 201
14 Haemoglobin and the inherited disorders of globin synthesis 222
15 Sickle cell disease 249
16 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 269
17 Acquired haemolytic anaemias 292
18 Red cell immunohaematology 309
19 Clinical blood transfusion 328
• Part III Lymphoid disorders 361
20 The classification of lymphomas 363
21 Adult acute lymphoblastic leukaemia 395
22 Childhood acute lymphoblastic leukaemia 409
23 Chronic lymphocytic leukaemia and other chronic B-cell lymphoproliferative disorders 428
24 T-cell lymphoma and lymphoproliferative disorders 452
25 Hodgkin lymphoma 468
26 Indolent non-Hodgkin lymphomas 482
27 Aggressive B-cell non-Hodgkin lymphoma 501
28 Multiple myeloma 524
29 Amyloidosis 547
• Part IV Stem cell and myeloid disorders 561
30 Inherited aplastic anaemia/bone marrow failure syndromes 563
31 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 583
32 Acute myeloid leukaemia 605
33 Chronic myeloid leukaemia 630
34 The myelodysplastic syndromes 652
35 Myeloproliferative neoplasms 673
36 Macrophages dendritic cells and histiocytic disorders 704
37 Stem cell transplantation 719
38 Clonal haematopoiesis 745
• Part V Haemostasis and thrombosis 757
39 Normal haemostasis 759
40 The vascular function of platelets 782
41 Haemophilia and von Willebrand disease 798
42 Rare inherited coagulation disorders 819
43 Acquired coagulation disorders 829
44 Congenital platelet disorders 848
45 Primary immune thrombocytopenia 861
46 Thrombotic thrombocytopenic purpura (congenital and acquired) and haemolytic–uraemic syndrome 872
47 Antithrombotic agents 886
48 Pathogenesis of venous thromboembolism 902
49 Prevention and management of venous thromboembolism 921
50 Pathogenesis and management of arterial thrombosis 932
• Part VI Consultative haematology supportive care and miscellaneous disorders 947
51 Haematological aspects of conditions that occur primarily in tropical countries 949
52 Lysosomal storage disorders 966
53 Obstetric haematology 974
54 Neonatal haematology 989
55 Supportive care in the management of leukaemia 1005
56 General consultative haematology 1024
57 Consultative haemostasis and thrombosis 1036
Index 1055

The latest edition of the key haematology text
Haematology, the study and treatment of blood and bone marrow disorders, is a rich and complex discipline that consistently produces cutting-edge medical research. Since 1972, Hoffbrand’s Postgraduate Haematology has acted as the foundational overview and reference text for this subject, introducing generations of trainees and medical residents to the pathogenesis, clinical and laboratory features, and management of blood disorders.
The eighth edition of Hoffbrand’s Postgraduate Haematology, now with a new editorial team including leading clinicians and researchers, promises to continue this tradition of excellence with a fully updated text. Lavishly illustrated, comprehensive, and thoughtfully referenced, it is an indispensable resource.
Readers of the eighth edition of Hoffbrand’s
Postgraduate Haematology will also find:
• Four-color illustrations and photomicrographs of blood cells and tissues throughout to support key topics
• New sections analysing recent advances in next generation sequencing, genome editing, clonal haematopoiesis, anticoagulant drugs, diagnostic laboratory tools, and more
• Companion website with downloadable figures and other tools

Hoffbrand’s Postgraduate Haematology is ideal for all postgraduate trainees or residents in haematology, as well as for clinicians and practitioners looking for a reference work on the subject and a guide to the latest research.