HUMAN PRION DISEASES. VOLUME 153

Section I: Pathophysiology of prions
2. The cellular and pathological prion protein
3. Cell biology of prion infection
4. Experimental models of human prion diseases and prion strains
5. The role of the immune system in prion infection

Section II: Animal prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes)
6. Typical and atypical scrapie
7. Typical and atypical BSE
8. Chronic Wasting Disease

Section III: Human prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes)
9. Sporadic Creutzfeldt-Jakob Disease
10. Variably protease-sensitive prionopathy
11. Variant Creutzfeldt-Jakob Disease
12. Iatrogenic Creutzfeldt-Jakob Disease
13. Genetic Creutzfeldt-Jakob Disease
14. Gerstmann-Sträussler-Scheinker disease
15. Sporadic and fatal Familial Insomnia

Section IV: Prion-like mechanisms in other neurodegenerative diseases
16. Prion-like mechanisms in Alzheimer
17. Prion-like mechanisms in Parkinson
18. Prion-like mechanisms in ALS

Section V: Diagnosis and treatment
19. Prion protein amplification techniques
20. Differential diagnosis with other rapid progressive dementias
21. Symptomatic treatment, care and support of CJD patients
22. Identifying therapeutic targets and treatment in model systems
23. Vaccination strategies
24. Clinical trials

Section VI: Public health issues
25. Animal diseases and the zoonotic potential
26. Safety of blood, blood derivatives and plasma-derived products
27. Safety in clinical practice
28. Concluding thoughts

• Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms
• Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans
• Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Author
• Maurizio Pocchiari, Professor and Director of Research, Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita (ISS), Rome, Italy
• Jean Manson, Professor and Head, Neurobiology Division, The Roslin Institute, University of Edinburgh, UK