IMMUNE BIOLOGY OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION. MODELS IN DISCOVERY AND TRANSLATION. 2ND EDITION

1. Overview
2. HLA system
3. Minor Ag
4. In vivo imaging
5. Engraftment, graft rejection and graft failure
6. Immune regeneration or immune recovery
7. Tumor associated antigens
8. Genetically engineered T cell therapies and immune system engagers for GVHD and GvL
9. Microbiome
10. micro-RNA and kinase regulatory mechanisms and pathways in GVHD
11. APC
12. Costimulation vs. Inhibition
13. Th1/2 & TC1/2
14. Treg
15. Th17
16. B and T cells in chronic GVHD
17. NK
18. Cytokines
19. Chemokines
20. Metabolism and intracellular sensor
21. Omics
22. Endothelium and stroma
23. Future

• Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to bedside
• Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models
• Categorizes published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Authors
• Gerard Socie, Department Head, Transplantation Program AP-HP, Hospital Saint Louis, Paris CEDEX 10, France University Paris VII Denis Diderot.
• Robert Zeiser, Heisenberg Professor and Consultant Physician, Department of Hematology and Oncology, University Medical Center Freiburg, Germany.
• Bruce R. Blazar, Regents Professor and CCRF Chair in Pediatric Oncology, Chief, Pediatric Blood and Marrow Transplantation Program, Director, Clinical and Translational Science Institute, Associate Vice President for Clinical and Translational Science, AHC, Vice Dean for Clinical Investigation, University of Minnesota School of Medicine, USA