IMMUNOMIC DISCOVERY OF ADJUVANTS AND CANDIDATE SUBUNIT VACCINES. IMMUNOMICS REVIEWS:, VOL. 5

1 Immunomic Discovery of Adjuvants, Delivery Systems,
and Candidate Subunit Vaccines: A Brief Introduction
Darren R. Flower and Yvonne Perrie
2 Bacterial Genomes and Vaccine Design
Valeria Cafardi, John L. Telford, and Davide Serruto
3 Identification of Candidate Vaccine Antigens In Silico
Darren R. Flower, Matthew N. Davies, and Irini A. Doytchinova
4 Post-genomic Antigen Discovery: Bioinformatical Approaches
to Reveal Novel T Cell Antigens of Mycobacterium bovis
Martin Vordermeier, Gareth J. Jones, Samantha Sampson,
and Stephen V. Gordon
5 Genome-Based Computational Vaccine Discovery by Reverse
Vaccinology
Yongqun He
6 Computational Prediction of Protein Subcellular Localization,
Genomic Islands, and Virulence to Aid Antigen Discovery
Bhavjinder K. Dhillon, Nancy Y. Yu, and Fiona S.L. Brinkman
7 On the Development of Vaccine Antigen Databases: Progress,
Opportunity, and Challenge
Hifzur Rahman Ansari, Darren R. Flower, and Gajendra P.S. Raghava
8 What Have Dendritic Cells Ever Done for Adjuvant Design?
Cellular and Molecular Methods for the Rational Development
of Vaccine Adjuvants
Alexander D. Edwards
9 Towards the Systematic Discovery of Immunomodulatory
Adjuvants Darren R. Flower
vii10 Designing Liposomes as Vaccine Adjuvants
Malou Henriksen-Lacey and Yvonne Perrie
11 Designing Nonionic Surfactant Vesicles for the Delivery of
Antigens for Systemic and Alternative Delivery Routes
Jitinder Wilkhu, Anil Vangala, Afzal R. Mohammed, and Yvonne Perrie
12 Immune Stimulating Complexes (ISCOMs) and Quil-A Containing
Particulate Formulations as Vaccine Delivery Systems
S. Hook and T. Rades
13 Formulation and Characterisation of PLGA Microspheres as
Vaccine Adjuvants
Daniel J. Kirby, Randip Kaur, and Yvonne Perrie
14 Powder Vaccines for Pulmonary Delivery
Tom Jin and Eric Tsao
About the Authors
Index

- Will address an important emergent area within immunomics: adjuvants
- Explores ways to make vaccines more effective
- There is no such book like this one
Vaccine discovery is one of the most exciting and fast-moving areas of applied science. Since Edward Jenner’s work in the 18th century, vaccines have transformed health across the globe. Bringing together clinical, experimental, and computational disciplines vaccinology addresses the most pressing needs of 21st century health-care: the great infectious diseases threatening the developing world, such as HIV, Malaria, and TB; and chronic diseases, such as dementia, threatening the developed world.

This volume seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.
Content Level » Research

Keywords » Adjuvants - Antigens - Immunomics - Reverse Vaccinology

Related subjects » Immunology - Medical Microbiology - Pharmacology & Toxicology - Systems Biology and Bioinformatics

Dr. Darren R Flower. An interdisciplinary scientist, with special interest in bioinformatics, computational chemistry, and cheminformatics, Dr. Flower has wide-ranging experience of the pre-clinical research environment in both academia and the pharmaceutical industry. Before joining Aston University as a Reader, Dr. Flower was a Jenner Research Fellow and Principal Investigator at the University of Oxford; and formerly a Senior Group Leader managing a large research group at The Edward Jenner Institute for Vaccine Research. Before that, Dr. Flower was a drug discovery scientist in the Pharmaceutical industry. Dr. Flower is a Fellow of the Royal Society of Chemistry, and the author of over 150 research papers and reviews, and 7 Books, including the monograph: Bioinformatics for Vaccinology.

Professor Yvonne Perrie is Pharmacist whose research focuses on the development on delivery systems for drugs and vaccines. Prof. Perrie is currently Head of Pharmacy and Chair in Drug Delivery within Aston University. Prof. Perrie received her Ph.D. from the University of London, UK where she investigated the use of liposomes for gene delivery under the supervision of Professor Gregory Gregoriadis. Prof. Perrie then joined a newly established Drug Delivery Company, Lipoxen Technologies Ltd., prior to taking her post at Aston University. Prof. Perrie is currently Chair of the UK and Ireland Controlled Release Society and has approximately 100 research papers and reviews focusing on the research and development of drug delivery systems.