IMMUNOTHERAPY IN TRANSLATIONAL CANCER RESEARCH

1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer, 1
2 Monoclonal Antibody Therapy, 12
3 Somatic Mutations and Immunotherapy, 24
4 Checkpoint Blockade, 37
6 Cancer Vaccines for Solid Tumors, 72
7 Immunotherapy with Non–Genetically Modified T Cells, 91
8 Immunotherapy with Genetically Modified T Cells, 101
9 Immunomodulation with Adjuvants and Cytokines, 115
10 Immune Cell Migration in Cancer and Immunotherapy, 132
11 Repurposing of Drugs for Immunotherapy, 143
12 Immunomodulation with Radiation, 161
13 Good Manufacturing Practices Facilities for Cellular Therapy, 177
14 T Cell Receptor Mimic Antibodies, 186
15 Stem Cell Transplantation for Treatment of Malignancy, 201
16 Natural Killer Cell–Based Immunotherapy, 215
17 Immunologic Monitoring in Immuno�] Oncology, 228
18 Cell�]Based Therapies for Canine Cancer, 252
19 Interaction between Targeted Therapy and Immunotherapy, 268
Index 286

A guide to state-of-the-art cancer immunotherapy in translational cancer research
A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues.
Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and:
• Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care
• Filled with the concepts, examples, and approaches for developing individualized therapy
• Explores the breath of treatments that reflect the complexity of the immune system itself
• Includes contributions from a panel international experts in the field of immunotherapy

Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Authors
• Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA.
• Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
• Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA.
• Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.