INFLAMMATION, OXIDATIVE STRESS, AND CANCER: DIETARY APPROACHES FOR CANCER PREVENTION

• Section I: Inflammation, Oxidative Stress, Nutritional Phytochemicals, and Cancer
Overview on Oxidative Stress, Inflammation, Cancer Initiation/Progression, and How to Prevent Carcinogenesis/Cancer
Overview of Obesity, Inflammation, and Cancer
Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models: Mechanisms of Carcinogenesis and Prevention
Overview of Common Dietary Phytochemicals Possessing Antioxidant Properties through Nrf2
• Section II: Signal Transduction, Molecular Targets, and Biomarkers of Dietary Cancer-Preventive Phytochemicals
Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals
Biomarkers for Diet in Cancer Prevention Studies
• Section III: In Vivo Absorption and Pharmacokinetics of Nutritional Phytochemicals
Metabolism and Transport of Anticancer and Anti-Inflammatory Phytochemicals across the Gastrointestinal Tract
Pharmacokinetics of Dietary Isothiocyanates and Flavonoids
• Section IV: Vitamins A, D, and E Cancer Prevention, and Clinical Perspective
Retinoic Acid Signaling in Hematopoiesis and Immune Functions, and Options for Chemoprevention
Vitamin D and Inflammation in Cancer: Emerging Concepts
Vitamin E Family of Compounds and Cancer Prevention
The Protective Role of Vitamin E in Inflammation and Cancer
Vitamin D and Cancer: Research Update and Clinical Recommendations
• Section V: Omega-3 and Omega-6 Fatty Acids
Plant and Marine Sources of Omega-3 Polyunsaturated Fatty Acids, Inflammation, and Cancer Prevention
Polyunsaturated Fatty Acids and Cancer Prevention
Anti-Inflammatory and Proresolving Effects of Docosahexaenoic Acid: Implications for Its Chemopreventive Potential
• Section VI: Flavonoids and Polyphenols
Green Tea and Cancer Prevention
Curcumin from Turmeric Spice, Anti-Inflammatory and Antioxidant Phytochemical, and Cancer Prevention
Flavonoids: Impact on Prostate Cancer and Breast Cancer
Cancer Prevention by Isoflavone
Anti-Inflammatory Efficacy of Silibinin: Role in Cancer Chemoprevention
Cancer Prevention by Antioxidant Compounds from Berries
• Section VII: Garlic Organosulfur Compounds and Crucifer Glucusinolates
Garlic and Cancer Prevention
Molecular Mechanisms of Cancer Chemoprevention with Benzyl Isothiocyanate
Suppression of Prostate Carcinogenesis by Dietary Isothiocyanates
• Section VIII: Selenium, Herbal Medicines, Alpha Lipoic Acid, and Cancer Prevention
Cancer Prevention with Selenium: Costly Lessons and Difficult but Bright Future Prospects
Chemoprevention of Lung Cancer by Ginseng
Anti-Inflammatory Botanical Dietary Supplements for Women’s Health: Role in Breast Cancer Prevention?
PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different Tissues
Lipoic Acid in the Prevention and Treatment of Inflammatory Disease and Cancer
• Section IX: Epigenetics and Chronic Inflammation
Epigenetic Modifications by Dietary Phytochemicals in Cancer Prevention
Nutritional Phytochemicals and the Management of Chronic Inflammation

Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals.

Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics.

The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

Features
• Presents current understanding on diet, oxidative stress, inflammation, and cancer
• Examines various types of promising nutritional phytochemicals—from in vitroand in vivo studies to clinical studies
• Connects biomarkers, metabolites, and biological activities of the nutritional phytochemicals to the prevention of diseases
• Offers the first of its kind in a book that provides the key mechanistic understanding of the impact of diet on oxidative stress, inflammation, and cancer
• Covers dietary and herbal cancer-preventive compounds, such as vitamins D and E, green tea, curcumin, berries, garlic, selenium, ginseng, flaxseed oil, and fish oil
• Discusses research on epigenetics modification in cancer prevention

Author
Ah-Ng "Tony" Kong, Ph.D., is a distinguished professor (PII), Glaxo Endowed Chair Professor of Pharmaceutics, and director of the Graduate Program in Pharmaceutical Sciences at Rutgers, the State University of New Jersey. He is also the director for the Center for Pharmacogenetics and Pharmacogenomics at Rutgers University. Dr. Kong has published more than 200 original research papers, review articles, and book chapters. He has chaired and given presentations in many national and international symposia and conferences and is currently serving on the board of 15 international journals. His research areas are in dietary phytochemicals (signaling and gene expression, nutrigenomics, cancer chemoprevention); animal tumor models of the prostate, colon, and skin; epigenetics/epigenomics; oxidative/redox/inflammatory stress response; Nrf2-mediated nuclear transactivation and signaling; and pharmacokinetics and pharmacodynamics of phytochemicals.