INTRAPERITONEAL CANCER THERAPY. PRINCIPLES AND PRACTICE

PERITONEUM: EMBRYOLOGY, ANATOMY, AND PHYSIOLOGY
Embryology and Anatomy of the Peritoneal Cavity
Structure and Function of the Mesothelial Cell
Applied Radiological Anatomy of the Peritoneal Cavity
Peritoneal Drug Transport
PERITONEAL CARCINOMATOSIS: BASIC MECHANISMS
Molecular Biology of Peritoneal Carcinomatosis
Dissemination and Adhesion of Peritoneal Cancer Cells to the Peritoneal Wall
Genomic Approaches to Peritoneal Carcinomatosis
Surgery, Wound Healing, and Peritoneal Minimal Residual Disease in Colorectal Cancer
Role of the Greater Omentum in the Pathogenesis of Peritoneal Carcinomatosis
Lymphatic Transport and the Diaphragmatic Stomata
INTRAPERITONEAL DRUG THERAPY: BASIC PRINCIPLES
Pharmacokinetics of Intraperitoneal Cytotoxic Drug Therapy
Tissue Transport and Pharmacodynamics of Intraperitoneal Chemotherapy
Mathematical Models of Intraperitoneal Drug Delivery
SURGICAL TECHNIQUES FOR INTRAPERITONEAL DRUG DELIVERY
Management of Peritoneal Metastases Using Cytoreductive Surgery and Perioperative Chemotherapy
Chemoperfusion Techniques and Technologies
Port Placement for Intraperitoneal Chemotherapy
CLINICAL RESULTS OF INTRAPERITONEAL DRUG DELIVERY
Intraperitoneal Chemotherapy for Ovarian Cancer
Cytoreductive Surgery and HIPEC in the Treatment of Advanced Epithelial Ovarian Cancer and Serous Papillary Peritoneal Carcinoma
Pseudomyxoma Peritonei
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer with Peritoneal Surface Disease
Diffuse Malignant Peritoneal Mesothelioma: Current Concepts in Evaluation and Management
Gastric Cancer and Intraperitoneal Chemotherapy
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma
Peritoneal Surface Malignancy from Neuroendocrine Tumors
Treatment Considerations for High-Grade Appendiceal Adenocarcinoma
Systemic Therapy for Appendiceal Cancer
Toxicity and Morbidity of IP Drug Therapy
Safety Considerations and Occupational Hazards
Role of CRS/HIPEC in the Management of Malignant Ascites
NOVEL AND EXPERIMENTAL APPROACHES
Development of Drug-Loaded Particles for Intraperitoneal Therapy
Biomaterials and Drug Delivery Systems for Intraperitoneal Chemotherapy
Intraperitoneal Nonviral Nucleic Acid Delivery in the Treatment of Peritoneal Cancer
Immunotherapy of Peritoneal Carcinomatosis
The Promise of Oncolytic Viral Therapy for the Treatment of Peritoneal Surface Malignancies
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)

• Encompasses all aspects from basic science (anatomy and physiology) to clinical aspects of diagnosis and treatment of peritoneal cancer
• Features editors who are leading figures in the field of intraperitoneal cancer with chapters contributed by an international team of experts from North America, Europe, and elsewhere
• Discusses the latest advances in the rapidly growing field of intraperitoneal cancer therapy
• Appeals both to clinical oncologists (surgical, gynecological, and medical) and researchers seeking a reliable and up-to-date reference

Summary
Intraperitoneal Cancer Therapy: Principles and Practice is one of the first books to combine the latest clinical developments in the treatment of patients with peritoneal surface disease and the scientific principles that underlie the concept of intraperitoneal cancer therapy.
The book covers basic concepts such as anatomy, physiology, pharmacology, and mathematical models of drug transport as well as practical clinical applications, highlighted with results from clinical trials and promising novel preclinical developments.
The book is a state-of-the-art reference for surgical and medical oncologists interested in the treatment of carcinomatosis. It also establishes and promotes basic and translational research interest in the field of intraperitoneal drug delivery, which has the potential to improve the outcome for this dreaded condition. Edited by two renowned surgical oncologists, it represents the definitive reference in the field of intraperitoneal cancer therapy.

Authors
• Wim P. Ceelen, MD, PhD, professor of surgery, Ghent University Hospital, Belgium.
• Edward Levine, MD, professor of surgery and chief of surgical oncology, Wake Forest University, Winston-Salem, USA.