INTRODUCTION TO CANCER METASTASIS

• Part I. Cancer Metastasis From Primary Organs
o Chapter 1. Cancer Metastasis: An Introduction
? 1. Introduction
? 2. Disruption of Cell Adhesion: Initiation of Metastasis
? 3. Matrix Metalloproteinases in Cancer Metastasis
? 4. EMT in Cancer Metastasis
? 5. Organ-Specific Metastasis
? 6. microRNAs and Cancer Stem Cells in Cancer Metastasis
? 7. Conclusions and Perspectives
o Chapter 2. Breast Cancer Metastasis
? 1. Introduction
? 2. Biology
? 3. Metastatic Dissemination
? 4. Prognostic Factors After Recurrence
? 5. Treatment for Metastatic Breast Cancer
? 6. Conclusions
o Chapter 3. Prostate Cancer Metastasis
? 1. Epidemiology and Overview of Metastatic Prostate Cancer
? 2. Cellular Biology of Prostate Cancer Metastases
? 3. The Metastatic Cascade
? 4. Conclusions
o Chapter 4. Lung Cancer Metastasis
? 1. General Information
? 2. Mechanism of Metastasis
? 3. Molecular Mechanism in the Regulation of Lung Cancer Metastasis
? 4. Epithelial to Mesenchymal Transition in Lung Cancer
? 5. Cancer Stem Cells
? 6. Concluding Remarks
o Chapter 5. Cervical Cancer Metastasis
? 1. Introduction
? 2. Risk Factors
? 3. Pathogenesis
? 4. Histopathology
? 5. Routes of Dissemination
? 6. Major Molecular Factors
? 7. Conclusion
o Chapter 6. Colorectal Cancer Metastasis
? 1. Introduction
? 2. Molecular Aspects of Colorectal Cancer Metastasis
? 3. Main Sites of Colorectal Cancer Metastasis
? 4. Therapeutic Options for Metastatic Colorectal Cancer
? 5. Challenges and Probable Solutions
? 6. Conclusions
o Chapter 7. Metastatic Pancreatic Cancer: Current State and Future Directions
? 1. Introduction
? 2. Management of Pancreatic Ductal Adenocarcinoma
? 3. Molecular Mechanisms Driving Metastasis
? 4. In Vivo Experimental Models
? 5. Open Question: Onset and Dynamics of Metastases
? 6. Conclusions
o Chapter 8. Gastric Cancer Metastasis
? 1. Epidemiology and Screening Programs
? 2. Metastatic GC—Clinical Aspects
? 3. Diagnosis of Metastatic GC With a Particular Focus on 18-F-FDG PET/CT
? 4. Prognostic and Predictive Factors
? 5. Biomarkers
? 6. Treatment Methods of Metastatic GC
? 7. Conclusion
o Chapter 9. Hepatocellular Carcinoma: Metastatic Disease
? 1. Introduction
? 2. Epidemiology
? 3. Diagnosis
? 4. Prognosis and Staging
? 5. Treatment
? 6. Conclusions
o Chapter 10. Metastatic Bladder Cancer
? 1. Introduction
? 2. Epidemiology
? 3. Staging
? 4. Grading
? 5. Staging Tools
? 6. Emerging Biomarkers
? 7. Prognostic Factors
? 8. Clinical Presentation of Metastatic Bladder Disease
? 9. Management of Clinically Localized Bladder Cancer, Positive Pelvic Nodes and Metastatic Disease
? 10. Clinical Prognosticators
? 11. Management of Metastatic Bladder Cancer
? 12. New Agents
? 13. Immunotherapy
? 14. Role of Surgery in Metastatic Bladder Cancer
? 15. Conclusions
o Chapter 11. Metastatic Cutaneous Squamous Cell Carcinomas
? 1. Introduction
? 2. Defining the High-Risk Variant
? 3. Staging Systems
? 4. Treating High-Risk Cutaneous Squamous Cell Carcinoma
? 5. Sentinel Node Biopsy
? 6. Treatment of Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma
? 7. Concluding Remarks
o Chapter 12. Osteosarcoma Metastasis—Prognostic Factors and Treatment Strategies
? 1. Introduction
? 2. Clinical Features of Metastasis From Osteosarcoma
? 3. Treatment for Metastasis From Osteosarcoma
? 4. Conclusion
• Part II. Cancer Metastasis To Distant Organs
o Chapter 13. Lymph Node Metastasis
? 1. Introduction
? 2. History
? 3. Mechanisms—How Tumors Metastasize to Lymph Nodes
? 4. Clinical Aspects of Lymph Node Metastasis
? 5. Pathology
? 6. Conclusions & Summary
o Chapter 14. Molecular Involvement of the Bone Marrow Microenvironment in Bone Metastasis
? 1. Introduction
? 2. Types of Bone Metastasis
? 3. Pathophysiology of Bone Metastasis
? 4. Treatment Options for Bone Metastasis
? 5. Discussion/Conclusion
o Chapter 15. An Overview on Hepatic Metastasis
? 1. Introduction
? 2. Hepatic Physiology and Cancer Biology
? 3. Hepatic Functional and Surgical Anatomy
? 4. Clinical Presentation and Diagnosis
? 5. Treatment of Hepatic Metastases
? 6. Conclusions
o Chapter 16. Pulmonary Metastasis
? 1. Development of Pulmonary Metastases
? 2. Rationale for Local Treatment of Pulmonary Metastases
? 3. Diagnosis of Pulmonary Metastases
? 4. Preoperative Exams
? 5. Surgical Resection
? 6. Radiological Ablation
? 7. Radiotherapy
? 8. Lymph Node Involvement
? 9. Resection of Recurrent Metastases
? 10. Lung Metastasis in Given Tumor Types
? 11. Conclusion
o Chapter 17. Brain Metastasis: Basic Biology, Clinical Management, and Insight From Experimental Model Systems
? 1. Introduction
? 2. Biology
? 3. Clinical Management
? 4. Experimental Model Systems
? 5. Preclinical Findings
? 6. Conclusion
• Part III. Emerging Targets for Cancer Metastasis
o Chapter 18. Developmental Pathways: Emerging Therapeutic Targets for Cancer Metastasis
? 1. Introduction
? 2. Prometastatic Changes and Developmental Pathways
? 3. Notch Signaling and Metastasis
? 4. Antimetastatic Potential of Wnt and Hedgehog Targeting
? 5. Concluding Remarks
o Chapter 19. Emerging Therapeutic Targets for Cancer Metastasis: From the Perspective of Embryo Implantation
? 1. Introduction
? 2. The Similarity Between Embryo Implantation and Tumor Metastasis
? 3. Trophoblast Invasion Inhibitory Factors Derived From the Maternal Endometrium During Embryo Implantation and Their Implications in Cancer Metastasis
? 4. Conclusions and Perspectives
o Chapter 20. Wnt Signaling as a Therapeutic Target in Cancer and Metastasis
? 1. Introduction
? 2. Wnt Signaling and Cancer
? 3. The Role of Wnt Signaling in Epithelial–Mesenchymal Transition and Cancer Stem Cells
? 4. Therapeutic Strategies Targeting Wnt Signaling
? 5. Protein Knockdown Strategies
? 6. Viral-Based Therapies
? 7. Conclusion

Features:
• Includes basic biology and translational approaches to organ-specific cancer sites
• Provides readers with information on emerging therapeutic targets for cancer metastasis
• Contains contributions from leading researchers around the globe

Author
Aamir Ahmad, Mitchell Cancer Institute, University of South Alabama, Mobile, AL USA