INVASIVE STUDIES OF THE HUMAN EPILEPTIC BRAIN. PRINCIPLES AND PRACTICE

• Section 1: General overview
1: History of invasive EEG,
2: Principles of invasive EEG,
3: Technical and practical aspects of invasive recordings and brain stimulation,
4: Subdural grid electrode placement: Approaches and complications,
5: Depth electrodes: Approaches and complications,
• Section 2: Identifying and mapping epileptiform and non-epileptiform activity
6: Physiological activity and artifacts in the human epileptic brain studied with intracerebral depth electrodes EEG,
7: Physiological activity and artefacts in epileptic brain in subdural EEG,
8: The irritative zone and seizure onset zone in subdural EEG,
9: The irritative, epileptogenic and ictal onset zones in depth EEG,
10: The irritative zone and seizure onset zone in acute ECoG: The quest for relevant epileptogenic tissue,
11: High frequency oscillations (HFO),
12: Direct current shift recordings,
13: Electrical stimulation for the mapping of the epileptogenic zone,
14: Invasive EEG and hippocampal sclerosis,
15: Invasive EEG in cortical dysplasia,
16: Invasive EEG in tumoral epilepsy,
17: Invasive EEG in tuberous sclerosis,
18: Invasive EEG in gray matter heterotopia,
19: SEEG in polymicrogyria: When and how?,
20: Invasive EEG in hypothalamic hamartoma,
• Section 3: Invasive EEG approaches in specific clinical situations
21: SEEG in temporal lobe epilepsy,
22: Subdural EEG in temporal lobe epilepsy,
23: SEEG in frontal lobe epilepsy,
24: Subdural EEG in frontal lobe epilepsy,
25: SEEG in the posterior cortex epilepsies,
26: Subdural EEG in posterior cortex epilepsy,
27: Invasive EEG investigation of the insula,
28: Depth EEG in sensorimotor cortex epilepsy,
29: Invasive studies of sensory motor cortex epilepsy,
• Section 4: Human brain mapping
30: Human brain mapping using subdural electrodes,
31: Intracranial event-related potentials,
32: Cortico-cortical evoked potential mapping,
33: Dynamic spectral imaging: Online and offline functional brain mapping using high-frequency activity [50 Hz – 150 Hz] in SEEG,
• Section 5: Therapy using invasive EEG
34: Thermocoagulation of the ictal onset zone using SEEG (thermo-SEEG),
35: Therapeutic stimulation of the ictal onset zone,
• Section 6: Special techniques and future prospects
36: Simultaneous macro- and micro-recordings,
37: Fast analytical sensing technology: Microelectrode-based recordings of tonic and phasic neurotransmitter signaling in the mamalian brain,
38: Mapping of seizure networks,
39: SEEG recordings: From signal processing to models of epileptogenic networks,

No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing.

Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations.

The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Features
• Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the use of invasive electroencephalography in a variety of clinical situations.
• The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Authors
• Samden D. Lhatoo, Professor of Neurology, Department of Neurology, UH Case Medical Center, Cleveland, OH, USA. Professor of Neurology, and Dorothy Blair and Robert Daroff Chair in Neurology, in the Department of Neurology, UH Case Medical Center, Cleveland, OH, USA.
• Philippe Kahane, Director, Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France. Director of the Unit for Epilepsy and Neurological Diseases at the Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France.
• Hans O. Lüders, Professor of Neurology, Department of Neurology, UH Case Medical Center, Cleveland, OH, USA. Professor of Neurology in the Department of Neurology, UH Case Medical Center, Cleveland, OH, USA.