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63,65 €Preface
1. Introduction
2. Ions on the move
3. Investigating channel activity
4. Molecular structures
5. Permeability and selectivity
6. Gating and modulation
7. Drugs and toxins
8. Dysfunctional channels in human disease
9. Not the last word
References
Index.
Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.
Features
• Up-to-date introduction aimed at students. It does not assume much initial knowledge but takes the reader to the frontiers of understanding
• Has a molecular emphasis, based on recent advances in gene therapy and electrophysiology
• Covers the diseases caused when channels don't work properly (such as cystic fibrosis)
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