IRWIN AND RIPPE'S INTENSIVE CARE MEDICINE (2 VOLUME SET). 9TH EDITION

Section Editors vi
Contributing Authors viii
Preface xxxi
Acknowledgments xxxii

Vol I
• Section 1 PROCEDURES, TECHNIQUES AND ULTRASONOGRAPHY
Chapt er 1 Point- of- Care Critical Care Ultrasonography 1
Chapt er 2 Anesthesia for Bedside Procedures 4
Chapt er 3 Management of Pain in the Critically Ill 11
Chapt er 4 Therapeutic Paralysis 22
Chapt er 5 Cerebrospinal Fluid Aspiration 29
Chapt er 6 Central Venous Catheters 38
Chapt er 7 Arterial Line Placement and Care 54
Chapt er 8 Airway Management and Endotracheal Intubation 64
Chapt er 9 Tracheostomy 82
Chapt er 10 Bronchoscopy 91
Chapt er 11 Lung Ultrasonography 97
Chapt er 12 Thoracentesis 102
Chapt er 13 Chest Tube Insertion and Care 111
Chapter 14 Cardiopulmonary Resuscitation 119
Chapter 15 Cardioversion and Defibrillation 135
Chapter 16 Critical Care Echocardiography 140
Chapter 17 Pericardiocentesis 146
Chapter 18 Temporary Cardiac Pacing 155
Chapter 19 Pulmonary Artery Catheters 161
Chapter 20 Gastrointestinal Endoscopy 176
Chapter 21 Endoscopic Placement of Feeding Tubes 183
Chapter 22 Gastroesophageal Balloon Tamponade for Acute Variceal Hemorrhage 190
Chapter 23 Paracentesis and Diagnostic Peritoneal Lavage 195
Chapter 24 Interventional Radiology: Percutaneous Drainage Techniques 204
Chapter 25 Percutaneous Suprapubic Cystostomy 212
Chapter 26 Aspiration of the Knee and Synovial Fluid Analysis 216
• Section 2 MINIMALLY INVASIVE MONITORING
Chapter 27 Routine Monitoring of Critically Ill Patients 222
Chapter 28 Minimally Invasive Hemodynamic Monitoring 236
Chapter 29 Respiratory Monitoring During Mechanical Ventilation 248
Chapter 30 Neurologic Multimodal Monitoring 261
Chapter 31 Role of Tele- Critical Care in the Health Care System 279
• Section 3 PALLIATIVE CARE AND ETHICAL ISSUES IN THE INTENSIVE CARE UNIT
Chapter 32 Palliative Care in the ICU 288
Chapter 34 Managing Symptoms in Critically Ill Patients 308
Chapter 35 Being With Suffering: Addressing Existential and Spiritual Distress 321
• Section 4 SHOCK, TRAUMA AND SEPSIS MANAGEMENT
Chapter 36 Resuscitation From Shock Following Hemorrhage 328
Chapter 37 Trauma Systems 341
Chapter 38 Management of Sepsis 347
Chapter 39 Multiple Organ Dysfunction Syndrome 358
Chapter 40 Traumatic Brain Injury 363
Chapter 41 Spinal Cord Trauma 371
Chapter 42 Thoracic and Cardiac Trauma 381
Chapter 43 Critical Care of the Patient With Abdominal Trauma 394
Chapter 44 Orthopedic Injury 402
Chapter 45 Burn Management 417
• Section 5 SURGICAL PROBLEMS IN THE INTENSIVE CARE UNIT
Chapter 46 Surgeon and Intensivist Collaboration in the Care of the ICU Patient 423
Chapter 47 Surgical Infections in the Intensive Care Unit 427
Chapter 48 Care of the Patient with Necrotizing Fasciitis 430
Chapter 49 The ICU Management of Patients Undergoing Major Surgery for Gastrointestinal Cancers 435
Chapter 50 The ICU Approach to the Acute Abdomen 440
Chapter 51 Abdominal Compartment Syndrome 444
Chapter 52 Management of the Obstetrical Patient in the Intensive Care Setting 448
Chapter 53 Acute Limb Ischemia in the ICU Population 454
Chapter 54 Palliative Surgery in the Intensive Care Unit 459
• Section 6 TRANSPLANTATION
Chapter 55 Management of the Organ Donor 467
Chapter 56 Critical Care Problems in Kidney Recipients 491
Chapter 57 Critical Care of Liver Transplant Recipients and
Chapter 58 Critical Care of the Lung Transplant Recipient 515
Chapter 59 Critical Care Problems in Heart and Heart- Lung Transplant Recipients 530
Chapter 60 Care of the Pancreas Transplant Recipient 538
Chapter 61 Critical Care of Intestinal Transplant Recipients 553
Chapter 62 Immunosuppression in Solid- Organ Transplantation 562
Chapter 63 Hematopoietic Cell Transplantation 569
Chapter 64 Management of Graft- vs- Host Disease, Infection, Malignancy, and Rejection in Transplant Recipients 586
• Section 7 RHEUMATOLOGIC, IMMUNOLOGIC, AND DERMATOLOGIC DISEASES IN THE INTENSIVE CARE UNIT
Chapter 65 Rheumatologic Diseases in the Intensive Care Unit 606
Chapter 66 Vasculitis in the Intensive Care Unit 631
Diseases 639
Chapter 68 Anaphylaxis 648
Chapter 69 Dermatology in the Intensive Care Unit 661
• Section 8 INFECTIOUS DISEASE PROBLEMS IN THE INTENSIVE CARE UNIT
Chapter 70 Approach to Fever for the ICU Patient 683
Chapter 71 Prevention and Control of Health Care–Acquired Infections in the Intensive Care Unit 690
Chapter 72 Use of Antimicrobials in the Treatment of Infection in the Critically Ill Patient 697
Chapter 73 Lif e- Thr eat ening Comm unity- Acquir ed Bact er ial and Parasitic Infections 713
Chapter 74 Acute Infection in the Non–HIV- Infected Immunocompromised Host 722
Chapter 75 Intensive Care of Patients With HIV Infection 732
Chapter 76 Infectious Complications of Persons Who Inject Drugs 740
Chapter 77 Infective Endocarditis and Infections of Intracardiac Prosthetic Devices 746
Chapter 78 Infections Associated With Vascular Catheters 768
Chapter 79 Urinary Tract Infections 775
Chapter 80 Central Nervous System Infections 785
Chapter 81 Tuberculosis 796
Chapter 82 Serious Epidemic Viral Pneumonias 804
Chapter 83 COVID- 19: Presentation, Treatment, and Course of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the Intensive Care Unit 815
Chapter 84 Critical Care of Patients Infected With Ebola Virus 822
Chapter 85 Botulism 826
Chapter 86 Tetanus 829
• Section 9 HEMATOLOGIC AND ONCOLOGIC PROBLEMS IN THE INTENSIVE CARE UNIT
Jonathan Gerber
Chapter 87 Disorders of Hemostasis in Critically Ill Patients 832
Chapter 88 Transfusion Therapy: Blood Components and Transfusion Complications 848
Chapter 89 Anemia in the Critical Care Setting 856
Chapter 90 Thrombocytopenia 871
Chapter 91 Venous Thromboembolism and Associated Prothrombotic Disorders in the Intensive Care Unit 882
Chapter 92 Antithrombotic Pharmacotherapy 906
Chapter 93 Critical Care of Patients with Hematologic Malignancies 928
Chapter 94 Oncologic Emergencies 940
Chapter 95 Therapeutic Apheresis: Technical Considerations and Indications in Critical Care 952
• Section 10 PHARMACOLOGY, OVERDOSES AND POISONINGS
Chapter 96 General Considerations in the Evaluation and Treatment of Poisoning 964
Chapter 97 Acetaminophen Poisoning 981
Chapter 98 Alcohols and Glycol Poisoning 989
Chapter 99 Amphetamines 1004
Chapter 100 Antiarrhythmic Agents 1011
Chapter 101 Anticholinergic Poisoning 1021
Chapter 102 Anticonvulsant Poisoning 1024
Chapter 103 Antidepressant Poisoning 1033
Chapter 104 Antipsychotic Poisoning 1045
Chapter 105 ß- Bloc k er P oisoning 1056
Chapter 106 Calcium Channel Blocker Poisoning 1060
Chapter 107 Cardiac Glycoside Poisoning 1067
Chapter 108 Cholinergic Poisoning 1071
Chapter 109 Cocaine Poisoning 1077
Chapter 110 Corrosives Poisoning 1083
Chapter 111 Heavy Metal Poisoning 1088
Chapter 112 Hydrocarbon Poisoning 1102
Chapter 113 Hydrofluoric Acid Poisoning 1108
Chapter 114 Iron Poisoning 1110
Chapter 115 Isoniazid Poisoning 1115
Chapter 116 Lithium Poisoning 1119
Chapter 117 Methylxanthine Poisoning 1124
Chapter 118 Opioid Poisoning 1131
Chapter 119 P esticide- Herbicide P oisoning 1140
Chapter 120 Phencyclidine and Hallucinogen Poisoning 1154
Chapter 121 Salicylate and Other Nonsteroidal Anti- inflammatory Drug Poisoning 1161
Chapter 122 Sedativ e- Hypnotic Agent P oisoning 1169
Chapter 123 Terrestrial Envenomations 1177
Chapter 124 Therapeutic Agents for Overdoses and Poisonings 1190
Chapter 125 Withdrawal Syndromes 1210
• Section 11 CRITICAL CARE CONSEQUENCES OF WEAPONS (AGENTS) OF MASS DESTRUCTION
Chapter 126 Planning and Organization for Emergency Mass Critical Care 1222
Chapter 127 Chemical Agents of Mass Destruction 1229
Chapter 128 The Management of Acute Radiation Casualties 1239
Chapter 129 Critical Care Consequences of Weapons (or Agents) of Mass Destruction—Biological Agents of Mass Destruction 1249
• Section 12 ICU DESIGN, ORGANIZATION, OPERATION AND OUTCOME MEASURES
Chapter 130 Intensive Care Unit Design: Current Standards and Future Trends 1273
Chapter 131 Intensive Care Unit Organization and Management 1285
Chapter 132 Critical Care Information Systems (Systems of Engagement and Insight): Structure, Function, and Future 1295
Chapter 133 Defining and Measuring Patient Safety in the Critical Care Unit 1305
Chapter 134 Assessing the Impact of Critical Care: Outcomes Research and Methodologies in the Current Era 1314
Chapter 135 Blockchain Technology and Medical Device Security in the Intensive Care Unit 1325
• Section 13 ENDOCRINE PROBLEMS IN THE INTENSIVE CARE UNIT
Chapter 136 Management of Hyperglycemia in Critically Ill Patients 1330
Chapter 137 Diabetic Comas: Ketoacidosis and Hyperosmolar Hyperglycemic State 1338
Chapter 138 Hypoglycemia 1350

VOLUME 2
• Chapter 139 Hypoadrenal Crisis and the Stress Management of the Patient on Chronic Steroid Therapy 1365
Chapter 140 Disorders of Mineral Metabolism 1368
Chapter 141 Severe Hyperthyroidism 1375
Chapter 142 Myxedema Coma 1378
Chapter 143 Nonthyroidal Illness Syndrome (Sick Euthyroid Syndrome) in the Intensive Care Unit 1382
• Section 14 NEUROLOGIC PROBLEMS IN THE INTENSIVE CARE UNIT
Chapter 144 An Approach to Neurologic Problems in the Intensive Care Unit 1397
Chapter 145 Evaluating the Patient With Altered Consciousness in the Intensive Care Unit 1400
Chapter 146 Metabolic Encephalopathy 1416
Chapter 147 Mental Status Dysfunction in the Intensive Care Unit: Postoperative Cognitive Impairment 1424
Chapter 148 Generalized Anoxia/Ischemia of the Nervous System 1429
Chapter 149 Cerebrovascular Diseases 1432
Chapter 150 Subarachnoid Hemorrhage 1443
Chapter 151 Status Epilepticus 1449
Chapter 152 Guillain- Barr é Syndr ome 1457
Chapter 153 Myasthenia Gravis in the Intensive Care Unit 1467
Chapter 154 Newly Acquired Weakness in the Intensive Care Unit: Critical Illness Myopathy and Neuropathy 1475
Chapter 155 Neuro- oncological Problems in the Intensive Care Unit 1479
Chapter 156 Miscellaneous Neurological Problems in the Intensive Care Unit 1491
• Section 15 PSYCHIATRIC ISSUES IN THE INTENSIVE CARE UNIT
Chapter 157 Diagnosis and Treatment of Agitation and Delirium in the Intensive Care Unit Patient 1499
Chapter 158 Diagnosis and Treatment of Anxiety in the Intensive Care Unit Patient 1508
Chapter 159 Diagnosis and Treatment of Depression in the Intensive Care Unit Patient 1516
Chapter 160 Managing the Suicidal Patient in the Intensive Care Unit 1534
Chapter 161 Problematic Behaviors of Patients, Family, and Staff in the Intensive Care Unit 1537
Chapter 162 Recognition and Management of Staff Stress in the Intensive Care Unit 1543
• Section 16 PULMONARY PROBLEMS IN THE INTENSIVE CARE UNIT
Chapter 163 Acute Respiratory Failure Due to Acute Respiratory Distress Syndrome and Pulmonary Edema 1548
Chapter 164 Acute Respiratory Failure in Pregnancy 1566
Chapter 165 Extrapulmonary Causes of Respiratory Failure 1582
Chapter 166 Invasive Mechanical Ventilation and Extracorporeal Life support for Respiratory Failure 1593
Chapter 167 Mechanical Ventilation—Part II: Noninvasive Mechanical Ventilation for the Adult Hospitalized Patient 1611
Chapter 168 Discontinuation of Mechanical Ventilation 1629
Chapter 169 Respiratory Adjunctive Therapies 1639
Chapter 170 Aspiration 1654
Chapter 171 Drowning 1660
Chapter 172 Acute Exacerbation of Asthma 1666
Chapter 173 Critical Care of Acute Exacerbations of Chronic Obstructive Pulmonary Disease 1679
Chapter 174 Pulmonary Hypertension in the Intensive Care Unit 1687
Chapter 175 Managing Hemoptysis 1694
Chapter 176 Pleural Diseases of the Critically Ill Patient 1704
Chapter 177 Gas Embolism Syndromes 1720
Chapter 178 Acute Inhalational Injuries 1733
Chapter 179 Chest Radiographic Examination 1750
Chapter 180 Severe Upper Airway Infections 1772
Chapter 181 Acute Infectious Pneumonia 1786
Chapter 182 Interventional Pulmonary in the Intensive Care Unit 1814
Chapter 183 Sleep Issues in the Intensive Care Unit Setting 1828
Chapter 184 Disorders of Temperature Control, Part I: Hypothermia 1840
Chapter 185 Disorders of Temperature Control, Part II: Hyperthermia 1854
• Section 17 CARDIOVASCULAR PROBLEMS AND CORONARY CARE
Chapter 186 Evolution of the Modern Cardiovascular Intensive Care Unit 1867
Chapter 187 Unstable Angina/Non–ST- Segment Elevation Myocardial Infarction, the Non–ST- Elevation Acute Coronary Syndromes 1872
Chapter 188 ST- Segment Elevation Myocardial Infarction 1886
Chapter 189 Mechanical Complications of Myocardial Infarction 1904
Chapter 190 Management of Acute Decompensated Heart Failure 1911
Chapter 191 Pharmacological Management of Shock and Hypotension 1924
Chapter 192 Mechanical Circulatory Support for Cardiogenic Shock 1940
Chapter 193 Valvular Heart Disease 1958
Chapter 194 Acute Aortic Syndromes 1976
Chapter 195 Management of the Cardiac Arrest Survivor 1994
Chapter 196 Management of Common Arrhythmias in the Intensive Care Unit 2004
Chapter 197 Management of Cardiac Devices in the ICU 2021
• Section 18 RENAL PROBLEMS IN THE INTENSIVE CARE UNIT
Chapter 198 Metabolic Acidosis and Metabolic Alkalosis 2033
Chapter 199 Disorders of Plasma Sodium and Plasma Potassium 2044
Chapter 200 Acute Kidney Injury in the Intensive Care Unit 2069
Chapter 201 Renal Replacement Therapy for the Critically Ill 2092
Chapter 202 Ultrasonography for the Evaluation of the Urinary System 2106
Chapter 203 Drug Dosing in Renal and Hepatic Failure: A Pharmacokinetic Approach to the Critically Ill Patient 2109
• Section 19 GASTROINTESTINAL DISEASE PROBLEMS IN THE INTENSIVE CARE UNIT
Chapter 204 Gastrointestinal Bleeding 2130
Chapter 205 Stress Ulcer and Acid Peptic Disease 2138
Chapter 206 Nausea and Vomiting 2144
Chapter 207 Gastrointestinal Motility of the Critically Ill Patient 2153
Chapter 208 Hepatic Dysfunction and Liver Failure 2160
Chapter 209 Severe and Complicated Biliary Tract Disease 2171
Chapter 210 Acute Pancreatitis 2176
Chapter 211 Diarrhea and Constipation 2185
Chapter 212 Fulminant Colitis and Toxic Megacolon 2193
• Section 20 METABOLISM AND NUTRITION
Chapter 213 Nutritional Therapy in the Critically Ill Patient 2199
Chapter 214 Parenteral and Enteral Nutrition in the Intensive Care Unit 2204
Chapter 215 Disease- Specific Nutr ition 2219
Appendix CALCULATIONS COMMONLY USED IN CRITICAL CARE 2231
Index I-1

Covering both the theoretical and practical aspects of critical care,Irwin & Rippe’s Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties.
• Provides easy access to evidence-based critical care practice
• Offers a practical, clinically oriented approach to intensive care, with detailed descriptions of procedures, incorporating new ultrasound and how-to videos that can easily be accessed in the eBook
• Key points are identified at the beginning of each chapter and in the margins of the text
• Key references chosen by the author experts are highlighted at the end of each chapter
• Available even during network downtime
• A key educational tool for learning critical care
• Comprehensive coverage of topics in the field of critical care, including current information provided in 215 chapters authored by well-recognized experts
• In-depth, comprehensive coverage that allows key skill acquisition
• Useful resource for board preparation
• New multiple-choice questions with annotated answers accompany each chapter in the eBook
• Brings new expertise with senior editor Dr. Walter A. Boyle and online question editor William F. Kelly

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