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1. Joint Function and Dysfunction
2. Overview of Orthobiologics and Joint Function
3. Cost of Disability
4. Joint Homeostasis of the Knee: Role of Senescence, Hormones, Cells, and Biological Factors in Maintaining Joint Health
5. “Preparing the Soil”: Optimizing Metabolic Management in Regenerative Medicine Procedures
6. Bone Anatomy and Healing Process of a Fracture
7. The Osteochondral Unit
8. Diagnosis of Cartilage and Osteochondral Defect
9. Bone Marrow Edema
10. Functional Anatomy of Cartilage and Subchondral Bone in the Joint
11. Mapping of the Osteochondral Defect
12. Subchondral Bone and Healthy Cartilage
13. Failure or Delay of Fracture Healing
14. Avascular Necrosis
15. Current Concepts in Subchondral Bone Pathology
16. Osteochondral Pathologies as Effect of General Diseases
17. Understanding Genetics in Osteochondral Pathologies
18. Tissue Engineering: Scaffolds and Bio-Tissues
19. 3D Bioprinting of the Osteochondral Unit
20. Biphasic Osteochondral Restoration Techniques Using Synovial Stem Cells and Artificial Bone
21. Proximal Tibial Subchondral Cystic Lesion Treatment with Osteo-Core-Plasty
22. Inflammatory Environment and Cartilage Repair
23. Management of Articular Cartilage Lesions of the Glenohumeral Joint
24. Nontraumatic Shoulder Osteochondral Defects
25. OCD of the Elbow: Treatment by Autograft
26. Elbow Osteochondral Unit Function
27. Wrist Osteochondral Unit Function and Treatment
28. Hip Osteochondral Unit Function and Treatment
29. Nontraumatic Hip Osteochondral Pathologies
30. Knee Osteochondral Lesions Treatments
31. Ankle Osteochondral Pathologies and Treatment
32. At-AMIC: A Reliable Solution for Talar Osteochondral Lesions
33. Osteochondral Lesions of the Ankle: Talus and Distal Tibia
34. Conservative Treatments of Osteochondral Lesions of the Knee
35. Principles of Rehabilitation in Cartilage and Lesions

This user-friendly, pragmatic book discusses the normal and pathological conditions of the appendicular skeleton, with a focus on the preservation of joint function, providing a detailed overview of strategies for both common and complex joint preservation.
The first section covers basic topics, ranging from joints homeostasis and biomechanics, to genetics, bio-orthopedics, tissue engineering and 3D bioprinting. The following sections are each dedicated to a specific joint – its functional anatomy, pathologic conditions, diagnostics and treatment.
This book is of interest to orthopedists and sports medicine specialists treating common and complex injuries of the joints.

• Reviews the anatomy, biomechanics and function of joints
• Provides an in-depth overview of strategies for both common and complex joint preservation
• Discusses the effects of joint malalignment and joint failure

• Alberto Gobbi completed his residency in orthopedic surgery at the Medical Faculty of Milan University in 1988, and in Sports Medicine in Genoa, in 1992. He was one of the first Europeans to join the International Cartilage Repair Society and he worked for several years with the leading international experts in orthopedic surgery, arthroscopy and regenerative medicine. He founded OASI Bioresearch Foundation Gobbi Onlus (NPO), which is recognized as an international teaching center by ISAKOS and ICRS, and has dedicated his time to the education of hundreds of fellows over the last 20 years. He is the Immediate Past President of ICRS and Member of Board of Directors of Isakos. He worked as Visiting Professor at UCSD San Diego and was appointed as Honorary Professor at University of Beijing, Singapore and Seoul.
• John G. Lane is a Clinical Associate Professor-voluntary at the Department of Orthopedic Surgery, at the University of California, San Diego. Dr. Lane completed his residency at the University of Michigan and fellowship training in sports medicine at UCSD. He is a member of AAOS, AANA, AOSSM, ISAKOS and ICRS. Currently he is the chair of the ICRS membership committee and chairman of the ISAKOS education committee. His clinical field of practice focuses on complex knee and shoulder injuries and he is pursuing ongoing research into rotator cuff injury, the effect of diabetes and regeneration of articular cartilage.
• Umile Giuseppe Longo is an Associate Professor and Consultant in Trauma and Orthopedic Surgery at the University Campus Bio-Medico of Rome. He is member of the editorial board of high-impact journals in the field of sports medicine and orthopedics, and editor of the Orthopedics and Biomechanics section of BMC Musculoskeletal Disorders. He is author of more than 300 peer-reviewed papers and co-author of more than 80 chapters published in international books. He has been the recipient of several prestigious national and international awards. His research interests include shoulder traumatology and replacement.
• Dr. Ignacio Dallo is an Orthopaedic Surgeon Recertified as Qualified by the University of Buenos Aires and the Argentine Association of Orthopaedics and Traumatology. He published peer-reviewed articles, book chapters, and book translations. His work areas are Bio-Orthopaedics, Knee Arthroscopy, and Sports injuries. Dr. Ignacio Dallo collaborated with the International Olympic Committee Research Team at the Youth Olympic Games in Buenos Aires in 2018. He is a current member of the Education and Sports Medicine Committees for ISAKOS, NextGen Committee for ICRS, and International Committee for AANA. Associate Editor of the Journal of Cartilage and Joint Preservation. Reviewer of the Journal of ISAKOS.