LEFT ATRIAL APPENDAGE CLOSURE. MECHANICAL APPROACHES TO STROKE PREVENTION IN ATRIAL FIBRILLATION. CONTEMPORARY CARDIOLOGY

Table of contents (20 chapters)
1.Atrial Fibrillation and Stroke Epidemiology
2.Efficacy and Limitations of Warfarin and Novel Oral Anticoagulants with Atrial Fibrillation
3.Mechanistic Rationale for LAA Closure with AF and Stroke Prevention
4.LAA Anatomy
5.Conventional Surgery for LAA Closure
6.The Use of Transesophageal Echocardiography to Guide Percutaneous LAA Closure
7.The Use of Intracardiac Echocardiography (ICE) to Guide LAA Closure
8.CT Imaging for Percutaneous LAA Closure
9.PLAATO Device
10.WATCHMAN Device
11.WATCHMAN: Trials and Registries Results
12.Amplatzer Cardiac Plug and Amulet
13.ACP and Amulet: Trials and Registries Results
14.LARIAT: The Endo-Epicardial Technique for Left Atrial Appendage Exclusion
15.LARIAT: Trials and Registries Results
16.Novel Percutaneous LAA Closure Devices in Clinical or Preclinical Trials
17.Concomitant Left Atrial Appendage Closure and Catheter Ablation of Atrial Fibrillation
18.Procedural Complications and Management
19.Antiplatelet and Anticoagulant Strategies Following Left Atrial Appendage Closure
20.Device-Related Thrombi, Residual Leaks, and Consequences

- Unique and timely examination of left atrial appendage closure technique and devices
- Explores the use of left atrial appendage closure in the reduction of thromboembolism in patients with atrial fibrillation
- Discusses current percutaneous approaches and devices available for left atrial appendage closure

This book provides a comprehensive overview of state-of-the-art left atrial appendage (LAA) closure, covering epidemiology of atrial fibrillation and stroke, LAA anatomy, surgical approaches, imaging for LAA closure, LAA closure procedure, and post-procedural management. LAA closure is a rapidly emerging field in stroke prevention for patients with atrial fibrillation. Several percutaneous and surgical devices are now available in many countries, including WATCHMAN, Amplatzer Cardiac Plug and Amulet, and LARIAT devices, and many more are in clinical development and are being evaluated in research trials. As LAA closure is a technically challenging procedure, detailed knowledge of the rationale, anatomy, and technical approach of this modality guides clinicians in patient selection and facilitates procedural success. Left Atrial Appendage Closure is a valuable resource for interventional cardiologists, electrophysiologists, echocardiographers, radiographers, fellows, and residents in guiding the management of patients prior to, during, and following LAA closure.

Authors
- Jacqueline Saw, MD, FRCPC, FACC, FSCAI Clinical Associate Professor University of British Columbia Head, VGH Cardiology Clinical Trials Research Program Director, VGH Interventional Cardiology Fellowship Vancouver General Hospital 2775 Laurel Street, Level 9 Vancouver, V5Z1M9, British Columbia Canada
- Saibal Kar, MD, FACC Director, Interventional Cardiology Research Cedars-Sinai Medical Center 8631 W. 3rd Street, #415E Los Angeles, CA 90048
- Matthew J. Price, MD, FACC, FSCAI Director, Cardiac Catheterization Laboratory Division of Cardiovascular Diseases Scripps Clinic Assistant Professor Scripps Translational Science Institute 10666 North Torrey Pines Road, Maildrop S1056 La Jolla, CA 92037 Jacqueline Saw is the editor of Carotid Artery Stenting: The Basics (978-1-60327-313-8, 2009) and Handbook of Complex Percutaneous Carotid Intervention (978-1-58829-605-4, 2007), both of which are volumes in the Contemporary Cardiology series.