• UNIT I: INTRODUCTION
1. Prescriptive Authority
2. Rational Drug Selection and Prescription Writing
3. Promoting Positive Outcomes of Drug Therapy
• UNIT II: BASIC PRINCIPLES OF PHARMACOLOGY
4. Pharmacokinetics, Pharmacodynamics, and Drug Interactions
5. Adverse Drug Reactions and Medication Errors
6. Individual Variation in Drug Responses
7. Genetic and Genomic Considerations in Pharmacotherapeutics NEW!
• UNIT III: DRUG THERAPY ACROSS THE LIFE SPAN
8. Drug Therapy During Pregnancy and Breast-Feeding
9. Drug Therapy in Pediatric Patients
10. Drug Therapy in Geriatric Patients
• UNIT IV: PERIPHERAL NERVOUS SYSTEM DRUGS
11. Basic Principles of Neuropharmacology
12. Physiology of the Peripheral Nervous System
13. Muscarinic Agonists
14. Muscarinic Antagonists NEW!
15. Adrenergic Agonists
16. Adrenergic Antagonists
17. Indirect-Acting Antiadrenergic Agents
• UNIT V: CENTRAL NERVOUS SYSTEM DRUGS
18. Introduction to Central Nervous System Pharmacology
19. Drugs for Parkinson Disease
20. Drugs for Alzheimer Disease
21. Drugs for Seizure Disorders
22. Drugs for Muscle Spasm and Spasticity
• UNIT VI: DRUGS FOR PAIN
23. Local Anesthetics
24. Opioid Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics
25. Drugs for Headache
• UNIT VII: PSYCHOTHERAPEUTIC DRUGS
26. Antipsychotic Agents and Their Use in Schizophrenia
28. Drugs for Bipolar Disorder
29. Sedative-Hypnotic Drugs
30. Management of Anxiety Disorders
31. Central Nervous System Stimulants and Attention-Deficit/Hyperactivity Disorder
• UNIT VIII: SUBSTANCE USE DISORDERS
32. Substance Use Disorders I: Basic Considerations
33. Substance Use Disorders II: Alcohol
34. Substance Use Disorders III: Nicotine and Smoking
35. Substance Use Disorders IV: Major Drugs of Abuse Other Than Alcohol and Nicotine
• UNIT IX: DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, BLOOD, AND BLOOD VOLUME36. Review of Hemodynamics
38. Drugs Acting on the Renin-Angiotensin-Aldosterone System
39. Calcium Channel Blockers
41. Drugs for Hypertension
42. Drugs for Heart Failure
43. Antidysrhythmic Drugs
44. Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol and Triglyceride Levels
45. Drugs for Angina Pectoris
46. Anticoagulant, Antiplatelet, and Thrombolytic Drugs
47. Drugs for Deficiency Anemias
• UNIT X: DRUGS FOR ENDOCRINE DISORDERS
48. Drugs for Diabetes Mellitus
49. Drugs for Thyroid Disorders
• UNIT XI: WOMEN'S HEALTH
50. Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications
51. Birth Control
• UNIT XII: MEN'S HEALTH
53. Drugs for Erectile Dysfunction and Benign Prostatic Hyperplasia
• UNIT XIII: ANTI-INFLAMMATORY, ANTIALLERGIC, AND IMMUNOLOGIC DRUGS
54. Review of the Immune System
55. Childhood Immunization
57. Cyclooxygenase Inhibitors: Nonsteroidal Anti-inflammatory Drugs and Acetaminophen
58. Glucocorticoids in Nonendocrine Disorders
• UNIT XIV: DRUGS FOR BONE AND JOINT DISORDERS
59. Drug Therapy of Rheumatoid Arthritis
60. Drug Therapy of Gout
61. Drugs Affecting Calcium Levels and Bone Mineralization
• UNIT XV: RESPIRATORY TRACT DRUGS
62. Drugs for Asthma and Chronic Obstructive Pulmonary Disease
63. Drugs for Allergic Rhinitis, Cough, and Colds
• UNIT XVI: GASTROINTESTINAL DRUGS
64. Drugs for Peptic Ulcer Disease
66. Other Gastrointestinal Drugs
• UNIT XVII: NUTRITION AND COMPLIMENTARY THERAPIES
68. Drugs for Weight Loss
69. Complementary and Alternative Therapies
• UNIT XIII: THERAPY OF INFECTIOUS AND PARASITIC DISEASES
70. Basic Principles of Antimicrobial Therapy
71. Drugs That Weaken the Bacterial Cell Wall I: Penicillins
72. Drugs That Weaken the Bacterial Cell Wall II: Other Drugs
73. Bacteriostatic Inhibitors of Protein Synthesis
74. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis
75. Sulfonamides and Trimethoprim
76. Drug Therapy of Urinary Tract Infections
77. Drugs Therapy for Tuberculosis
78. Miscellaneous Antibacterial Drugs
79. Antifungal Agents
80. Antiviral Agents I: Drugs for Non-HIV Viral Infections
81. Antiviral Agents II: Drugs for HIV Infection and Related Opportunistic Infections
82. Drug Therapy of Sexually Transmitted Diseases
83. Anthelmintics, Antiprotozoal Drugs, and Ectoparasiticides
• UNIT XIX: CANCER THERAPY
84. Introduction to Immunomodulators NEW!
85. Supportive Care of Patients Receiving Anticancer Drugs
86. Drugs for Cancer Pain
• UNIT XX: Drugs for Eyes, Ears, and Skin
87. Drugs for the Eye
88. Drugs for the Skin
89. Drugs for the Ear
• UNIT XXI: DRUG THERAPY IN ACUTE CARE
90. Agents Affecting the Volume and Ion Content of Body Fluids
91. Management of ST-Elevation Myocardial Infarction
92. Additional Acute Care Drugs
APPENDIX: Canadian Drug Information
Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants, 2nd Edition builds on the same foundation of clearly explained, up-to-date, and clinically current content as the trusted Lehne undergraduate text, while focusing on the information that advanced practice nurses and Physician Assistants specifically need for safe and effective prescribing. Three introductory chapters provide foundational content for new prescribers in the areas of prescriptive authority, rational drug selection, prescription writing, and promoting positive outcomes of drug therapy. Core drug chapters are focused on the drugs that prescribers will most commonly see in clinical practice.
• Introductory chapters tailored to the specific needs of prescribers cover topics such as prescriptive authority, rational drug selection and prescription writing, and promoting positive outcomes of drug therapy.
• Carefully focused pharmacotherapeutic content reflects the drugs most commonly seen and used by prescribers, with emphasis not on the first drug discovered or developed in each class but on the agents most often used today. Primary care drugs are addressed first in each chapter as appropriate, followed by acute care drugs.
• UNIQUE! Prescriber-focused pedagogical aids further reinforce the most important information for prescribers.
• Integrated coverage of Canadian trade names appears throughout the text and is highlighted with a familiar maple-leaf icon.
• Integrated coverage of interprofessional collaboration addresses the growing global interest in interprofessional collaboration and incorporates opportunities for interprofessional collaborative practice throughout.
New To This Edition:
• NEW! Genetic and Genomic Considerations chapter addresses our growing understanding of the importance of genetics and genomics in pharmacotherapeutic management of disease.
• NEW! Immunomodulators chapter covers the growing role of this innovative therapy in cancer treatment.
• NEW! Increased emphasis on the needs of prescribers includes new Key Prescribing Considerations specifically tailored for advanced practice nurses (APNs) and Physician Assistants (PAs), revised introductory disease content, and refocused illustrations.
• NEW! Expanded delineation of acute care drugs now extends to the cardiac, neurologic, hypertension, and male and female reproductive chapters.
• NEW! Significantly revised content on laboratory drug monitoring has been refocused on the needs of APNs and PAs
• NEW! Updated content on drug legislation, opioid addiction, and legalized marijuana addresses these key areas of change for prescribers.
• NEW! Illustrations, tables, and boxes have been substituted for text to highlight treatment guidelines (including decision-making algorithms) and drug mechanisms of action.
• NEW! Improved legibility includes the elimination of "small type" and a more user-friendly graphic design.
• NEW! Updated content covers the areas of drug legislation, opioid addiction, marijuana.
• Laura Rosenthal, DNP, ACNP, Associate Professor, College of Nursing, University of Colorado, Anschutz Medical Campus, Denver, Colorado.
• Jacqueline Burchum, DNSc, APRN, BC, Associate Professor, College of Nursing, Department of Advanced Practice and Doctoral Studies, University of Tennessee Health Science Center, Memphis, Tennessee