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133,38 ۥ PART I INTRODUCTION 1
1 Lipids and Lipidomics 3
2 Mass Spectrometry for Lipidomics 21
3 Mass Spectrometry-Based Lipidomics Approaches 53
4 Variables in Mass Spectrometry for Lipidomics 89
5 Bioinformatics in Lipidomics 121
• PART II CHARACTERIZATION OF LIPIDS 151
6 Introduction 153
7 Fragmentation Patterns of Glycerophospholipids 173
8 Fragmentation Patterns of Sphingolipids 201
9 Fragmentation Patterns of Glycerolipids 217
10 Fragmentation Patterns of Fatty Acids and Modified Fatty Acids 229
11 Fragmentation Patterns of other Bioactive Lipid Metabolites 243
12 Imaging Mass Spectrometry of Lipids 259
• PART III QUANTIFICATION OF LIPIDS IN LIPIDOMICS 281
13 Sample Preparation 283
14 Quantification of Individual Lipid Species in Lipidomics 305
15 Factors Affecting Accurate Quantification of Lipids 335
16 Data Quality Control and Interpretation 353
• PART IV APPLICATIONS OF LIPIDOMICS IN BIOMEDICAL AND BIOLOGICAL RESEARCH 377
17 Lipidomics for Health and Disease 379
18 Plant Lipidomics 405
19 Lipidomics on Yeast and Mycobacterium Tuberculosis 427
20 Lipidomics on Cell Organelle and Subcellular Membranes 443
INDEX
Covers the area of lipidomics from fundamentals and theory to applications
• Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics
• Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids
• Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation
• Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes
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