LIVER DISEASE IN CHILDREN

Table of Contents
Preface
Part I. Pathophysiology of Pediatric Liver Disease:
1. Liver development Yiwei Zong and Joshua R. Friedman
2. Functional development of the liver Frederick J. Suchy
3. Mechanisms of bile formation and cholestasis Nitika A. Gupta and Saul J. Karpen
4. Acute liver failure in children Robert H. Squires and Estella M. Alonso
5. Cirrhosis and chronic liver failure Evelyn K. Hsu and Karen F. Murray
6. Portal hypertension Benjamin L. Shneider
7. Laboratory assessment of liver function and injury in children Vicky Lee Ng
Part II. Cholestatic Liver Disease:
8. Approach to the infant with cholestasis Amy Feldman and Frederick J. Suchy
9. Medical and nutritional management of cholestasis in infants and children Andrew P. Feranchak, Frederick J. Suchy and Ronald J. Sokol
10. Neonatal hepatitis and congenital infections Philip Rosenthal
11. Biliary atresia and other disorders of the extrahepatic bile ducts William F. Balistreri, Jorge A. Bezerra and Frederick C. Ryckman
12. Neonatal jaundice and disorders of bilirubin metabolism Mark Bartlett and Glenn R. Gourley
13. Familial hepatocellular cholestasis Frederick J. Suchy, Shikha S. Sundaram and Benjamin L. Shneider
14. Alagille syndrome Binita M. Kamath, Nancy B. Spinner and David A. Piccoli
15. Intestinal failure associated liver disease Jason Soden and Ronald J. Sokol
16. Disease of the gallbladder in infancy, childhood, and adolescence Frank W. DiPaola and James E. Heubi
Part III. Hepatitis and Immune Disorders:
17. Hepatitis A and hepatitis E virus infection Philip Rosenthal
18. Hepatitis B virus infection Mei-Hwei Chang
19. Hepatitis C virus infection Maureen M. Jonas
20. Autoimmune hepatitis Nanda Kerkar and Cara L. Mack
21. Sclerosing cholangitis Alexander G. Miethke and William F. Balistreri
22. Drug-induced liver disease Eve A. Roberts
23. Liver disease in immunodeficiencies Nedim Hadžic
Part IV. Metabolic Liver Disease:
24. Laboratory diagnosis of inborn errors of metabolism Piero Rinaldo
25. a1-antitrypsin deficiency David H. Perlmutter
26. Cystic fibrosis liver disease Meghana Sathe and Andrew P. Feranchak
27. Inborn errors of carbohydrate metabolism Rana F. Ammoury and Fayez K. Ghishan
28. Copper metabolism and copper storage disorders Ronald J. Sokol
29. Iron storage disorders Michael R. Narkewicz and Peter F. Whittington
30. Heme biosynthesis and the porphyrias Robert J. Desnick, Manisha Balwani and Karl E. Anderson
31. Tyrosinemia Grant Mitchell, Pierre A. Russo, Josée Dubois and Fernando Alvarez
32. Lysosomal storage disorders T. Andrew Burrow and Gregory A. Grabowski
33. Disorders of bile acid synthesis and metabolism Kenneth D. R. Setchell
34. Inborn errors of fatty acid oxidation Melanie B. Gillingham and Robert B. Steiner
35. Mitochondrial hepatopathies Ronald J. Sokol
36. Nonalcoholic fatty liver disease in children Rohit Kohli, Kevin E. Bove and Stavra A. Xanthakos
37. Peroxisomal diseases Paul A. Watkins and Kathleen B. Schwarz
38. Urea cycle disorders Derek Wong and Stephen Cederbaum
Part V. Other Considerations and Issues in Pediatric Hepatology:
39. Bacterial, parasitic, and fungal infections of the liver Donald A. Novak, Gregory Y. Lauwers and Richard L. Kradin
40. Systemic disease and the liver Kathleen M. Campbell
41. Fibrocystic liver disease Ronen Arnon, Maureen M. Jonas, Antonio R. Perez-Atayde and Frederick J. Suchy
42. Tumors of the liver Dolores López-Terrada and Milton J. Finegold
43. Liver transplantation in children: indications and surgical aspects M. Kyle Jensen, Maria H. Alonso, Jaimie D. Nathan, Frederick C. Ryckman, Gregory M. Tiao and William F. Balistreri
44. Liver transplantation in children: post-transplant care Estella M. Alonso and Riccardo A. Superina
Index.

Description
The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. As in the previous editions, it offers an integrative approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. All of the chapters are written by international experts and address the unique pathophysiology, manifestations and management of these disorders. This edition of the landmark text features extended coverage of viral hepatitis, metabolic liver disease, fatty liver disease and liver transplantation, including a new chapter on post-transplant care and outcomes. All of the chapters have been updated to reflect changing epidemiology and recent advances in molecular medicine and genomics. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
LY/Disease of the Liver and Biliary System in Children, 3rd Edition/Blackwell/2008/expensive, more concise and aimed at a lower level WYLLIE and HYAMS/Pediatric Gastrointestinal and Liver Disease, 4th Edition/Elsevier/2011/covers all pediatric GI disorders and only superficially covers the liver KLEINMAN et al./Walker's Pediatric Gastrointestinal Disease, 5th Edition/McGraw-Hill/2008/covers all GI disorders

Authors
Frederick J. Suchy, University of Colorado Medical Center
Frederick J. Suchy, MD is Chief Research Officer and Director, The Children's Hospital Research Institute, Children's Hospital Colorado. He is also Professor of Pediatrics and Associate Dean for Child Health Research, University of Colorado School of Medicine, Aurora, CO, USA.

Ronald J. Sokol, University of Colorado Medical Center
Ronald J. Sokol, MD is Professor and Vice Chair of Pediatrics, Section Head, Gastroenterology, Hepatology and Nutrition, Director, Colorado Clinical and Translational Sciences Institute, and holds the Arnold Silverman MD Chair in Digestive Health, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.

William F. Balistreri, University of Cincinnati College of Medicine
William F. Balistreri, MD is Director Emeritus of the Pediatric Liver Care Center, Medical Director Emeritus, Liver Transplantation, and Dorothy M. M. Kersten Professor of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition at the Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Reviews & endorsements
Review of previous edition: 'The essential pediatric hepatology textbook.' New England Journal of Medicine
Review of previous edition: 'Well written and organized … builds on a strong scientific foundation and effectively bridges pathophysiologic principles with clinical practice, providing authoritative updated reviews on all topics relevant to the discipline. The textbook is the premier reference in the field and should be truly enjoyed by primary care practitioners, gastroenterologists, hepatologists, and anyone genuinely interested in the care of children with liver disease.' Journal of the American Medical Association
Review of previous edition: 'The text is accompanied by an excellent selection of color plates and is generally well illustrated throughout … the authors are to be congratulated for tapping the writing skills of some of the foremost experts in pediatric hepatology for the text.' Pediatric Gastroenterology