LIVER ELASTOGRAPHY. CLINICAL USE AND INTERPRETATION

1. Introduction to Liver Stiffness: A Novel Parameter for the Diagnosis of Liver Disease
2. Liver Stiffness and Its Measurement
3. Liver Stiffness Measurement Using Vibration-Controlled Transient Elastography
4. Characterizing Liver Stiffness with Acoustic Radiation Force
5. Two Dimensional Shear Wave Elastography/Supersonic Shear Imaging
6. Liver Magnetic Resonance Elastography: Clinical Use and Interpretation
7. Liver Stiffness Measurements in Small Animals
8. Introduction to Fibrosis Assessment by Liver Stiffness in Different Etiologies
9. Fibrosis Assessment in Patients with HCV or HBV Chronic Infection
10. Fibrosis Assessment in Patients with NAFLD
11. Liver Stiffness in Alcoholic Liver Disease
12. Liver and Spleen Stiffness in Schistosomiasis
13. Screening for Cystic Fibrosis Using Liver Stiffness Measurements
14. Role of Liver Stiffness in Hematological Disorders: Assessment of Sinusoidal Obstruction Syndrome, Budd–Chiari Syndrome, and Treatment Complications
15. Liver and Spleen Stiffness in Patients with Portal Vein Thrombosis
16. Liver Stiffness in Autoimmune Hepatitis
17. Liver Fibrosis Assessment in Adults with Alpha1-Antitrypsin Deficiency
18. Fibrosis and Prognosis Assessment Using Liver Stiffness in Patients with PBC and PSC
19. Liver Stiffness in Patients with Hereditary Hemochromatosis and Secondary Iron Overload
20. Liver Stiffness in Patients with Wilson’s Disease
21. Introduction to Confounders of Elevated Liver Stiffness
22. Histological Confounders of Liver Stiffness
23. Liver Stiffness Elevation in Patients with Heart Failure and Liver Congestion
24. Modulation of Liver Stiffness by Arterial and Portal Pressure
25. Liver Stiffness and Cholestasis
26. Liver Stiffness and Nutrition
27. Genetic Confounders of Liver Stiffness and Controlled Attenuation Parameter
28. Liver Stiffness and Acute Liver Failure
29. Liver Stiffness and Pregnancy
30. Liver Stiffness and Important Clinical Endpoints
31. Liver and Spleen Stiffness to Predict Portal Hypertension and Its Complications
32. Liver Stiffness and Hepatic Decompensation
33. Spleen Stiffness to Liver Stiffness Ratio and Disease Etiology
34. Prediction of HCC Using Liver Stiffness Measurements
35. Liver Stiffness as a Predictor for Survival
36. Role of Liver Stiffness in the Management of Liver Transplantation: First Experience and Clinical Practice
37. Steatosis Assessment by Controlled Attenuation Parameter (CAP™)
38. Steatosis Assessment with Controlled Attenuation Parameter (CAP) in Various Diseases
39. Liver Steatosis (CAP) as Modifier of Liver Stiffness
40. Introducing to Liver Stiffness Measurement in Clinical Practice
41. Quality Criteria for Liver Stiffness Measurement by Transient Elastography
42. Interpretation of Shear Wave Propagation Maps (Elastogram) Using Transient Elastography
43. Liver Stiffness Measurement in Patients with Hepatic Versus Non-hepatic Ascites
44. Use of XL Probe in Obese and Non-obese Patients
45. Comparison of Various Elastographic Techniques for Liver Fibrosis Assessment
46. Adaptation of Liver Stiffness Cutoff Values to Inflammation, Cholestasis, and Congestion
47. Screening for Liver Fibrosis in General or At-Risk Populations Using Transient Elastography
48. Elastography in Combination with Other Biomarkers: Role of Algorithms
49. Fibrosis Assessment via Liver Stiffness Measurements: How Many Patients Are Spared from a Liver Biopsy?
50. Performance of Liver and Spleen Stiffness Measurements in Predicting Postoperative Hepatic Decompensation After HCC Resection
51. Liver Stiffness Changes in Patients with Established Liver Cirrhosis
52. Therapeutic Monitoring of Portal Pressure Lowering Drugs Using Liver Stiffness
53. Clinical Cases: Application and Interpretation of Liver Stiffness
54. Introduction to the Molecular Basis of Liver Stiffness and Its Relation to Mechano-signaling
55. Stiffness and Hepatocytes Function In Vitro
56. Liver Mechanics and the Profibrotic Response at the Cellular Level
57. Role of Sinusoidal Pressure and Arterialization in Driving Fibrosis Progression
58. Future Applications and Directions of Liver Stiffness Studies

This is the first comprehensive book on the new elastographic techniques discussing the early assessment of liver fibrosis. The book covers all aspects of measuring liver stiffness starting from the methodology, the molecular basis of liver stiffness elevation up to current clinical algorithms and interpretation. Future directions and novel implications that go beyond diagnosis but are relevant for understanding of liver cirrhosis per se are also discussed in detail.
Liver Elastography, is an essential companion for hepatologists and gastroenterologists that provides an overview of its basic principles and gives a detailed account of how to use elastrography in clinical practice.

Features
• First book focusing on liver stiffness whose measurement by elastographic techniques has revolutionized diagnosis of fibrosis and liver diseases within the last 10 years
• Gives a comprehensive presentation of all aspects of elastographic techniques – state of the art
• Provides discussion of new applications going beyond liver diseases

Author
Sebastian Mueller is Professor of Medicine and the current vice head of the Department of Internal Medicine at Salem Medical Center and the Co-Director of the Center for Alcohol Research at the University of Heidelberg. He studied medicine in Leipzig, Denver and Strasbourg and obtained a PhD in Biophysics in 1994. He was gastroenterology resident and consultant in Heidelberg, postdoctoral Humboldt fellow at USC in Los Angeles and lecturer at the BIDMC/Harvard Medical School from 2005-2007. Prof. Mueller’s translational research includes the pathophysiology, genetics, diagnosis and treatment of liver diseases, namely alcoholic liver disease. His longterm basic research interests focus on hepatic iron metabolism and redox regulation. Prof. Mueller has published more than 100 original articles. Since 2017, he is president of the European Society of Biomedical Research on Alcoholism (ESBRA).