LONG-LIVED PROTEINS IN HUMAN AGING AND DISEASE

LONG-LIVED PROTEINS IN HUMAN AGING AND DISEASE

Editorial:
WILEY-BLACKWELL
Año de edición:
Materia
Ciencias - biología
ISBN:
978-3-527-34728-5
Páginas:
224
N. de edición:
1
Idioma:
Inglés
Disponibilidad:
Disponible en 2-3 semanas

Descuento:

-5%

Antes:

121,00 €

Despues:

114,95 €

Preface
01 Long-lived cells and long-lived proteins in the human body
02 Imaging Mass Spectrometry of Long-Lived Proteins
03 Eye lens crystallins: remarkable long-lived proteins
04 Spontaneous breakdown of long-lived proteins in aging and their implications in disease
05 Modifications of Long-lived Proteins that affect Protein Solubility
06 Degradation of Long-lived proteins as a cause of Autoimmune diseases
07 How Isomerization and Epimerization in Long-lived Proteins Affects Lysosomal Degradation and Proteostasis
08 The Maillard Reaction. Protein Modification by Ascorbic Acid

This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.