LYMPHEDEMA. COMPLETE MEDICAL AND SURGICAL MANAGEMENT

Lymphedema is a huge global health problem, with up to 7 million sufferers in the U.S. alone. Lymphedema: Complete Surgical and Medical Management is one of the first books to cover the state of the field, covering both surgical and non-surgical treatment.
The book is divided into four sections that discuss current concepts in lymphedema, diagnosis, treatment, and further directions for research. It begins with chapters on anatomy and embryology, discusses the physiology of the lymphatic system, and examines the pathophysiology of primary and secondary lymphedema. It reviews risk factors in breast cancer, examines lymphedema in paediatrics, and explores sentinel node biopsy. The book also describes psychological and dermatological implications.
Next, the authors discuss diagnosis modalities such as duplex ultrasonography, ICG lymphography, magnetic resonance imaging, and other diagnostic tools. Chapters also explore differential lymph node mapping and clinical staging.
The third section provides a history of lymphedema treatment and an overview of various past and present treatments in India and China. It explores pharmacological options, excisional approaches, liposuction, and venous implantation methods. Lymphatic grafts and surgical treatments are also considered.
The final section discusses current research and possible areas for future inquiry in this area. The authors discusss animal modeling for lymphedema research and molecular approaches to the management of lymphedema. They examine the relationship between fat tissue and lymphangiogenesis, quality of life issues, and future directions for lymphedema management.
The book uses a consistent templated format, is well-illustrated in full color throughout, and includes a DVD with surgical video clips. With U.S., European, and Asian-Pacific contributors, it provides a truly global approach.

Features
- Comprehensive coverage of lymphedema—from diagnosis to treatment to future directions, such as molecular approaches
- Focusses on medical and surgical management
- Includes operative videos with key details of main surgical approaches
- Published in full color with over 500 illustrations
- Includes a bonus eBook version compatible with a wide range of devices



Author
Peter Neligan, MD is a University of Washington professor of surgery and director of the Center for Reconstructive Surgery at UW Medical Center, as well as an acknowledged expert in the field of reconstructive microsurgery.
Originally from Ireland, he completed his surgical training there before moving to Toronto, Canada in 1983 for further training in microvascular surgery. He developed his interest in reconstructive microsurgery, concentrating on post-oncologic reconstruction.
Dr. Neligan served as chair of the division of plastic surgery at the University of Toronto from 1996 to 2007 and was appointed Wharton Chair in Reconstructive Plastic Surgery at that institution. He was recruited to the University of Washington in 2007 to establish the Center for Reconstructive Surgery.
The scope of his work includes complex reconstructions of all kinds of major defects, as well as microvascular breast reconstruction and head and neck reconstruction. He also has an interest in composite tissue allotransplantation.

Contents
- CURRENT CONCEPTS IN LYMPHEDEMA
Lymphedema: Lack of Solutions to a Clinical Problem
Lymphedema and Its Impact on Quality of Life
Measuring Quality of Life

- ANATOMY, PHYSIOLOGY, AND LYMPHANGIOGENESIS
Embryology
Lymphatic Pathways
Applied Anatomy
Lymphangiogenesis
Impact of Genetics on the Development of the Lymphatic System
Relationship Between Fat Tissue and Lymphangiogenesis
Lymphatic Malformations
Immune Regulation by the Peripheral Lymphatics

- PATHOPHYSIOLOGY AND CLINICAL PRESENTATION
Pathophysiology of Primary Lymphedema
Pathophysiology of Secondary Lymphedema
Clinical Presentation of Secondary Lymphedema of the Lower Leg
Filaria
Lymphedema in Pediatrics
Venous Failure
Lymphedema Risk Factors in Breast Cancer
Sentinel Lymph Node Biopsy Outcomes

- DIAGNOSIS OF LYMPHEDEMA
Cause and Classification of Lymphatic Disorders
Approach to Diagnosis, Including Differential Diagnosis and Misdiagnosis
Biomarkers
Clinical Staging
Measuring Methods
Lymph Pressure and Flow Measurements
Radionuclide Lymphoscintigraphy
ICG Lymphography
Magnetic Resonance Lymphangiography

- CURRENT TREATMENT OF LYMPHEDEMA
Conservative Treatments for Lymphedema
Pharmacological Treatment of Lymphedema
Excisional Approaches
Liposuction
Multiple Lymphatic-Venous Anastomoses and Multiple Lymphatic-Venous-Lymphatic Anastomoses
Lymphatic Grafts
Lymphatico Venular Anastomosis
Vascularized Lymph Node Transfer
Differential Lymph Node Mapping
Local Flaps and Vascularized Lymph Node Transfer
Transverse Myocutaneous Gracilis with Vascularized Lymph Node Transfer
L.Y.M.P.H.A. Concept
Combined Surgical Treatment for Breast Cancer–Related Lymphedema
Interventional Timing
Lymphedema Complications and Their Treatment
Treatment of Lymphedema in India
Treatment of Lymphedema in China

- RESEARCH AND FUTURE DIRECTIONS
Animal Models of Lymphedema
Stem Cells and Possible Future Use in Lymphedema Management
Lymphedema Frameworks: Toward Improved Patient Outcomes