LYSOSOMES: BIOLOGY, DISEASES, AND THERAPEUTICS

LYSOSOMES: BIOLOGY, DISEASES, AND THERAPEUTICS

Editorial:
WILEY-BLACKWELL
Año de edición:
Materia
Farmacia
ISBN:
978-1-118-64515-4
Páginas:
544
N. de edición:
1
Idioma:
Inglés
Disponibilidad:
Disponible en 2-3 semanas

Descuento:

-5%

Antes:

174,72 €

Despues:

165,98 €

1 Lysosomes: An Introduction 1
2 Lysosome Biogenesis and Autophagy 7
3 Multivesicular Bodies: Roles in Intracellular and Intercellular Signaling 33
4 Lysosomes and Mitophagy 51
5 Lysosome Exocytosis and Membrane Repair 63
6 Role of Lysosomes in Lipid Metabolism 87
7 TFEB, Master Regulator of Cellular Clearance 101
8 Lysosomal Membrane Permeabilization in Cell Death 115
9 The Lysosome in Aging-Related Neurodegenerative Diseases 137
10 Lysosome and Cancer 181
11 The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases 209
12 Lysosome-Related Organelles: Modifications of the Lysosome Paradigm 239
13 Autophagy Inhibition as a Strategy for Cancer Therapy 279
14 Autophagy Enhancers, are we there Yet? 315
15 Pharmacological Chaperones as Potential Therapeutics for Lysosomal Storage Disorders: Preclinical Research to Clinical Studies 357
16 Endosomal Escape Pathways for Delivery of Biologics 383
17 Lysosomes and Antibody–Drug Conjugates 409
18 The Mechanisms and Therapeutic Consequences of Amine-Containing Drug Sequestration in Lysosomes 423
19 Lysosome Dysfunction: an Emerging Mechanism of Xenobiotic-Induced Toxicity 445
20 Lysosomes and Phospholipidosis in Drug Development and Regulation 487

This up-to-date, comprehensive book about lysosomes discusses their functions, properties, and roles in disease, drug development, and therapeutics. Pulling together perspectives from various fields, including biology, toxicology, and pharmacology; this book illustrates the potential of lysosomes beyond their cellular function, focusing on disease mechanisms and drug targeting. The book is divided into two sections. The first covers basic cell biology, biochemistry and physiological processes. It also includes chapters on the lysosomes role in cancer, cell death, and aging. The second section explores lysosomes in various aspects of drug development and toxicity. Chapters discuss therapeutic interventions on autophagy, ADC delivery and efficacy, pharmacokinetics, and drug-induced toxicity. Incorporating a broad range of information, strategies, mechanisms, and novel discoveries in the field; this book integrates key aspects of lysosomes to present an understanding of their roles, potential, and future prospects.