MANDELL, DOUGLAS, AND BENNETT'S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES + EXPERT CONSULT

Table of Contents
Part I Basic Principles in the Diagnosis and Management of Infectious Diseases
Section A. Microbial Pathogenesis
1. A Molecular Perspective of Microbial Pathogenicity
2. Microbiome of Local Sites and their Unique Biology
3. Prebiotics, Probiotics and Synbiotics
Section B. Host Defense Mechanisms
4. Innate (General or Nonspecific) Host Defense Mechanisms
5. Adaptive Immunity: Antibodies and Immunodeficiencies
6. Mucosal Immunity
7. Granulocytic Phagocytes and Deficiency States
8. Complement and Deficiencies
9. Human Genetics and Infection
10. Nutrition, Immunity, and Infection
11. Evaluation of the Patient with Suspected Immunodeficiency and Other Host Defense Defects
Section C. Epidemiology of Infectious Disease
12. Epidemiologic Principles
13. Emerging and Reemerging Infectious Disease Threat
14. Bioterrorism: An Overview
Section D. Clinical Microbiology
15. The Clinician and the Microbiology Laboratory
Section E. Anti-Infective Therapy
16. Principles of Anti-infective Therapy
17. Molecular Mechanisms of Antibiotic Resistance in Bacteria
18. Pharmacokinetics and Pharmacodynamics of Anti-infective Agents
19. Penicillins
20. Cephalosporins
21. Other ß-Lactam Antibiotics
22. Antibiotic Allergy
23. Fusidic Acid
24. Aminoglycosides
25. Tetracyclines and Chloramphenicol
26. Rifamycins
27. Metronidazole
28. Macrolides, Clindamycin, and Ketolides
29. Glycopeptides (Vancomycin and Teicoplanin), Streptogramins (Quinupristin-Dalfopristin), and Lipopeptides (Daptomycin)
30. Polymyxins (Polymyxin B and Colistin)
31. Oxazolidinones
32. Sulfonamides and Trimethoprim
33. Quinolones
34. Unique Antibacterial Agents
35. Urinary Tract Agents: Nitrofurantoin and Methenamine
36. Topical Antibacterials
37. Antimycobacterial Agents
38. Drugs Active Against Fungi, Pneumocystis and Microsporidia
39. Drugs for Malaria
40. Drugs for Parasites Other Than Malaria
41. Drugs for Helminths
42. Antiviral Drugs General Principles
43. Antivirals Against Influenza and Other Respiratory Viruses
44. Antivirals Against Herpes Viruses
45. Antivirals Against Hepatitis Viruses
46. Other Antiviral Drugs
47. Immunomodulators
48. Hyperbaric Oxygen
49. Complementary and Alternative Medicines for Infectious Diseases
50. Antimicrobial Management: Cost and Resistance
51. Interpretation of Clinical Trials of Antimicrobial Agents
52. Outpatient Parenteral Antimicrobial Therapy
53. Tables of Antimicrobial Agent Pharmacology
Part II Major Clinical Syndromes
Section A. Fever
54. Temperature Regulation and the Pathogenesis of Fever
55. Fever of Unknown Origin
56. The Acutely Ill Patient with Fever and Rash
Section B. Upper Respiratory Tract Infections
57. The Common Cold
58. Pharyngitis
59. Acute Laryngitis
60. Acute Laryngotracheobronchitis (Croup)
61. Otitis Externa, Otitis Media, and Mastoiditis
62. Sinusitis
63. Epiglottitis
64. Infections of the Oral Cavity, Neck, and Head
Section C. Pleuropulmonary and Bronchial Infections
65. Acute Bronchitis
66. Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, and Acute Exacerbations
67. Bronchiolitis
68. Acute Pneumonia
69. Empyema and Pleural Effusion
70. Lung Abscess
71. Chronic Pneumonia
72. Cystic Fibrosis
Section D. Urinary Tract Infections
73. Urinary Tract Infections
Section E. Sepsis
74. Sepsis, Severe Sepsis, and Septic Shock
Section F. Intra-Abdominal Infection
75. Peritonitis and Intraperitoneal Abscesses
76. Infections of the Liver and Biliary System
77. Pancreatic Infections
78. Splenic Abscess
79. Appendicitis
80. Diverticulitis and Typhlitis
Section G. Cardiovascular Infections
81. Endocarditis and Intravascular Infections
82. Prosthetic Valve Endocarditis
83. Infections of Non-Valvular Cardiovascular Devices
84. Prophylaxis of Infective Endocarditis
85. Myocarditis and Pericarditis
86. Mediastinitis
Section H. Central Nervous System Infections
87. Approach to the Patient with Central Nervous System Infection
88. Acute Meningitis
89. Chronic Meningitis
90. Encephalitis, Myelitis, and Neuritis
91. Brain Abscess
92. Subdural Empyema, Epidural Abscess, and Intracranial Suppurative Thrombophlebitis
93. Cerebrospinal fluid shunt infections
Section I. Skin and Soft Tissue Infections
94. Cellulitis, Necrotizing Fasciitis and Subcutaneous Tissue Infections
95. Myositis
96. Lymphadenitis and Lymphangitis
Section J. Gastrointestinal Infections and Food Poisoning
97. Principles and Syndromes of Enteric Infection
98. Esophagitis
99. Nausea, Vomiting, and Noninflammatory Diarrhea
100. Inflammatory Enteritides
101. Enteric Fever and Other Causes of Abdominal Symptoms with Fever
102. Food Poisoning
103. Tropical Sprue/Enteropathy
Section K. Bone and Joint Infections
104. Infectious Arthritis
105. Osteomyelitis
106. Orthopedic Implant Infections
Section L. Diseases of the Reproductive Organs and Sexually Transmitted Diseases
107. Genital Skin and Mucous Membrane Lesions
108. Urethritis
109. Vulvovaginitis and Cervicitis
110. Infections of the Female Pelvis
111. Prostatitis, Epididymitis, and Orchitis
Section M. Eye Infections
112. Introduction to Ocular Infections
113. Microbial Conjunctivitis
114. Microbial Keratitis
115. Endophthalmitis
116. Infectious Causes of Uveitis
117. Periocular Infections
Section N. Hepatitis
118. Hepatitis
Section O. Acquired Immunodeficiency Syndrome
119. Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
120. Epidemiology and Prevention of Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus Infection
121. Diagnosis of Human Immunodeficiency Virus Infection
122. The Immunology of Human Immunodeficiency Virus Infection
123. General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including the Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic and Cardiac Diseases)
124. Pulmonary Manifestations of Human Immunodeficiency Virus Infection
125. Gastrointestinal and Hepatobiliary Manifestations of Human Immunodeficiency Virus Infection
126. Neurologic Diseases Caused by Human Immunodeficiency Virus-1 and Opportunistic Infections
127. Human Immunodeficiency Virus Infection in Women
128. Pediatric Human Immunodeficiency Virus Infection
129. Antiretroviral Therapy for Human Immunodeficiency Virus Infection
130. Management of Opportunistic Infections Associated with Human Immunodeficiency Virus Infection
131. Vaccines for Human Immunodeficiency Virus-1 Infection
Section P. Miscellaneous Syndromes
132. Chronic Fatigue Syndrome
Part III Infectious Diseases and Their Etiologic Agents
Section A. Viral Diseases
133. Biology of Viruses and Viral Diseases
134. Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox
135. Other Poxviruses That Infect Humans: Parapoxviruses, Molluscum Contagiosum, and Tanapox
Section B. Herpesviridae
136. Introduction

After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see.
Features:
Get the answers to any questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other ID resource.
Apply the latest knowledge with updated diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses.

New To This Edition:
Put the latest knowledge to work in your practice with new or completely revised chapters on Influenza (new pandemic strains); New Middle East Respiratory Syndrome (MERS) Virus; Probiotics; Antibiotics for resistant bacteria; Antifungal drugs; New Antivirals for hepatitis B and C; Clostridium difficile treatment; Sepsis; Advances in HIV prevention and treatment; Viral gastroenteritis; Lyme Disease; Helicobacter pylori; Malaria; Infections in immunocompromised hosts; Immunization (new vaccines and new recommendations); and Microbiome.
Benefit from fresh perspectives and expanded global insights from an expanded team of American and International contributors. Martin Blaser, MD, a leading expert and Muriel G. and George W. Singer Professional of Translational Medicine at New York University School of Medicine, joins veteran PPID editors John E. Bennett, MD, and Raphael Dolin, MD to continue a legacy of excellence.
Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult.
Access the full text on Expert Consult. A thorough and regularly scheduled update program ensures your access to new developments in the field, advances in therapy, and more timely information.

By John E. Bennett, MD, Adjunct Professor of Medicine, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine; Director, Infectious Diseases Training Program, NIH Office of Clinical Research Training and Medical Education, Bethesda, Maryland ;Raphael Dolin, MD, Maxwell Finland Professor of Medicine (Microbiology & Molecular Genetics), Harvard Medical School; Attending Physician, Beth Israel Deaconess Medical Center Brigham and Women's Hospital, Boston, Massachusetts and Martin J. Blaser, MD, Muriel G. and George W. Singer Professor of Translational Medicine, Professor of Microbiology, Director, Human Microbiome Program, Departments of Medicine and Microbiology, New York University School of Medicine, Langone Medical Center, New York, New York