MASS SPECTRAL AND GC DATA OF DRUGS, POISONS, PESTICIDES, POLLUTANTS, AND THEIR METABOLITES, 5TH EDIT

VOLUME 1
• INTRODUCTION
• EXPERIMENTAL SECTION
Origin and choice of samples
Sample preparation
GC-MS apparatus
Determination of retention indices
Systematic toxicological analysis (STA) of several classes of drugs and their metabolites by GC-MS
Application of the electronic versions of this handbook using macros or AMDIS
Quantitative determination
• CORRELATION BETWEEN STRUCTURE AND FRAGMENTATION
Principle of electron-ionization mass spectrometry (EI-MS)
Correlation between fundamental structures or side chains and fragment ions
• FORMATION OF ARTIFACTS
Artifacts formed by oxidation during extraction with diethyl ether
Artifacts formed by thermolysis during GC (GC artifacts)
Artifacts formed during acid hydrolysis
• TABLE OF ATOMIC MASSES
• TABLE OF ABBREVIATIONS
• REFERENCES
• TABLES OF COMPOUNDS
• MASS SPECTRA (m/z 30 -
299)

VOLUME 2
MASS SPECTRA (m/z 300 and higher)

The world`s most comprehensive reference for clinical and forensic toxicologists has once more been extensively updated: 2,000 data sets have been added for a total of 10,430 spectra of potentially harmful substances, including 7,800 from metabolites. In two hardbound volumes, the printed atlas contains a comprehensive listing of full reference mass spectra in order or molecular mass with the structural formula, exact mass, GC retention times and other experimental data that are relevant to the analytical toxicologist. To aid in compound identification, all substances are classified according to their toxicological categories.
In addition, volume 1 contains an overview on experimental methods, plus a compound index by name.
An electronic database for use with all major mass spectrometers is also available. For details, please visit www.wiley.com/go/databases.

Author Information
• Hans H. Maurer is full professor and head of the department of Experimental & Clinical Toxicology at the Saarland University in Homburg (Saar), Germany. His main two areas of research are analytical toxicology (GC-MS, LC-(HR)MS) and toxicokinetics of xenobiotics. He has published over 260 original papers and 30 invited reviews. He is editorial board member of over ten journals in his field. He received several scientific awards, including the Young Investigator Award of the Homburg Medical Faculty in 1983, the Irving Sunshine Award for Outstanding Contributions to Clinical Toxicology of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) in Vancouver 1997, the Alan Curry Lifetime Achievement Award of The International Association of Forensic Toxicologists (TIAFT) for Outstanding Contributions to Forensic Toxicology in Melbourne 2003, and a honorary doctorate (Doctor honoris causa) of the University of Ghent in 2007. He was President of IATDMCT (2007-2009) and is executive board member of TIAFT (since 2005) and treasurer of GTFCh (since 1987).
In the late 1970s, he developed as PhD student of Prof. Karl Pfleger novel analysis procedures for identification and quantification of drugs, poisons and their metabolites in body samples. They introduced the mass spectrometry as gold standard into clinical and forensic toxicology. In 1985, they published the first edition of their unique handbook of GC and MS data together with their coworker Armin A. Weber, who was and is responsible for all technical and software developments, including the mass spectral data base that was initially developed from the printed collection. He is coauthor of several papers of his group and also of the Maurer/Wissenbach/Weber LC-MSn Library of drugs, poisons, and their metabolites as well as of the corresponding new Maurer/Meyer/Helfer/Weber LC-high resolution-MS/MS library.
• Karl Pfleger (who passed away in 2013) was the predecessor of Hans H. Maurer from 1967 until 1992. Under his far-seeing guidance, this mass spectral collection was initiated in the early 1980s. In 1987, Karl Pfleger received the Jean-Servais Stas Medal of the Gesellschaft für Toxikologische und Forensische Chemie (GTFCh) in Mosbach for his outstanding achievements in mass spectrometry in clinical toxicology.