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• Part I. Overview of the Mechanical Circulatory Support (MCS)
1. A History of Mechanical Circulatory Support
2. A Personalized History of Rotary Blood Pumps
3. Overview of Mechanical Circulatory Support Devices and Concepts
4. Physiology of Blood-pump Circulation in Heart Failure
5. Physiology of Blood Pump Circulation in Heart Failure
6. Engineering Requirements for Mechanical Circulatory Support Devices
7. Clinical Requirements for Mechanical Circulatory Support Devices
8. Engineering Perspectives for Mechanical Circulatory Support Devices
• Part II: Indications and Selection for Mechanical Circulatory Support
9. Patient Population and Selection Criteria for Mechanical Circulatory Support
10. Mechanical Circulatory Support Therapies; Right Timing and Prognosis Considerations
11. Perioperative Considerations in Left Ventricular Assist Device Placement
12. Left Ventricular Assist Devices: Management and Surgical Techniques
13. Mechanical Circulatory Support for Biventricular Failure: Patient Selection and Management Options
14. Status and Availability of a Total Artificial Heart
15. Extracorporeal Membrane Oxygenation Techniques and Modern Considerations
16. Less Invasive Extra-Pericardial Placement (LIEPP) of LVAD
• Part III. Parameters of Physiologic and Non-Physiologic Blood Flow
17. Pulsatile Mechanical Circulation, Physiology and Pump Technology
18. Pathophysiological Determinants Relevant in Blood Pump Control
19. End-Organ Physiology under Continuous Flow Mechanical Circulatory Support
20.Quantification of Pulsatility during Mechanical Circulatory Support
21. Pulsatility as an Option with Continuous-Flow Mechanical Circulatory Support Devices
• Part IV. Current Technology and Methods
22. Implantable Continuous-Flow Blood Pump Technology and Features
23. Partial Support with Mechanical Circulatory Support Devices
24. Percutaneous Mechanical Circulatory Support Technologies
25. Computational Fluid Dynamics for Mechanical Circulatory Support Device Development
26. Hemodynamic Modelling and Simulations for Mechanical Circulatory Support
27. Options for Modeling and Simulations Used in Mechanical Circulatory Support Development
• Part V. Evolving Technologies and Device Concepts
28. Emerging Continuous Flow Blood Pump Technologies
29. The Development of Advanced Ventricular Assist Device as a Next Generation Ventricular Assist Device
30. Cleveland Clinic Total Artificial Heart
31. The ReinVAD LVAD – Smart Technology to Enhance Long-Term Circulatory Support Therapy
32. EVAHEART 2 Left Ventricular Assist System: A Hemocompatible Centrifugal Pump with Physiological Pulsatility
33. A Novel Rotary Total Artificial Heart Using a Single Shuttling Impeller
34. New Mechanical Circulatory Device: TORVAD
35. BiVACOR Total Artificial Heart
36. The Penn State Pediatric Total Artificial Heart
37. CorWave LVAD: Insight Into Device Concept And Stage of Development
38. Progress on Total Artificial Heart for Pediatric Patients
39.Progress on Wireless LVAD and Energy Sources for Mechanical Circulatory Systems
• Part VI. Management Strategies and Limitations of MCS
40.Risk Factors for Mechanical Circulatory Support Use and Risk Assessment
41.Gastrointestinal Bleeding in Mechanical Circulatory Support Patients
42.Postoperative Management Strategies in Mechanical Circulatory Support Patients
43.Palliative Care in MCS patients: Insights into Current Practice and Outcomes
• Part VII. Future Perspectives
44.Clinical Demands and Challenges for Future Mechanical Circulatory Support Technologies
45.Smart Mechanical Circulatory Support Devices: Requirements and Perspectives
46.Novel Solutions for Patient Monitoring and Mechanical Circulatory Support Device Control.

This book provides a comprehensive overview of mechanical circulatory support of the failing heart in adults and children. The book uniquely combines engineering knowledge and the clinician’s perspective into a single resource, while also providing insights into current and future development of mechanical circulatory support technology, such as ventricular assist devices, the total artificial heart and catheter-based technologies for heart failure.Topics featured in this book include:The history of mechanical circulatory device development.Fundamentals of hemodynamics support.Clinical management of mechanical circulatory devices.Surgical implantation techniques.Current limitations of device therapies in advanced heart failure.Advanced and novel devices in the development pipeline.Opportunities for advancement in the field.Mechanical Support for Heart Failure: Current Solutions and New Technologies is a must-have resource for not only physicians, residents, fellows, and medical students in cardiology and cardiac surgery, but also clinical and basic researchers in biomedical engineering with an interest in mechanical circulatory support, heart failure, and new technological applications in medicine.

• Describes the fundamentals of mechanical circulatory support devices and their use in children and adults
• Discusses clinical management and implantation techniques
• Provides perspectives on blood pump technology from clinicians and engineers
• Examines the limitations of current technology, potential for improvements, and insights on future developments

• Jamshid H. Karimov, MD, PhD Adjunct Assistant Professor of Molecular Medicine Department of Biomedical EngineeringCleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityLerner Research InstituteCleveland Clinic
• Kiyotaka Fukamachi, MD, PhD Professor of Molecular MedicineDepartment of Biomedical EngineeringCleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityLerner Research InstituteCleveland
• Clinic Randall C Starling, MD, MPH, FACC, FAHA, FHFSA, FESC, FHFAProfessor of MedicineDepartment of Cardiovascular Medicine Kaufman Center for Heart FailureHeart and Vascular InstituteCleveland Clinic