MEDULLARY THYROID CANCER

1. History and Epidemiology
2. Initial Evaluation and Diagnosis of Medullary Thyroid Carcinoma
3. The Physiology of Serum Calcitonin and Carcinoembryonic Antigen in Medullary Thyroid Cancer
4. Cytology and Pathology: Pitfalls and Challenges
5. Molecular Mechanisms of Disease: The RET Proto-oncogene
6. Genetic Evaluation of the Patient with Medullary Thyroid Cancer
7. Preoperative Evaluation of the Patient with Medullary Thyroid Cancer
8. Inherited Medullary Thyroid Carcinoma: Indications and Technique of
9. Surgical Management of Inherited MTC: Therapeutic Thyroidectomy
10. Surgical Management of Parathyroid and Adrenal Glands in Inherited Medullary Thyroid Carcinoma
11. Surgical Management of Sporadic Medullary Thyroid Cancer (Extent of Thyroid Resection and the Role of Central and Lateral Neck Dissection)
12. Surgical Management of Invasive Medullary Thyroid Carcinoma
13. Importance of Thyroid Hormone Replacement Therapy in Patients with Medullary Thyroid Cancer
14. Medullary Thyroid Cancer: The Role of External Beam Therapy
15. Management of Patients with Metastatic Medullary Thyroid Carcinoma: The Role for Systemic Therapy
16. Ablative Therapies of the Liver and Bone in Medullary Thyroid Cancer
17. Emerging Therapies for Progressive Metastatic Medullary Thyroid Cancer
18. Follow-Up and
19. Surgical Management of Recurrent Medullary Thyroid Cancer

This text provides a comprehensive, contemporary review of this disease and serves as an important resource for clinicians and researchers with an interest in medullary thyroid cancer. The book reviews the initial management of the patient with thyroid nodules, including risk factors, appropriate genetic evaluation of suspected/known medullary thyroid cancer, and appropriate screening for diseases associated with inherited forms of medullary thyroid cancer, including primary hyperparathyroidism and pheochromocytomas. It includes an in-depth discussion of the optimal surgical management of patients with sporadic and inherited disease, those with locoregional metastases, distant metastases, and recurrent medullary thyroid cancer. The long-term follow-up and management of patients with medullary thyroid cancer is highlighted.
Medullary Thyroid Cancer will serve as a useful resource for all providers and researchers interested in this relatively rare and challenging malignancy. It highlights recent guidelines for the management of patients with medullary thyroid cancer and discusses controversies within the literature. All chapters are written by experts in the field and incorporate multiple disciplines, including Surgery (Endocrine Surgery, General Surgery, and Otolaryngology), Endocrinology, Radiology, Medical Oncology and Genetic Counseling.

Features
• Written by experts in the fields of multiple disciplines
• Provides a comprehensive, contemporary review of this disease
• Highlights recent guidelines for the management of patients with medullary thyroid cancer and discusses controversies within the literature

Authors
• Tracy S. Wang, MD, MPH. Associate Professor of SurgeryChief, Section of Endocrine SurgeryMedical College of WisconsinMilwaukee, WI USA
• Douglas B Evans, MDDonald C. Ausman Family Foundation Professor in Surgery and ChairMedical College of WisconsinMilwaukee, WI USA