MEDULLARY THYROID CARCINOMA. BIOLOGY, MANAGEMENT, AND TREATMENT OF SPORADIC AND HEREDITARY MTC. 2ND EDITION

MEDULLARY THYROID CARCINOMA. BIOLOGY, MANAGEMENT, AND TREATMENT OF SPORADIC AND HEREDITARY MTC. 2ND EDITION

Editorial:
SPRINGER
Año de edición:
Materia
Oncología
ISBN:
978-3-031-80395-6
Páginas:
307
N. de edición:
2
Idioma:
Inglés
Ilustraciones:
48
Disponibilidad:
Disponible en 2-3 semanas

Descuento:

-5%

Antes:

146,00 €

Despues:

138,70 €

After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.
Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC.
This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.

Features
• Provides a comprehensive overview of medullary thyroid carcinoma
• Explains the use of thyroidectomy and tyrosine kinase inhibitors
• Written by experts in the field