MERRITT’S NEUROLOGY. 14TH EDITION

• SECTION I GLOBAL BURDEN OF NEUROLOGIC DISEASE 1
1 Worldwide Epidemiology of Neurologic Disease 1
2 Global Delivery of Neurologic Care 9
• SECTION II APPROACH TO THE NEUROLOGIC PATIENT 15
3 Neurologic History Taking, Localization, and Differential Diagnosis 15
4 The Neurologic Examination 25
• SECTION III COMMON PROBLEMS IN NEUROLOGY 45
5 Dizziness, Vertigo, and Hearing Loss 45
6 Syncope 51
7 Seizures 57
8 Pain, Numbness, and Paresthesias 64
9 Headache and Facial Pain 70
10 Visual Disturbances 77
11 Delirium 88
12 Dementia and Memory Loss 95
13 Involuntary Movements 103
14 Muscle Weakness, Cramps, and Stiffness 110
15 Gait Disorders 122
16 Acute Stroke: The First Hour 132
17 Acute Spinal Cord Syndromes 145
18 Focal Mass Lesions 152
19 Stupor and Coma 168
20 Brain Death 179
• SECTION IV DIAGNOSTIC TESTS 184
21 Computed Tomography 184
22 Magnetic Resonance Imaging 189
23 Positron Emission Tomography and Single-Photon Emission Computed Tomography 203
24 Neurovascular Ultrasound 208
25 Angiography and Neuroendovascular Surgery 217
26 Electroencephalography and Evoked Potentials 230
27 Electromyography, Nerve Conduction Studies, and Magnetic Stimulation 243
28 Autonomic Testing 255
29 Evaluation of the Special Senses (Vision, Hearing, Smell, Vestibular System) 259
30 Sleep Studies 264
31 Neuropsychological Evaluation 271
32 Lumbar Puncture and Cerebrospinal Fluid Analysis 277
33 Brain, Muscle, Nerve, and Skin Biopsy 283
34 Intracranial Pressure and Neurocritical Care Monitoring 288
35 Genetic Testing and DNA Diagnosis 297
• SECTION V CEREBROVASCULAR DISEASES 301
36 Acute Ischemic Stroke 301
37 Transient Ischemic Attack 320
38 Hypoxic-Ischemic Encephalopathy 324
39 Intracerebral Hemorrhage 332
40 Subarachnoid Hemorrhage 342
41 Cerebral Venous and Sinus Thrombosis 353
42 Vascular Malformations 361
43 Central Nervous System Vasculitis 370
44 Posterior Reversible Encephalopathy Syndrome and Other Cerebrovascular Syndromes 384
45 Primary and Secondary Stroke Prevention 401
• SECTION VI NEUROTRAUMA 413
46 Concussion and Chronic Traumatic Encephalopathy 413
47 Traumatic Brain Injury 420
48 Traumatic Spinal Cord Injury 441
49 Traumatic Cranial and Peripheral Nerve Injury 451
• SECTION VII DEMENTIA 469
50 Mild Cognitive Impairment 469
51 Alzheimer Disease 476
52 Frontotemporal Dementia 486
53 Lewy Body Dementias 492
54 Vascular Dementia and Cognitive Impairment 500
55 Prion Diseases 506
• SECTION VIII HEADACHE AND PAIN SYNDROMES 521
56 Primary and Secondary Headache Disorders 521
57 Facial Pain Disorders and Painful Cranial Neuralgias 538
58 Complex Regional Pain Syndrome 549
59 Neuropathic Pain 557
• SECTION IX EPILEPSY AND PAROXYSMAL DISORDERS 567
60 Classi? cation of Seizures and Epilepsy 567
61 Management of Epilepsy 578
62 Ménière Syndrome, Benign Paroxysmal Positional Vertigo, and Vestibular Neuritis 597
63 Transient Global Amnesia 602
• SECTION X CENTRAL NERVOUS SYSTEM INFECTIONS 604
64 Acute Bacterial Meningitis 604
65 Brain, Spinal, and Epidural Abscess and Other Parameningeal Infections 612
66 Other Bacterial Central Nervous System Infections and Toxins 624
67 Chronic Meningitis 640
68 Parasitic Infections 653
69 Viral Infections 661
70 Human Immunode? ciency Virus (HIV) and Acquired Immunode? ciency Syndrome (AIDS) 690
• SECTION XI DEMYELINATING AND INFLAMMATORY DISEASES 711
71 Multiple Sclerosis and Related CNS Neuroimmune Diseases 711
72 Transverse Myelitis 736
73 Neuromyelitis Optica Spectrum Disorder 744
74 Autoimmune Encephalitis and Meningitis 755
75 Neurosarcoidosis 773
• SECTION XII MOVEMENT DISORDERS 778
76 Essential Tremor 778
77 Tics and Tourette Syndrome 784
78 Restless Legs Syndrome 793
79 The Dystonias 800
80 Hemifacial Spasm 820
81 Myoclonus 824
82 Hereditary and Acquired Ataxias 831
83 Tardive Dyskinesia and Other Neuroleptic-Induced Syndromes 849
84 Choreas 854
85 Huntington Disease 861
86 Parkinson Disease 871
87 Parkinson-Plus Syndromes 893
• SECTION XIII NEUROMUSCULAR DISEASES 904
88 Amyotrophic Lateral Sclerosis and Motor Neuron Diseases 904
89 Bell’s Palsy and Cranial Neuropathies 915
90 Mononeuropathies and Compression Neuropathies 927
91 Acquired Peripheral Neuropathies 936
92 Inherited Peripheral Neuropathies 955
93 Myasthenia Gravis and Other Disorders of the Neuromuscular Junction 963
94 In? ammatory and Autoimmune Myopathies 979
95 Critical Illness Myopathy and Neuropathy 989
96 Endocrine and Toxic Myopathies 992
97 Periodic Paralysis and Other Channelopathies 998
98 Stiff Person Syndrome and Peripheral Nerve and Muscle Hyperexcitability 1004
99 Metabolic and Mitochondrial Myopathies in Adults 1011
• SECTION XIV NEUROONCOLOGY 1019
100 Gliomas 1019
101 Metastatic Tumors 1034
102 Meningiomas 1050
103 Primary Central Nervous System Lymphoma 1056
104 Tumors of the Pituitary Gland 1064
105 Pineal Region Tumors 1072
106 Acoustic Neuroma and Other Skull Base Tumors 1080
107 Spinal Tumors 1089
108 Paraneoplastic Syndromes 1100
109 Complications of Cancer Therapy 1106
• SECTION XV HYDROCEPHALUS AND CEREBRAL EDEMA 1114
110 Hydrocephalus 1114
111 Brain Edema and Increased Intracranial Pressure 1127
112 Spontaneous Intracranial Hypotension 1139
• SECTION XVI SPINAL CORD DISORDERS 1145
113 Intervertebral Disk Disease and Radiculopathy 1145
114 Cervical and Lumbar Spinal Stenosis 1153
115 Acquired and Hereditary Myelopathies 1159
• SECTION XVII AUTONOMIC AND SLEEP DISTURBANCES 1170
116 Autonomic Failure, Autonomic Neuropathy, and Orthostatic Intolerance 1170
117 Paroxysmal Sympathetic Hyperactivity After Acute Brain Injury 1178
118 Sleep Disorders 1183
• SECTION XVIII SYSTEMIC ORGAN FUNCTION AND THE NERVOUS SYSTEM 1195
119 Heart-Brain Interactions 1195
120 Sepsis-Associated Encephalopathy 1201
121 Respiratory Support for Neurologic Diseases 1207
122 Endocrine Diseases and the Brain 1215
123 Hematologic Diseases and the Brain 1227
124 Hepatic Disease and the Brain 1245
125 Renal Disease, Electrolyte Disorders, and the Nervous System 1253
126 Gastric and Genitourinary Function and the Brain 1262
127 Bone Diseases and the Central Nervous System 1270
128 Malnutrition, Malabsorption, and Vitamin De? ciencies 1277
129 Neurologic Disease During Pregnancy 1286
130 Neurologic Complications of Organ Transplantation 1298
• SECTION XIX NEUROLOGIC TOXIDROMES 1303
131 Alcoholism 1303
132 Drug Intoxication and Withdrawal 1313
133 Neurotoxicology 1319
134 Radiation Injury 1335
135 Electrical and Lightning Injury 1347
136 Decompression Illness 1350
• SECTION XX PEDIATRIC NEUROLOGY 1355
137 Neonatal Neurology 1355
138 Nervous System Formation and Malformation 1366
139 Inherited Metabolic Diseases 1385
140 Chromosomal Disorders and Disorders of DNA 1410
141 The Floppy Infant 1417
142 Disorders of Motor and Cognitive Development 1424
143 Autism Spectrum Disorders 1433
144 Mitochondrial Encephalomyopathies 1441
145 Neurocutaneous Syndromes 1456
146 Spinal Muscular Atrophies of Childhood 1467
147 Muscular Dystrophies and Congenital Myopathies 1474
148 Seizures and Epilepsies in Neonates and Children 1502
149 Pediatric Stroke 1515
150 Brain Tumors in Children 1528
151 Pediatric Brain Injury and Shaken Baby Syndrome 1572
152 Human Immunode? ciency Virus, Fetal Alcohol Syndrome, and Drug Effects 1579
• SECTION XXI PSYCHIATRY AND NEUROLOGY 1588
153 Psychosis 1588
154 Mood Disorders 1596
155 Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder 1606
156 Somatic Symptom Disorders 1615
• SECTION XXII RECOVERY AND END-OF-LIFE CARE 1629
157 Neurologic Rehabilitation 1629
158 End-of-Life and Palliative Care in Neurology 1636
Index 1645

For more than 60 years, Merritt’s Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today’s practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.

• Contains more than 150 succinct chapters that offer essential information on signs and symptoms, diagnostic tests, and neurologic disorders of all etiologies.
• Includes a new section on the global burden of neurological disease, coverage of neurological implications of COVID-19, and new chapters covering:
• Addiction
• Sepsis associated encephalopathy
• New treatment modalities of previously incurable disorders, including inherited neuromuscular diseases
• New treatments with improved efficacy and tolerability in acute stroke and multiple sclerosis, among others
• Incorporation of new emerging and established biomarkers into practice
• Helps you quickly navigate the text and easily visualize neurologic topics with a vivid, highly illustrated, full-color format throughout. Many figures and tables have been incorporated throughout the text for quick reference.
• Electronic versions of the book will feature a series of new “Need to Know Neurology” video clips that focus on key take-home messages.
• The textbook can also be bundled with Merritt’s Neurology Board Review, a forthcoming companion book with over 500 sample board review questions and answers.

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