MICRONEEDLING IN CLINICAL PRACTICE

1. Microneedles and Trandermal Transport
2. Skin perforation and solid microneedles
3. Dissolvable and Coated Microneedle Arrays: Design, Fabrication, Materials, and Administration Methods
4. Hollow Microneedles
5. Microneedles vs other transdermal technologies
6. Combination of Microneedles with other methods
7. Medical Applications of Microneedles
8. Therapeutic drug and biomolecule monitoring potential for microneedle technologies
9. Commercialized Microneedles
10. Considerations for Clinical Trials Involving Microneedle Devices
11. Cosmetic Applications
12. Dermatotoxicology of Microneedles in Man
Index

Microneedles provide an artificial pathway across the skin barrier for medical and cosmetic applications. This technology has seen a significant increase in popularity over the past years; as an example, the use of multiple small needles mounted on a roller to pierce the skin, prompting it to stimulate collagen production, has undergone a resurgence of interest as an adjunctive procedure for a number of skin disorders. This monograph draws together what is known about how to integrate microneedle technology into clinical dermatologic practice.

Authors
• Boris Stoeber, PEng, PhD is Professor, Mechanical Engineering and Electrical and Computer Engineering, Research Chair in Microfluidics and Sensing Technology, Faculty of Applied Science, University of British Columbia, Vancouver
• Raja K Sivamani, MD, MS (Bioengineering), AP is Ayurvedic Practitioner, Pacific Skin Institute; Adjunct Associate Professor of Clinical Dermatology, Director of Clinical Research, University of California, Davis; Associate Professor of Dermatology, California Northstate University, College of Medicine; and Adjunct Assistant Professor, Co-Director of Microbiome Labs Research Initiative, Department of Biological Sciences, California State University, Sacramento
• Howard I. Maibach, MD is Professor, Dermatology, School of Medicine, University of California at San Francisco