MOLECULAR BIOLOGY OF LONG NON-CODING RNAS

Preface
Chromatin regulation by long non-coding RNAs
Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs
Roles of long non-coding RNAs in X-chromosome inactivation
Roles of Long Non-Coding RNAs in Genomic Imprinting
Dysregulation of long noncoding RNAs in human disease
Functions of long non-coding RNAs in non-mammalian systems
Emerging technologies to study long non-coding RNAs
Long non coding RNAs and nuclear body formation and function
The role of long non-coding RNAs in immunity
Novel methods to study long non-coding RNAs
OMICs of long non-coding RNAs
Cancer epigenetics and long non-coding RNAs
Roles of long non-coding RNAs in human development
Index

This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Features
• Focuses on the recently discovered, and less understood, class of long non-coding RNAs
• Discusses new concepts and novel approaches to studying lncRNAs
• Additional expert authors in the field covering novel technologies