MOLECULAR PATHOLOGY. A PRACTICAL GUIDE FOR THE SURGICAL PATHOLOGIST AND CYTOPATHOLOGIST

This practical manual provides a comprehensive yet concise guide to state-of-the-art molecular techniques and their applications. It starts with an overview of the essential principles of molecular techniques, followed by separate chapters detailing the use of these techniques in particular tissues and organs, and describing recommended treatment plans. Each chapter covers the tests available, their advantages, limitations, and use as diagnostic and prognostic tools, with key learning points at the end of each topic. Using both histologic and cytologic samples, it discusses how to interpret test results in a pathologic context and enables trainees and practising pathologists to gain an in-depth understanding of molecular diagnostic techniques and how to incorporate them into routine diagnostic practice. Aiding the daily practice of refining diagnosis, as well as offering a didactic approach, this book is an essential reference for practising pathologists and cytopathologists as well as trainees in pathology.

- Offers a system-specific molecular approach in tissues and cytological preparations and covers current and future trends in molecular pathology to familiarize pathologists and cytopathologists with molecular diagnostic and prognostic criteria.
- Describes the application of molecular techniques in diagnostic histopathology, cytopathology and clinical management.
- Each chapter ends with a set of key learning points, offering a summary as well as a learning tool to surgical pathologists and cytopathologists.

Authors
- John M. S. Bartlett, PhD, FRCPath, is Director of Transformative Pathology and Improved Management of Early Cancer at the Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
- Abeer Shaaban is Consultant Pathologist at the Department of Cellular Pathology, Queen Elizabeth Hospital, Birmingham, UK, and Lecturer at the Department of Pathology, Tanta University Hospital, Tanta, Egypt.
- Fernando Schmitt is Director of the Department of Medicine and Pathology at the Laboratoire National de Sante, Dudelange, Luxembourg.

Table of Contents
1. An introduction to molecular pathology
2. Molecular regulation of cellular function
3. Practical application of molecular techniques in diagnostic histopathology and cytopathology and clinical management
4. Fluorescent and non-fluorescent in situ hybridization
5. Clinical applications of the polymerase chain reaction for molecular pathology
6. Are microarrays ready for prime time
7. Tissue microarrays
8. Sequencing
9. Microsatellite instability in colorectal cancer
10. Mutational analysis
11. Tumors of the breast
12. Tumors of the female genital system
13. Tumours of the male urogenital system
14. Tumors of the gastrointestinal system
15. Soft tissue, bone and skin tumours
16. Cardio-thoracic tumors
17. Tumors of the endocrine system
18. Haematological malignancies of the lymph nodes
19. Pediatric tumors
20. Serous effusions
21. Academic applications and future of molecular pathology
Index.