MOLECULAR RADIO-ONCOLOGY

1. DNA Repair
2. Cancer Stem Cells
3. Molecular Targeting of Growth Factor Receptor Signaling in Radiation Oncology
4. Molecular Targeting of Integrins and Integrin-Associated Signaling Networks in Radiation Oncology
5. Personalized Radiation Oncology: Epidermal Growth Factor Receptor and Other Receptor Tyrosine Kinase Inhibitors
6. Hypoxia as a Biomarker and for Personalized Radiation Oncology
7. Human Papilloma Virus as a Biomarker for Personalized Head and Neck Cancer Radiotherapy
8. FDG and Beyond
9. On the Reliability of Automatic Volume Delineation in Low-Contrast
10. FMISO as a Biomarker for Clinical Radiation Oncology

This book concisely reviews our current understanding of hypoxia, molecular targeting, DNA repair, cancer stem cells, and tumor pathophysiology, while also discussing novel strategies for putting these findings into practice in daily clinical routine. Radiotherapy is an important part of modern multimodal cancer treatment, and the past several years have witnessed not only substantial improvements in radiation techniques and the use of new beam qualities, but also major strides in our understanding of molecular tumor biology and tumor radiation response. Against this backdrop, the book highlights recent efforts to identify reasonable and clinically applicable biomarkers using broad-spectrum tissue microarrays and high-throughput systems biology approaches like genomics and epigenomics. In particular, it describes in detail how such molecular information is now being exploited for diagnostic imaging and imaging throughout treatment using the example of positron emission tomography. By discussing all these issues in the context of modern radiation oncology, the book provides a broad, up-to-date overview of the molecular aspects of radiation oncology that will hopefully foster its further optimization.

Features
• Reviews our current understanding of the most important aspects of molecular radiobiology
• Discusses recent efforts to identify reasonable and clinically applicable biomarkers
• Describes how molecular information is being exploited for diagnostic imaging and imaging throughout treatment

Authors
• Michael Baumann, University of Technology, Dresden, Germany.
• Mechthild Krause, University of Technology, Dresden, Germany.
• Nils Cordes, University of Technology, Dresden, Germany.