MULTIPLE SCLEROSIS AND RELATED DISORDERS. CLINICAL GUIDE TO DIAGNOSIS, MEDICAL MANAGEMENT, AND REHABILITATION

1. The History of Multiple Sclerosis
2. Overview of Multiple Sclerosis
3. Pathology and Pathophysiology of Multiple Sclerosis
4. Epidemiology and Natural History of Multiple Sclerosis
5. Multiple Sclerosis Genetics
6. Symptoms and Signs of Multiple Sclerosis
7. Diagnosis of Multiple Sclerosis
8. MRI in Multiple Sclerosis
9. Tools and Tests in Multiple Sclerosis
10. Differential Diagnosis of Multiple Sclerosis
11. Overview of Present Treatment for Relapsing Forms of Multiple Sclerosis
12. Relapse Management in Multiple Sclerosis
13. Disease Modifying Therapies in Relapsing Multiple Sclerosis
14. Primary Progressive Multiple Sclerosis
15. Secondary Progressive Multiple Sclerosis
16. Emerging Therapies for Multiple Sclerosis
17. Overview of Rehabilitation and Symptom Management in Multiple Sclerosis
18. Fatigue in Multiple Sclerosis
19. Emotional Disorders in Multiple Sclerosis
20. Cognitive Disorders in Multiple Sclerosis
21. Epilepsy, Sleep Disorders, and Transient Neurological Events in Multiple Sclerosis
22. Eye Symptoms, Signs, and Therapy in Multiple Sclerosis
23. Bulbar and Pseudo-Bulbar Dysfunction in Multiple Sclerosis
24. Pain/Dysesthesia Management in Multiple Sclerosis
25. Bladder and Bowel Dysfunction in Multiple Sclerosis
26. Sexual and Other Autonomic Dysfunction
27. Spasticity Management in Multiple Sclerosis
28. Multiple Sclerosis and Ambulation
29. Health and Wellness in Multiple Sclerosis
30. Complementary and Alternative Medicine in Multiple Sclerosis
31. Pediatric Multiple Sclerosis
32. Women""s Issues
33. Multiple Sclerosis in Older Age Groups
34. Societal Issues in Multiple Sclerosis
35. Comprehensive Care in Multiple Sclerosis
36. Caregiving in Multiple Sclerosis
37. Neuromyelitis Optica
38. Acute Disseminated Ecephalomyelitis

Multiple Sclerosis and Related Disorders addresses recent developments in the neuroimmunological field to provide the practical approaches a health care practitioner needs to know in the evaluation and long-term care of MS patients. Information on disease history, pathophysiology, and biology is included to provide clinicians with a framework for understanding current diagnosis, monitoring, and treatment strategies for these disorders. In addition to reviewing disease-modifying treatments, the authors have devoted significant focus to the symptoms that frequently manifest and their treatment options. Symptoms and functional limitations are the "face of the disease" for patients and present their own set of challenges.

The book proceeds through diagnosis (initial symptoms, criteria and classification, imaging, lab tests, and differential diagnosis), approved treatments for the various MS types (including emerging therapies where appropriate), symptom management, rehabilitative issues, general health and wellness, and an overview of MS clinical trials. Special attention is given to special populations, societal and family issues, CCSVI, and related disorders that are often mistaken for MS. Dedicated chapters on Neuromyelitis optica and acute disseminated encephalomyelitis incorporate newer diagnostic criteria. Because comorbidities often make the management of MS-related disability more complex, the book addresses these comorbidities as part of a comprehensive management plan.

To enhance the clinical utility, critical-to-know information and management pearls are boxed for quick reference. Illustrations, tables, graphs, assessment scales, and up-to-date MRI imaging inform the text throughout. Where appropriate, chapters include illustrative cases, "Key Points" for clinicians, and "Key Points" for patients and families. The treatment chapters include specific recommendations where available (AAN guidelines, Cochrane; including levels of evidence to support recommendations) and highlight areas of controversy. Selected chapters will also feature a section on the "Cleveland Clinic approach" to go beyond the literature and provide real-world guidance for practitioners.

Multiple Sclerosis and Related Disorders Features:
• Comprehensive clinical reference for all members of the MS care team
• Focus on practical approaches to diagnosis, treatment, counselling, and rehabilitative strategies
• Extensive chapters on symptom management and women's issues in MS
• Edited and written primarily by expert clinicians at Cleveland Clinic/Mellen Center
• Evidence- and experience-based guidance
• Dedicated chapters on Neuromyelitis optica and acute disseminated encephalomyelitis incorporating newer diagnostic criteria
• Includes treatment guidelines and numerous illustrations, tables, scales; key information is highlighted for quick reference

Authors
• Alexander Rae-Grant, MD, FRCP(C), is Staff Neurologist and Director of Multiple Sclerosis Education; Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH.
• Robert J. Fox, MS, FAAN, MD, Medical Director; Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH.