MUSCULOSKELETAL PAIN

Musculoskeletal Pain: Basic Mechanisms and Implications presents state-of-the-art research into the peripheral and central neurobiological mechanisms in musculoskeletal pain. Presented in three main sections, this publication will update the reader on the clinical perspectives in musculoskeletal conditions; muscle, joint, bone, and fascia nociception; and translational musculoskeletal pain and quantitative models.

Authors
- Thomas Graven-Nielsen, DMSc, PhD, M Sc EE, is a full professor in human pain neuroscience at the Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark. Since 2006, he has been head of the International Doctoral School in Medicine, Biomedical Science, and Technology at Aalborg University. He is also chair of IASP’s Special Interest Group on Musculoskeletal Pain. He has published substantially within the musculoskeletal pain field, focusing on pain models, biomarkers, and assessment technologies to study muscle and joint pain, referred pain, deep-tissue hyperalgesia, and muscle function during musculoskeletal pain.
- Lars Arendt-Nielsen, DMSc, PhD, is full professor in translational pain research, founder, and director of the International Center for Sensory-Motor Interaction (SMI), Aalborg University, Denmark. He is also the founder and director of R&D at the clinical trial unit, C4Pain. He has delivered more than 200 keynote lectures at international conferences and has published more than 840 peer-reviewed journal papers on experimental and clinical assessment of pain and on application of human pain biomarkers in drug development. Has served on the IASP Council, as co-chair of the IASP Global Year Against Musculoskeletal Pain in 2010, and is on the board of IASP Press. He is chair-elect of IASP’s Special Interest Group on Musculoskeletal Pain. In 2007, he was knighted by the Danish Queen for his contribution to science.

Contents
Part I: Clinical Perspectives in Musculoskeletal
Conditions
1: Myofascial Pain Syndrome
2: The Relation Between Structural Joint Pathology and Joint Pain
3: Tendinopathy Pain
4: Low Back Pain Characteristics and Changes in Lumbar Muscle Structure
5: Neck Pain: Some Clinical and Epidemiological Aspects Concerning Nonspecific Neck Pain
6: Whiplash Injury Pain
7: Shoulder Pain
8: Referred Muscular Hyperalgesia in Visceral Pain Conditions
9: Deep Tissue Hyperalgesia in Persistent Postsurgical Pain
10: Mechanisms of Pain in Osteoarthritis and Rheumatoid Arthritis
Part II: Musculoskeletal Nociception: Basic Findings
11: Physiological Properties of Muscle Nociceptors
12: Peripheral Fascial Nociceptors and Their Spinal Projections
13: Receptors Relevant for Joint Nociception
14: Bone-Related Nociception
15: Facilitated Mechanical Response of Muscle Nociceptors After Exercise: Involvement of Neurotrophic Factors
16: Modulation of Muscle Spindle Activity by Muscle Pain
17: Incision-Induced Nociceptive Effects in Deep Tissue
18: Mechanisms of Nociception in Models of Osteoarthritic Pain
19: Sex-Related Differences in Muscle Nociceptor Properties
20: Sensitization of Muscle Nociceptors and Central Sensitization Resulting from Nociceptive Input from Muscle
21: Widespread Chronic Pain: Underlying Mechanisms and Clinical Implications
22: Glial Cells in Musculoskeletal Pain
Part III: Translational Musculoskeletal Pain and Quantitative Models
23: Assessment of Musculoskeletal Pain Mechanisms and Relevant Human Experimental Models
24: Peripheral Algesic Substances in Musculoskeletal Pain Assessed by Microdialysis
25: Mechanisms Underlying Extraterritorial and Widespread Sensitization: From Animal to Chronic Pain
26: Reorganized Motor Control at Cortical, Subcortical, and Spinal Levels in Neck and Low Back Pain
27: Sex-Related Differences in Clinical and Experimental Muscle Pain 457 buy
28: The Hypoalgesic Effects of Exercise: Characteristics, Mechanisms, and Implications for Chronic Pain
29: Central Processing of Acute and Chronic Musculoskeletal Pain: Brain Imaging Studies
30: Predicting Development of Chronic Musculoskeletal Pain: Contrasting the Brain Imaging Viewpoint with Classical Models