2. Biological Events and Barriers to Effective Delivery of Cancer Therapeutics
3. Cancer Diagnostics and Therapeutics
4. Nanomedicine in Cancer
5. Theranostics: A Historical Perspective of Cancer Nanotechnology Paving the Way for Simultaneous Use Applications
6. In Vitro Cancer Diagnostics
7. Translational Nanodiagnostics for In Vivo Cancer Detection
8. Delivery of Cancer Nanotherapeutics
9. Oral Nanotherapeutics for Cancer with Innovations in Lipid and Polymeric Nanoformulations
10. Topical and Transdermal Nanomedicines for Cancer Therapy
11. Cancer Nanotherapeutics Administered by Non-conventional Routes
12. Regulatory Considerations for Cancer Drug Products Containing Nanomaterials
13. Perspectives for Characterizing Drug Component of Theranostic Products Containing Nanomaterials
14. Engineering Multifunctional Nanomedicine Platforms for Drug Delivery and Imaging
15. Image-Guided Drug Delivery
16. Nanotheranostics-Based Imaging for Cancer Treatment Monitoring
17. Remotely Triggered Nanotheranostics
18. Concluding Remarks and the Future of Nanotheranostics
This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field.
Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area.
This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.
• Provides a comprehensive review of cancer nanotheranostics
• Represents the first book-length treatment of the topic
• Presents a full picture of the field, from basic research through clinical implementation
• Features evidence-based chapters with excellent illustrations and images to guide and assist the reader