NEGLECTED TROPICAL DISEASES: DRUG DISCOVERY AND DEVELOPMENT

1 Drug Discovery Strategies for Neglected Tropical Diseases: Repurposing Knowledge, Mechanisms and Therapeutics to Increase Discovery Efficiency 1
• Part I Virus 15
2 Toward Antiviral Therapies for the Treatment of Zika Virus Infection: Lessons Learned from Dengue Virus 17
3 Developing Therapeutics for Ebola Virus Disease: A Multifaceted Approach 49
• Part II Kinetoplastids 93
4 Designing Drugs to Target Trypanosoma cruzi, the Etiological Agent of Chagas Disease: When Chemistry needs Biology 95
5 Drug Discovery and Development for Human African Trypanosomiasis 115
6 Discovery of Drugs for Leishmaniases: A Progress Report 139
• Part III Helminths 161
7 Onchocerciasis Drug Discovery 163
8 Drug Discovery and Development for Schistosomiasis 187
9 Soil-transmitted Helminthiasis – Challenges with Discovery of Novel Anthelmintics 227
10 Drug Discovery and Development for the Treatment of Echinococcosis, Caused by the Tapeworms Echinococcus granulosus and Echinococcus multilocularis 253
11 New Insights into the Treatment of Foodborne Trematode Infections 289
• Part IV Bacteria 325
12 Buruli Ulcer 327
13 Drug Discovery and Development for Leprosy 349

A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people.

Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation.

The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book:

-Ties together information from different sources for developing novel treatsments forneglected tropical diseases
-Is aligned with WHO?s initiative to eradicate tropical diseases
-Outlines current and potential drugs for treating tropical diseases
-Provides a standard reference for the entire field

Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Authors
• David Swinney, PhD, is the chief executive officer of the Institute for Rare and Neglected Diseases Drug Discovery (iRND3). Dr. Swinney has devoted the majority of his career to analyzing and implementing drug discovery strategies that will increase the chance of success.
• Michael Pollastri holds the chair of chemistry and chemical biology at Northeastern University in Boston. He came to NEU from Pfizer, where he worked for 10 years as a research chemist. His research focus is discovery of new therapeutics for neglected tropical diseases.