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Volume 1
• Part I the Field of Pediatrics
1 Overview of Pediatrics
2 Child Health Disparities
3 Global Child Health
4 Quality and Value in Healthcare for Children
5 Safety in Healthcare for Children
6 Ethics in Pediatric Care
7 Complementary Therapies and Integrative Medicine
8 Pediatric Palliative Care
9 Domestic and International Adoption
10 Foster and Kinship Care
11 Medical Evaluation of the Foreign-born Child
12 Cultural Issues in Pediatric Care
13 Maximizing Children’s Health: Screening, Anticipatory Guidance, and Counseling
14 Injury Control
15 Impact of Violence Exposure on Children
16 Child Trafficking for Sex and Labor
17 Abused and Neglected Children
18 Strategies for Health Behavior Change
• Part II Growth, Development, and Behavior
19 Developmental and Behavioral Theories
20 Positive Parenting and Support
21 Assessment of Fetal Growth and Development
22 the Newborn
23 the First Year
24 the Second Year
25 the Preschool Years
26 Middle Childhood
27 Assessment of Growth
28 Developmental and Behavioral Surveillance and Screening
29 Child Care
30 Loss, Separation, and Bereavement
31 Sleep Medicine
• Part III Behavioral and Psychiatric Disorders
32 Psychosocial Assessment and Psychiatric Diagnostic Evaluation
33 Psychopharmacology
34 Psychotherapy
35 Somatic Symptom and Related Disorders
36 Rumination and Pica
37 Motor Disorders and Habits
38 Anxiety Disorders, Obsessive-compulsive Disorder, and Posttraumatic Stress Disorder
39 Mood Disorders
40 Suicide and Attempted Suicide
41 Eating Disorders
42 Disruptive, Impulse-control, and Conduct Disorders
43 Tantrums and Breath-holding Spells
44 Lying, Stealing, and Truancy
45 Aggression
46 Self-injurious Behavior
47 Childhood Psychoses
48 Delirium
• Part IV Learning and Developmental Disorders
49 Neurodevelopmental and Executive Function and Dysfunction
50 Attention-deficit/hyperactivity Disorder
51 Dyslexia
52 Math and Writing Disabilities
53 Language Development and Communication Disorders
54 Augmentative and Alternative Communication
55 Outcomes Among Infants and Children Who Are Deaf/hard of Hearing
56 Developmental Delay and Intellectual Disability
57 Down Syndrome and Other Abnormalities of Chromosome Number
58 Autism Spectrum Disorder
59 Fragile X Syndromes
• Part V Nutrition
60 Nutritional Requirements
61 Feeding Healthy Infants, Children, and Adolescents
62 Nutrition, Food Security, and Health
63 Refeeding Syndrome
64 Malnutrition in High-resource Settings
65 Overweight and Obesity
66 Vitamin a Deficiencies and Excess
67 Vitamin B Complex Deficiencies and Excess
68 Vitamin C (Ascorbic Acid) Deficiency and Excess
69 Vitamin D Deficiency (Rickets) and Excess
70 Vitamin E Deficiency
71 Vitamin K Deficiency
72 Micronutrient Mineral Deficiencies
• Part VI Fluid and Electrolyte Disorders
73 Electrolyte and Acid-base Disorders
74 Maintenance and Replacement Therapy
75 Deficit Therapy
76 Fluid and Electrolyte Treatment of Specific Disorders
• Part VII Emergency Medicine, Critical Care, and Anesthesia
77 Emergency Medical Services for Children
78 Triage of the Acutely Ill Child
79 Pediatric Cardiorespiratory Emergencies and Resuscitation
80 Acute Care of Multiple Trauma
81 Spinal Cord Injuries in Children
82 Neurologic Emergencies and Stabilization
83 Brain Death: Death by Neurologic Criteria
84 Syncope
85 Shock
86 Acute Care of Respiratory Distress and Failure
87 Altitude-associated Illness in Children
88 Drowning and Submersion Injury
89 Burn Injuries
90 Cold Injuries
91 Anesthesia and Perioperative Care
92 Procedural Sedation
93 Pediatric Pain Management
94 Poisoning
• Part VIII Human Genetics
95 Genetics in Pediatric Medicine
96 Principles of Human Genetics
97 Patterns of Genetic Transmission
98 Integration of Genetics Into Pediatric Practice
99 Chromosome Disorders
100 Dysmorphology, Phenotyping, and Sequences
101 Signaling Pathway Disorders
102 Chromatin Regulatory Disorders
103 Genetics of Common Disorders
• Part IX Metabolic Disorders
104 an Approach to Inborn Errors of Metabolism
105 Defects in Metabolism of Amino Acids
106 Defects in Metabolism of Lipids
107 Defects in Metabolism of Carbohydrates
108 Mitochondrial Disease Diagnosis
109 Mucopolysaccharidoses
110 Disorders of Purine and Pyrimidine Metabolism
111 Hutchinson-gilford Progeria Syndrome (Progeria)
112 the Porphyrias
113 Hypoglycemia
• Part X the Fetus and the Neonatal Infant
114 Overview of Morbidity and Mortality
115 the Newborn Infant
116 High-risk Pregnancies
117 the Fetus
118 Fetal Intervention and Surgery
119 the High-risk Infant
120 Transport of the Critically Ill Newborn
121 Clinical Manifestations of Diseases in the Newborn Period
122 Nervous System Disorders
123 Neonatal Resuscitation and Delivery Room Emergencies
124 Transition to Newborn Pulmonary Respiration
125 Apnea
126 Respiratory Distress Syndrome (Hyaline Membrane Disease)
127 Bronchopulmonary Dysplasia
128 Transient Tachypnea of the Newborn
129 Aspiration of Foreign Material (Meconium Aspiration Syndrome, Aspiration Pneumonia)
130 Persistent Pulmonary Hypertension of the Newborn (Persistent Fetal Circulation)
131 Diaphragmatic Hernia
132 Pulmonary Air Leaks: Pneumothorax, Pneumomediastinum, Pulmonary Interstitial Emphysema, Pneumopericardium
133 Pulmonary Hemorrhage
134 Digestive System Disorders
135 Meconium Ileus, Peritonitis, Intestinal Obstruction, and Gastroschisis
136 Necrotizing Enterocolitis
137 Jaundice and Hyperbilirubinemia in the Newborn
138 Blood Disorders
139 Anemia in the Newborn Infant
140 Hemolytic Disease of the Fetus and Newborn
141 Neonatal Polycythemia
142 Hemorrhage in the Newborn Infant
143 Nonimmune Hydrops
144 the Umbilicus
145 Neonatal Abstinence Syndrome
146 Fetal Alcohol Spectrum Disorder
147 Infants of Diabetic Mothers
148 Epidemiology of Infections
149 Congenital and Perinatal Infections
• Part XI Adolescent Medicine
150 Adolescent Physical and Social Development
151 Delivery of Healthcare to Adolescents
152 Transitioning to Adult Care
153 Gender Identity and Transgender Care
154 Gay, Lesbian, and Bisexual Adolescents
155 the Epidemiology of Adolescent Health Problems
156 Violent Behavior
157 Substance Use Disorder
158 the Breast
159 Menstruation-related Disorders
160 Contraception
161 Adolescent Pregnancy
162 Adolescent Sexual Assault
163 Sexually Transmitted Infections
• Part XII Immunology
Section 1 Evaluation of the Immune System
164 Orientation to the Consideration of Inborn Errors of Immunity
Section 2 the T-, B-, and Nk-cell Systems
165 T-cell and Combined Deficiencies
166 B-cell and Antibody Deficiencies
167 Natural Killer Cells
Section 3 the Phagocytic System
168 Neutrophils
169 Eosinophils
170 Disorders of Phagocyte Function
171 Leukopenia
172 Leukocytosis
Section 4 Complement System
173 Complement System
Section 5 Immune Dysregulation
174 Immune Dysregulation
175 Defects of Innate Immunity
176 Approaches to Treatment of Primary Immune Deficiency Diseases
Section 6 Hematopoietic Stem Cell Transplantation
177 Principles and Clinical Indications of Hematopoietic Stem Cell Transplantation
178 Hematopoietic Stem Cell Transplantation From Alternative Sources and Donors
179 Graft-versus-host Disease, Rejection, and Venoocclusive Disease
180 Infectious Complications of Hematopoietic Stem Cell Transplantation
181 Late Effects of Hematopoietic Stem Cell Transplantation
• Part XIII Allergic Disorders
182 Allergy and the Immunologic Basis of Atopic Disease
183 Diagnosis of Allergic Disease
184 Allergic Rhinitis
185 Childhood Asthma
186 Atopic Dermatitis (Atopic Eczema)
187 Insect Allergy
188 Ocular Allergies
189 Urticaria (Hives) and Angioedema
190 Anaphylaxis
191 Serum Sickness
192 Food Allergy and Adverse Reactions to Foods
193 Adverse and Allergic Reactions to Drugs
• Part XIV Rheumatic Diseases of Childhood (Connective Tissue Disease, Collagen Vascular Diseases)
194 Evaluation of Suspected Rheumatic Disease
195 Treatment of Rheumatic Diseases
196 Juvenile Idiopathic Arthritis
197 Ankylosing Spondylitis and Other Spondyloarthritides
198 Reactive and Postinfectious Arthritis
199 Systemic Lupus Erythematosus
200 Juvenile Dermatomyositis
201 Scleroderma and Raynaud Phenomenon
202 Behçet Disease
203 Sjögren Syndrome
204 Hereditary Periodic Fever Syndromes and Other Systemic Autoinflammatory Diseases
205 Interferonopathies
206 Amyloidosis
207 Macrophage Activation Syndrome
208 Kawasaki Disease
209 Sarcoidosis
210 Vasculitis Syndromes
211 Musculoskeletal Pain Syndromes
212 Chronic Overlapping Pain Conditions
213 Miscellaneous Conditions Associated With Arthritis
• Part XV Infectious Diseases
Section 1 General Considerations
214 Public Health Approach to Pandemics
Section 2 Preventive Measures
215 Immunization Practices
216 Infection Prevention and Control
217 Childcare and Communicable Diseases
218 Health Advice for Children Traveling Internationally
219 Fever
220 Fever Without a Focus in the Neonate and Young Infant
221 Fever in the Older Child
222 Fever of Unknown Origin
223 Infections in Immunocompromised Persons
224 Infection Associated With Medical Devices
Section 3 Antibiotic Therapy
225 Principles of Antibacterial Therapy
226 Antimicrobial Stewardship
Section 4 Gram-positive Bacterial Infections
227 Staphylococcus
228 Streptococcus Pneumoniae (Pneumococcus)
229 Group a Streptococcus
230 Group B Streptococcus
231 Non–group a or B Streptococci
232 Enterococcus
233 Diphtheria (Corynebacterium Diphtheriae)
234 Listeria Monocytogenes
235 Actinomyces
236 Nocardia
Section 5 Gram-negative Bacterial Infections
237 Neisseria Meningitidis (Meningococcus)
238 Neisseria Gonorrhoeae (Gonococcus)
239 Kingella Kingae
240 Haemophilus Influenzae
241 Chancroid (Haemophilus Ducreyi)
242 Moraxella Catarrhalis
243 Pertussis (Bordetella Pertussis and Bordetella Parapertussis)
244 Salmonella
245 Shigella
246 Escherichia Coli
247 Cholera
248 Campylobacter
249 Yersinia
250 Aeromonas and Plesiomonas
251 Pseudomonas, Burkholderia, and Stenotrophomonas
252 Tularemia (Francisella Tularensis)
253 Brucella
254 Legionella
255 Bartonella
Section 6 Anaerobic Bacterial Infections
256 Botulism (Clostridium Botulinum)
257 Tetanus (Clostridium Tetani)
258 Clostridioides Difficile Infection
259 Other Anaerobic Infections
Section 7 Mycobacterial Infections
260 Principles of Antimycobacterial Therapy
261 Tuberculosis (Mycobacterium Tuberculosis)
262 Hansen Disease (Mycobacterium Leprae)
263 Nontuberculous Mycobacteria
Section 8 Spirochetal Infections
264 Syphilis (Treponema Pallidum)
265 Nonvenereal Treponemal Infections
266 Leptospira
267 Relapsing Fever (Borrelia)
268 Lyme Disease (Borrelia Burgdorferi)
Section 9 Mycoplasmal Infections
269 Mycoplasma Pneumoniae
270 Genital Mycoplasmas (Mycoplasma Hominis, Mycoplasma Genitalium, and Ureaplasma Urealyticum)
Section 10 Chlamydial Infections
271 Chlamydia Pneumoniae
272 Chlamydia Trachomatis
273 Psittacosis (Chlamydia Psittaci)
Section 11 Rickettsial Infections
274 Spotted Fever Group Rickettsioses
275 Scrub Typhus (Orientia Tsutsugamushi)
276 Typhus Group Rickettsioses
277 Ehrlichiosis and Anaplasmosis
278 Q Fever (Coxiella Burnetii)
Section 12 Fungal Infections
279 Principles of Antifungal Therapy
280 Candida
281 Cryptococcus Neoformans and Cryptococcus Gattii
282 Malassezia
283 Aspergillus
284 Histoplasmosis (Histoplasma Capsulatum)
285 Blastomycosis
286 Coccidioidomycosis (Coccidioides Species)
287 Paracoccidioides Brasiliensis
288 Sporotrichosis (Sporothrix Schenckii)
289 Mucormycosis
290 Pneumocystis Jirovecii
291 Other Pathogenic Fungi
Section 13 Viral Infections
292 Principles of Antiviral Therapy
293 Measles
294 Rubella
295 Mumps
296 Polioviruses
297 Nonpolio Enteroviruses
298 Parvoviruses
299 Herpes Simplex Virus
300 Varicella-zoster Virus
301 Epstein-barr Virus
302 Cytomegalovirus
303 Roseola (Human Herpesviruses 6 and 7)
304 Human Herpesvirus 8
305 Influenza Viruses
306 Parainfluenza Viruses
307 Respiratory Syncytial Virus
308 Human Metapneumovirus
309 Adenoviruses
310 Rhinoviruses
311 Coronaviruse
312 Rotaviruses, Caliciviruses, and Astroviruses
313 Human Papillomaviruses
314 Arboviral Infections
315 Dengue Fever, Dengue Hemorrhagic Fever, and Severe Dengue
316 Yellow Fever
317 Ebola and Other Viral Hemorrhagic Fevers
318 Lymphocytic Choriomeningitis Virus
319 Hantavirus Pulmonary Syndrome
320 Rabies
321 Polyomaviruses
322 Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
323 Human T-cell Leukemia Viruses (1 and 2)
324 Transmissible Spongiform Encephalopathies
Section 14 Antiparasitic Therapy
325 Principles of Antiparasitic Therapy
Section 15 Protozoan Diseases
326 Primary Amebic Meningoencephalitis
327 Amebiasis
328 Giardiasis and Balantidiasis
329 Cryptosporidium, Cystoisospora, Cyclospora, and Microsporidia
330 Trichomoniasis (Trichomonas Vaginalis)
331 Leishmaniasis (Leishmania)
332 African Trypanosomiasis (Sleeping Sickness; Trypanosoma Brucei Complex)
333 American Trypanosomiasis (Chagas Isease; Trypanosoma Cruzi)
334 Malaria (Plasmodium)
335 Babesiosis (Babesia)
336 Toxoplasmosis (Toxoplasma Gondii)
Section 16 Helminthic Diseases
337 Ascariasis (Ascaris Lumbricoides)
338 Hookworms (Necator Americanus and Ancylostoma Spp.)
339 Trichuriasis (Trichuris Trichiura)
340 Enterobiasis (Enterobius Vermicularis)
341 Strongyloidiasis (Strongyloides Stercoralis)
342 Lymphatic Filariasis (Brugia Malayi, Brugia Timori, and Wuchereria Bancrofti)
343 Other Tissue Nematodes
344 Toxocariasis (Visceral and Ocular Larva Migrans)
345 Trichinellosis (Trichinella Spiralis)
346 Schistosomiasis (Schistosoma)
347 Flukes (Liver, Lung, and Intestinal)
348 Adult Tapeworm Infections
349 Cysticercosis
350 Echinococcosis (Echinococcus Granulosus Sensu Lato and Echinococcus Multilocularis)

Volume 2
• Part XVI The Digestive System
Section 1 Clinical Manifestations of Gastrointestinal Disease
351 Normal Digestive Tract Phenomena
352 Major Symptoms and Signs of Digestive Tract Disorders
Section 2 the Oral Cavity
353 Development and Developmental Anomalies of the Teeth
354 Disorders of the Oral Cavity Associated With Other Conditions
355 Malocclusion
356 Cleft Lip and Palate
357 Syndromes With Oral Manifestations
358 Dental Caries
359 Periodontal Diseases
360 Dental Trauma
361 Common Lesions of the Oral Soft Tissues
362 Diseases of the Salivary Glands and Jaws
363 Diagnostic Radiology in Dental Assessment
Section 3 the Esophagus
364 Embryology, Anatomy, and Function of the Esophagus
365 Congenital Anomalies
366 Obstructing Disorders of the Esophagus
367 Dysmotility
368 Hiatal Hernia
369 Gastroesophageal Reflux Disease
370 Eosinophilic Esophagitis, Pill Esophagitis, and Infective Esophagitis
371 Esophageal Perforation
372 Esophageal Varices
373 Ingestions
Section 4 Stomach and Intestines
374 Normal Development, Structure, and Function of the Stomach and Intestines
375 Pyloric Stenosis and Other Congenital Anomalies of the Stomach
376 Intestinal Atresia, Stenosis, and Malrotation
377 Intestinal Duplications, Meckel Diverticulum, and Other Remnants of the Omphalomesenteric Duct
378 Motility Disorders and Hirschsprung Disease
379 Ileus, Adhesions, Intussusception, and Closed-loop Obstructions
380 Foreign Bodies and Bezoars
381 Peptic Ulcer Disease in Children
382 Inflammatory Bowel Disease
383 Eosinophilic Gastroenteritis
384 Celiac Disease
385 Disorders of Malabsorption
386 Intestinal Transplantation in Children With Intestinal Failure
387 Acute Gastroenteritis in Children
388 Chronic Diarrhea
389 Disorders of Brain-gut Interaction (Functional Gastrointestinal Disorders)
390 Cyclic Vomiting Syndrome
391 Acute Appendicitis
392 Surgical Conditions of the Anus and Rectum
393 Tumors of the Digestive Tract
394 Inguinal Hernias
Section 5 Exocrine Pancreas
395 Embryology, Anatomy, and Physiology of the Pancreas
396 Pancreatic Function Tests
397 Disorders of the Exocrine Pancreas
398 Treatment of Pancreatic Insufficiency
399 Pancreatitis
400 Pancreatic Fluid Collections
401 Pancreatic Tumors
Section 6 the Liver and Biliary System
402 Morphogenesis of the Liver and Biliary System
403 Manifestations of Liver Disease
404 Cholestasis
405 Metabolic Diseases of the Liver
406 Viral Hepatitis
407 Liver Abscess
408 Liver Disease Associated With Systemic Disorders
409 Mitochondrial Hepatopathies
410 Autoimmune Hepatitis
411 Drug- and Toxin-induced Liver Injury
412 Acute Hepatic Failure
413 Cystic Diseases of the Biliary Tract and Liver
414 Diseases of the Gallbladder
415 Portal Hypertension and Varices
416 Liver Transplantation
Section 7 Peritoneum
417 Peritoneal Malformations
418 Ascites
419 Peritonitis
420 Epigastric Hernia
• Part XVII The Respiratory System
Section 1 Development and Function
421 Diagnostic Approach to Respiratory Disease
422 Chronic or Recurrent Respiratory Symptoms
423 Sudden Infant Death Syndrome
424 Brief Resolved Unexplained Events and Other Acute Events in Infants
Section 2 Disorders of the Respiratory Tract
425 Congenital Disorders of the Nose
426 Acquired Disorders of the Nose
427 Nasal Polyps
428 the Common Cold
429 Sinusitis
430 Acute Pharyngitis
431 Tonsils and Adenoids
432 Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, and Peritonsillar Cellulitis/abscess
433 Acute Inflammatory Upper Airway Obstruction (Croup, Epiglottitis, Laryngitis, and Bacterial Tracheitis)
434 Congenital Anomalies of the Larynx, Trachea, and Bronchi
435 Foreign Bodies in the Airway
436 Laryngotracheal Stenosis and Subglottic Stenosis
437 Bronchomalacia and Tracheomalacia
438 Neoplasms of the Larynx, Trachea, and Bronchi
439 Wheezing, Bronchiolitis, and Bronchitis
440 Plastic Bronchitis
441 Emphysema and Overinflation
442 ?1-antitrypsin Deficiency and Emphysema
443 Other Distal Airway Diseases
444 Congenital Disorders of the Lung
445 Pulmonary Edema
446 Acute Aspiration
447 Chronic Recurrent Aspiration
448 Immune and Inflammatory Lung Disease
449 Community-acquired Pneumonia
450 E-cigarette or Vaping Product Use–associated Lung Injury (Evali)
451 Pleurisy, Pleural Effusions, and Empyema
452 Bronchiectasis
453 Pulmonary Abscess
454 Cystic Fibrosis
455 Primary Ciliary Dyskinesia (Immotile Cilia Syndrome, Kartagener Syndrome)
456 Diffuse Lung Diseases in Childhood
457 Pulmonary Hemosiderosis
458 Pulmonary Embolism, Infarction, and Hemorrhage
459 Atelectasis
460 Pulmonary Tumors
461 Pneumothorax
462 Pneumomediastinum
463 Hydrothorax
464 Hemothorax
465 Chylothorax
466 Bronchopulmonary Dysplasia
467 Skeletal Diseases Influencing Pulmonary Function
468 Chronic Respiratory Insufficiency
• Part XVIII The Cardiovascular System
Section 1 Developmental Biology of the Cardiovascular System
469 Cardiac Development
470 the Fetal to Neonatal Circulatory Transition
Section 2 Evaluation of the Cardiovascular System and the Child With a Heart Murmur
471 History and Physical Examination in Cardiac Evaluation
472 Laboratory Cardiac Evaluation
Section 3 Congenital Heart Disease
473 Epidemiology and Genetic Basis of Congenital Heart Disease
474 Evaluation and Screening of the Infant or Child With Congenital Heart Disease
475 Acyanotic Congenital Heart Disease: Left-to-right Shunt Lesions
476 Acyanotic Congenital Heart Disease: Obstructive Lesions
477 Acyanotic Congenital Heart Disease: Regurgitant Lesions
478 Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate With Cyanosis and Respiratory Distress
479 Cyanotic Congenital Heart Disease: Lesions Associated With Decreased Pulmonary Blood Flow
480 Cyanotic Congenital Heart Disease: Lesions Associated With Increased Pulmonary Blood Flow
481 Other Congenital Heart and Vascular Malformations
482 Pulmonary Hypertension
483 General Principles of Treatment of Congenital Heart Disease
Section 4 Cardiac Arrhythmias
484 Disturbances of Rate and Rhythm of the Heart
485 Sudden Death
Section 5 Acquired Heart Disease
486 Infective Endocarditis
487 Rheumatic Heart Disease
Section 6 Diseases of the Myocardium and Pericardium
488 Diseases of the Myocardium
489 Diseases of the Pericardium
490 Tumors of the Heart
Section 7 Cardiac Therapeutics
491 Heart Failure
492 Pediatric Heart and Heart-lung Transplantation
Section 8 Diseases of the Peripheral Vascular System
493 Diseases of the Blood Vessels (Aneurysms and Fistulas)
494 Systemic Hypertension
• Part XIX Diseases of the Blood
Section 1 the Hematopoietic System
495 Development of the Hematopoietic System
496 Anemias
Section 2 Anemias of Inadequate Production
497 Congenital Hypoplastic Anemia (Diamond-blackfan Anemia)
498 Pearson Syndrome
499 Acquired Pure Red Blood Cell Anemia
500 Anemia of Chronic Disease and Renal Disease
501 Congenital Dyserythropoietic Anemias
502 Physiologic Anemia of Infancy
503 Megaloblastic Anemias
504 Iron-deficiency Anemia
505 Other Microcytic Anemias
Section 3 Hemolytic Anemias
506 Definitions and Classification of Hemolytic Anemias
507 Hereditary Spherocytosis
508 Hereditary Elliptocytosis, Hereditary Pyropoikilocytosis, and Related Disorders
509 Hereditary Stomatocytosis Syndromes
510 Paroxysmal Nocturnal Hemoglobinuria and Acanthocytosis
511 Hemoglobinopathies
512 Enzymatic Defects
513 Hemolytic Anemias Resulting From Extracellular Factors—immune Hemolytic Anemias
514 Hemolytic Anemias Secondary to Other Extracellular Factors
Section 4 Polycythemia (Erythrocytosis)
515 Polycythemia
516 Nonclonal Polycythemia
Section 5 the Pancytopenias
517 Inherited Bone Marrow Failure Syndromes With Pancytopenia
518 Acquired Pancytopenias
Section 6 Blood Component Transfusions
519 Red Blood Cell Transfusions and Erythropoietin Therapy
520 Platelet Transfusions
521 Neutrophil (Granulocyte) Transfusions
522 Plasma Transfusions
523 Risks of Blood Transfusions
Section 7 Hemorrhagic and Thrombotic Diseases
524 Hemostasis
525 Hereditary Clotting Factor Deficiencies (Bleeding Disorders)
526 Von Willebrand Disease
527 Hereditary Predisposition to Thrombosis
528 Thrombotic Disorders in Children
529 Postneonatal Vitamin K Deficiency
530 Coagulopathy in Liver Disease
531 Acquired Inhibitors of Coagulation
532 Disseminated Intravascular Coagulation
533 Platelet and Blood Vessel Disorders
Section 8 the Spleen
534 Anatomy and Function of the Spleen
535 Splenomegaly
536 Hyposplenism, Splenic Trauma, and Splenectomy
Section 9 the Lymphatic System
537 Anatomy and Function of the Lymphatic System
538 Abnormalities of Lymphatic Vessels
539 Lymphadenopathy
• Part XX Cancer and Benign Tumors
540 Epidemiology of Childhood and Adolescent Cancer
541 Molecular and Cellular Biology of Cancer
542 Principles of Cancer Diagnosis
543 Principles of Cancer Treatment
544 the Leukemias
545 Lymphoma
546 Central Nervous System Tumors in Childhood
547 Neuroblastoma
548 Neoplasms of the Kidney
549 Soft Tissue Sarcomas
550 Neoplasms of Bone
551 Retinoblastoma
552 Gonadal and Germ Cell Neoplasms
553 Neoplasms of the Liver
554 Complex Vascular Anomalies
555 Rare Tumors
556 Histiocytosis Syndromes of Childhood
• Part XXI Nephrology
Section 1 Glomerular Disease
557 Introduction to Glomerular Diseases
Section 2 Conditions Particularly Associated With Hematuria
558 Clinical Evaluation of the Child With Hematuria
559 Isolated Glomerular Diseases Associated With Recurrent Gross Hematuria
560 Multisystem Disease Associated With Hematuria
561 Tubulointerstitial Disease Associated With Hematuria
562 Vascular Diseases Associated With Hematuria
563 Anatomic Abnormalities Associated With Hematuria
564 Lower Urinary Tract Causes of Hematuria
Section 3 Conditions Particularly Associated With Proteinuria
565 Clinical Evaluation of the Child With Proteinuria
566 Conditions Associated With Proteinuria
567 Nephrotic Syndrome
Section 4 Tubular Disorders
568 Tubular Function
569 Renal Tubular Acidosis
570 Nephrogenic Diabetes Insipidus
571 Inherited Tubular Transport Abnormalities
572 Renal Failure
573 Renal Transplantation
• Part XXII Urologic Disorders in Infants and Children
574 Congenital Anomalies and Dysgenesis of the Kidneys
575 Urinary Tract Infections
576 Vesicoureteral Reflux
577 Obstruction of the Urinary Tract
578 Anomalies of the Bladder
579 Neuropathic Bladder
580 Enuresis and Voiding Dysfunction
581 Anomalies of the Penis and Urethra
582 Disorders and Anomalies of the Scrotal Contents
583 Trauma to the Genitourinary Tract
584 Urinary Lithiasis
• Part XXIII Gynecologic Problems of Childhood
585 Gynecologic History and Physical Examination
586 Vulvovaginitis
587 Vaginal Bleeding in the Prepubertal Child
588 Breast Health
589 Polycystic Ovary Syndrome and Hirsutism
590 Gynecologic Neoplasms and Prevention Methods for Human Papillomavirus Infections in Adolescents
591 Vulvovaginal and Müllerian Anomalies
592 Gynecologic Care for Adolescents With Special Needs
593 Female Genital Mutilation
• Part XXIV the Endocrine System
Section 1 Disorders of the Hypothalamus and Pituitary Gland
594 Hormones of the Hypothalamus and Pituitary
595 Hypopituitarism
596 Diabetes Insipidus
597 Other Abnormalities of Arginine Vasopressin Metabolism and Action
598 Hyperpituitarism
599 Physiology of Puberty
600 Disorders of Pubertal Development
Section 2 Disorders of the Thyroid Gland
601 Thyroid Development and Physiology
602 Disorders of Thyroxine-binding Globulin
603 Hypothyroidism
604 Thyroiditis
605 Goiter
606 Thyrotoxicosis
607 Carcinoma of the Thyroid
608 Autoimmune Polyglandular Syndromes
609 Multiple Endocrine Neoplasia Syndromes
Section 3 Disorders of the Parathyroid Gland
610 Hormones and Peptides of Calcium Homeostasis and Bone Metabolism
611 Hypoparathyroidism
612 Pseudohypoparathyroidism
613 Hyperparathyroidism
Section 4 Disorders of the Adrenal Gland
614 Physiology of the Adrenal Gland
615 Adrenocortical Insufficiency and Altered Sensitivity to Corticosteroids
616 Congenital Adrenal Hyperplasia and Related Disorders
617 Adrenocortical Tumors and Masses
618 Virilizing and Feminizing Adrenal Tumors
619 Cushing Syndrome
620 Primary Aldosteronism
621 Pheochromocytoma
Section 5 Disorders of the Gonads
622 Development and Function of the Gonads
623 Hypofunction of the Testes
624 Pseudoprecocity Resulting From Tumors of the Testes
625 Gynecomastia
626 Hypofunction of the Ovaries
627 Pseudoprecocity Resulting From Lesions of the Ovary
628 Disorders of Sex Development
Section 6 Diabetes Mellitus in Children
629 Diabetes Mellitus
• Part XXV the Nervous System
630 Neurologic Evaluation
631 Congenital Anomalies of the Central Nervous System
632 Deformational Plagiocephaly
633 Seizures in Childhood
634 Conditions That Mimic Seizures
635 Headaches
636 Neurocutaneous Syndromes
637 Movement Disorders
638 Encephalopathies
639 Neurodegenerative Disorders of Childhood
640 Demyelinating Disorders of the Central Nervous System
641 Pediatric Stroke
642 Central Nervous System Vasculitis
643 Central Nervous System Infections
644 Brain Abscess
645 Idiopathic Intracranial Hypertension (Pseudotumor Cerebri)
646 Spinal Cord Disorders
• Part XXVI Neuromuscular Disorders
647 Evaluation and Investigation of Neuromuscular Disorders
648 Developmental Disorders of Muscle
649 Muscular Dystrophies
650 Endocrine and Toxic Myopathies
651 Metabolic Myopathies and Channelopathies
652 Disorders of Neuromuscular Transmission and of Motor Neurons
653 Hereditary Motor-sensory Neuropathies
654 Toxic Neuropathies
655 Autonomic Neuropathies
656 Guillain-barré Syndrome
657 Bell Palsy
• Part XXVII Disorders of the Eye
658 Growth and Development of the Eye
659 Examination of the Eye
660 Abnormalities of Refraction and Accommodation
661 Disorders of Vision
662 Abnormalities of Pupil and Iris
663 Disorders of Eye Movement and Alignment
664 Abnormalities of the Lids
665 Disorders of the Lacrimal System
666 Disorders of the Conjunctiva
667 Abnormalities of the Cornea
668 Abnormalities of the Lens
669 Disorders of the Uveal Tract
670 Disorders of the Retina and Vitreous
671 Abnormalities of the Optic Nerve
672 Childhood Glaucoma
673 Orbital Abnormalities
674 Orbital Infections
675 Injuries to the Eye
• Part XXVIII The Ear
676 General Considerations and Evaluation of the Ear
677 Hearing Loss
678 Congenital Malformations of the Ear
679 External Otitis (Otitis Externa)
680 Otitis Media
681 Acute Mastoiditis
682 the Inner Ear and Diseases of the Bony Labyrinth
683 Traumatic Injuries of the Ear and Temporal Bone
684 Tumors of the Ear and Temporal Bone
• Part XXIX The Skin
685 Morphology of the Skin
686 Dermatologic Evaluation of the Patient
687 Principles of Dermatologic Therapy
688 Dermatologic Diseases of the Neonate
689 Cutaneous Defects
690 Ectodermal Dysplasias
691 Vascular Anomalies
692 Cutaneous Nevi
693 Hyperpigmented Lesions
694 Hypopigmented Lesions
695 Vesiculobullous Disorders
696 Eczematous Disorders
697 Photosensitivity
698 Diseases of the Epidermis
699 Disorders of Keratinization
700 Diseases of the Dermis
701 Diseases of Subcutaneous Tissue
702 Disorders of the Sweat Glands
703 Disorders of Hair
704 Disorders of the Nails
705 Disorders of the Mucous Membranes
706 Cutaneous Bacterial Infections
707 Cutaneous Fungal Infections
708 Cutaneous Viral Infections
709 Arthropod Bites and Infestations
710 Acne
711 Tumors of the Skin
712 Nutritional Dermatoses
• Part XXX Bone and Joint Disorders
Section 1 Orthopedic Problems
713 Orthopedic Growth and Development
714 Orthopedic Evaluation of the Child
715 the Foot and Toes
716 Torsional and Angular Deformities of the Limb
717 Leg-length Discrepancy
718 the Knee
719 the Hip
720 the Spine
721 the Neck
722 the Upper Limb
723 Arthrogryposis
724 Common Fractures
725 Osteomyelitis
726 Septic Arthritis
Section 2 Sports Medicine
727 Prevention of Injuries
728 Management of Musculoskeletal Injury
729 Sports-related Traumatic Brain Injury (Concussion)
730 Cervical Spine Injuries
731 Heat Injuries
732 Nutrition and Endocrine Conditions in Athletes
733 Performance-enhancing Aids
734 Specific Sports and Associated Injuries
Section 3 the Skeletal Dysplasias
735 General Considerations in Skeletal Dysplasias
736 Disorders Involving Cartilage Matrix Proteins
737 Disorders Involving Transmembrane Receptors
738 Disorders Involving Ion Transporters
739 Disorders Involving Transcription Factors
740 Osteopetrosis and Other Disorders Involving Defective Bone Resorption
741 Other Inherited Disorders of Skeletal Development
742 Osteogenesis Imperfecta
Section 4 Connective Tissue Disorders
743 Marfan Syndrome
744 Ehlers-danlos Syndrome
745 Cutis Laxa
Section 5 Metabolic Bone Disease
746 Bone Structure, Growth, and Hormonal Regulation
747 Hypophosphatasia
748 Hyperphosphatasia
749 Osteoporosis
• Part XXXI Rehabilitation Medicine
750 Rehabilitation for Traumatic Brain Injury
751 Spinal Cord Injury and Autonomic Dysreflexia Management
752 Spasticity
753 Birth Brachial Plexus Palsy
754 Meningomyelocele (Spina Bifida)
755 Upper and Lower Extremity Assistive Devices
756 Health and Wellness for Children With Disabilities
• Part XXXII Environmental Health
757 Overview of Environmental Health and Children
758 Biologic Effects of Ionizing Radiation on Children
759 Chemical Pollutants
760 Heavy Metal Intoxication
761 Lead Poisoning
762 Nonbacterial Food Poisoning
763 Biological and Chemical Terrorism
764 Mass Psychogenic Illness
765 Animal and Human Bites
766 Rat Bite Fever
767 Mpox (Monkeypox)
768 Envenomations
• Part XXXIII Laboratory Medicine (Available in Digital Format Only)
769 Laboratory Testing in Infants and Children
770 Reference Intervals for Laboratory Tests and Procedures

Covering every aspect of general pediatric practice, as well as details for many pediatric subspecialists, Nelson Textbook of Pediatrics, 22nd Edition, brings you fully up to date with everything from rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today. Edited and written by experts and prominent members of the pediatric medical community, this comprehensive two-volume reference covers both the science and art of pediatric practice. It remains the reference of choice among pediatricians, pediatric residents, and others involved in the care of young patients, delivering the information you need in a concise, easy-to-use format for everyday reference and study.

• Features a user-friendly format with short chapters and subchapters that allow you to quickly find the information you need.
• Includes more than 60 new chapters on topics covering the impact of social factors on children’s health, the impact of genetic discoveries on understanding diagnosing and treating childhood diseases, updating of current evidenced based diagnostic and therapeutic approaches to childhood diseases, and more.
• Offers new and expanded information on gene therapy; interferonopathies; reactive infectious mucocutaneous eruption (RIME); e-cigarette or vaping use-associated lung injury (EVALI); monkeypox; food protein-induced enterocolitis syndrome (FPIES); signaling pathway disorders; ciliopathies; very early onset inflammatory bowel disease; Epstein-Barr virus susceptibility disorders; marijuana smoke exposure; and much more.
• Features hundreds of new figures and tables throughout for visual clarity and quick reference, real-time videos, and regular updates online, written exclusively for Nelson.
• Provides fresh perspectives from two new associate editors: Abigail M. Schuh and Cara L. Mack, both of Medical College of Wisconsin.
• Remains your indispensable source for definitive, evidence-based answers on every aspect of pediatric care.
• An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

• Robert M. Kliegman, MD, Professor & Chair Emeritus, Department of Pediatrics - Medical College of Wisconsin Nelson Undiagnosed & Rare Disease Program.
• Joseph W. St. Geme III, MD, Chair, Department of Pediatrics, Professor of Pediatrics and Microbiology, Perelman School of Medicine at the University of Pennsylvania and Physician-in-Chief, Leonard and Madlyn Abramson Endowed Chair in Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania