NEOPLASTIC MIMICS IN SOFT TISSUE AND BONE PATHOLOGY

1. NEOPLASTIC MIMICS: GENERAL CONSIDERATIONS
Introduction
Philosophical and Practical Issues
Topographic Distribution and Biologic Nature of Neoplastic Mimics
Idiopathic Neoplastic Mimics
Reparative/Posttraumatic Neoplastic Mimics
Developmental Neoplastic Mimics
“Functional” Neoplastic Mimics
Iatrogenic Neoplastic Mimics
Infectious Neoplastic Mimics
2. GENERAL CONSIDERATIONS IN SOFT TISSUE AND BONE PATHOLOGY
3. MIMICS OF ADIPOCYTIC NEOPLASMS
Fat Necrosis
Intramuscular Angioma
Sclerosing Mesenteritis
Silicone Reaction
Massive Localized Lymphedema
Prolapsed Orbital Fat
Myelolipoma
Lipoma (Including Intramuscular Lipoma and Lipomatosis)
Spindle Cell Lipoma/Pleomorphic Lipoma
Hibernoma
Lipoblastoma
4. MIMICS OF FIBROBLASTIC/MYOFIBROBLASTIC AND FIBROHISTIOCYTIC NEOPLASMS
Mimics of Fibroblastic/Myofibroblastic Neoplasms
Nodular Fasciitis
Proliferative Fasciitis/Proliferative Myositis
Ischemic Fasciitis
Fibroma of Tendon Sheath
Desmoid Fibromatosis
Pseudosarcomatous Myofibroblastic Proliferation
Dermatomyofibroma
Cellular Benign Fibrous Histiocytoma
Mammary-Type Myofibroblastoma
Cellular Angiofibroma
Soft Tissue Perineurioma
Superficial Angiomyxoma
Intramuscular Myxoma (Including Cellular Myxoma)
Selected Mimics of Pediatric Fibroblastic/Myofibroblastic Neoplasms
Fibrous Hamartoma of Infancy
Infantile Myofibromatosis
Mimics of Fibrohistiocytic Neoplasms
Reactive and Inflammatory Processes
Cellular Neurothekeoma
Cellular Benign Fibrous Histiocytoma
5. MIMICS OF SMOOTH MUSCLE AND SKELETAL MUSCLE NEOPLASMS
Mimics of Smooth Muscle Neoplasms
Myopericytoma/Myofibroma
Pseudosarcomatous Myofibroblastic Proliferation
Angioleiomyoma
Cellular Schwannoma
EBV-Associated Smooth Muscle Neoplasms
Mimics of Skeletal Muscle Neoplasms
Crystal Storing Histiocytosis
Hibernoma
Granular Cell Tumor
Proliferative Fasciitis/Proliferative Myositis
Fetal Rhabdomyoma
6. MIMICS OF VASCULAR NEOPLASMS
Intravascular Papillary Endothelial Hyperplasia
Reactive Angioendotheliomatosis
Epithelioid Angiomatous Nodule
Bacillary Angiomatosis
Symplastic Hemangioma
Microvenular Hemangioma
Hobnail Hemangioma
Pseudoangiomatous Stromal Hyperplasia
Perilobular Hemangioma
Anastomosing Hemangioma of the Genitourinary Tract
Vascular Transformation of Lymph Node Sinuses
Spindle Cell Hemangioma
Epithelioid Hemangioma of Soft Tissue and Bone
Splenic Hemangioma and Littoral Cell Angioma
Atypical Postradiation Vascular Proliferation
Kaposi Sarcoma
7. MIMICS OF NEUROECTODERMAL NEOPLASMS
Traumatic Neuroma
Solitary Circumscribed Neuroma
Degenerative Atypia in Schwannoma (and Other Benign Nerve Sheath Tumors)
Cellular Schwannoma
Epithelioid Schwannoma
Diffuse Neurofibroma
Plexiform Neurofibroma
Hybrid Nerve Sheath Tumors
8. MIMICS OF NEOPLASMS OF UNCERTAIN DIFFERENTIATION AND GASTROINTESTINAL STROMAL TUMORS
Mimics of Neoplasms of Uncertain Differentiation
Atypical Fibroxanthoma
Angiomyofibroblastoma
Granuloma Annulare
Aneurysmal, Cellular, and Deep Variants of Fibrous Histiocytoma
Soft Tissue Chondroma
Cellular Neurothekeoma
Myoepithelioma of Soft Tissue
Schwannoma
Mimics of Gastrointestinal Stromal Tumors
Schwannoma
Leiomyoma
9. MIMICS OF OSSEOUS NEOPLASMS
Myositis Ossificans
Giant Cell Reparative Granuloma
Giant Cell Tumor of Bone
Aneurysmal Bone Cyst
Osteoid Osteoma and Osteoblastoma
Subungal Exostosis
Bizarre Parosteal Osteochondromatous Proliferation
Osteochondroma
Fibrous Dysplasia
Desmoplastic Fibroma
10. MIMICS OF CARTILAGINOUS NEOPLASMS
Osteochondroma
Chondroma
Chondromyxoid Fibroma
Chondroblastoma
Bizarre Parosteal Osteochondromatous Proliferation
Synovial Chondromatosis
References
Index

Neoplastic mimics or "pseudotumors" can simulate neoplasms on all levels of analysis--clinical, radiologic, and pathologic--and thus represent particular diagnostic pitfalls for the pathologist that can ultimately lead to therapeutic misdirection.
This book provides the pathologist with detailed morphologic descriptions and diagnostic guidance in recognizing these neoplastic mimics as they occur in the soft tissues and bones. In addition, descriptions and diagnostic guidance are provided for the range of lesions that are considered benign neoplasms but may mimic malignant tumors. Throughout the book comparisons of neoplastic mimics with true neoplasms (and benign neoplasms with sarcomas) are provided, at clinical, gross, and histologic levels. In the presentation of every entity, the points that contribute to differential diagnosis are emphasized.
More than 300 color images and this analysis of neoplastic and malignant mimics guide the pathologist through recognizing and distinguishing the unusual variants, morphologic anomalies and misleading features that may easily lead to an inaccurate interpretation and missed diagnosis. Since many of entities described are uncommon, Neoplastic Mimics in Soft Tissue and Bone Pathologyemphasizes imaging and clinical correlations throughout to support the pathologist as consultant to the entire diagnostic and clinical management team. Every pathologist who sees soft tissue and bone cases will find this book an invaluable working tool to ensure accurate diagnosis.

Neoplastic Mimics in Soft Tissue and Bone Pathology features:
• Over 300 high-quality images showing the full range of neoplastic and malignant mimics in soft tissue and bone specimens
• Concise, specific text descriptions make the book easy to use as a visual reference
• Expert authors guide the reader to recognizing and distinguishing misleading specimens

Authors
• Vickie Y. Jo, MD is Instructor, Department of Pathology, Harvard Medical School/Brigham and Women's Hospital, Boston, MA, USA.
• Jason L. Hornick, MD, PhD is Director of Surgical Pathology, Director, Immunohistochemistry Laboratory, Department of Pathology, Harvard Medical School/Brigham and Women's Hospital, Boston, MA, USA. Dr. Hornick is an emerging star in the area of soft tissue pathology and was awarded the Arthur Purdy Stout Society of Surgical Pathologists Annual Prize in 2012, in recognition of significant career achievements in surgical pathology under the age of 45 years. He has published previously with Elsevier.