NEURAL STEM CELLS IN HEALTH AND DISEASE

This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders.
Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions.
A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Author
Ashok K Shetty. Texas A&M Health Science Center College of Medicine, USA.

Contents:
•Neural Stem Cells in Health and Disease (Ashok K Shetty)
•Physiology of Stem Cells in the Hippocampal Dentate Gyrus (J Martin Wojtowicz and Yao Fang Tan)
•Age-Related Changes to the Subventricular Zone Stem Cell Niche (Matthew B Eastman, Rebecca L Acabchuk, and Joanne C Conover)
•Neural Stem Cells for Intrinsic Brain Repair in Aging and Neural Degeneration (Lalitha Madhavan)
•Neural Stem Cells and the Effects of Cancer Therapy (Lauren S Y Wood and Michelle Monje)
•Neural Stem Cell Activity and Neurogenesis After Stroke (Ashok K Shetty and Kunlin Jin)
•Neurogenesis and Dentate Granule Cell Development in Epilepsy (Bethany E Hosford and Steve C Danzer)
•Endogenous Neural Stem Cell Response to Traumatic Brain Injury (Aminul I Ahmed and William P Gray)
•Neural Stem Cells in Alzheimer's Disease (Orly Lazarov)
•Roles of Neural Stem Cells in Alcohol Use Disorders (Jennifer L Wagner, Emily A Barton, Chelsea R Geil, J Leigh Leasure, and Kimberly Nixon)
•Neural Stem Cells in Methamphetamine Addiction (Chitra D Mandyam)
•Studies on Developmental Exposures to Anesthetic Agents and Stem Cell Derived Models (Fang Liu, Merle G Paule, Tucker A Patterson, Cheng Wang, and William Slikker, Jr)
•Induced Neurogenesis as a Mechanism for Adult Central Nervous System Regeneration (Derek K Smith, Wenze Niu, and Chun-Li Zhang)
•Neural Stem Cell Therapy for Parkinson's Disease (Marcel M Daadi)
•Stem Cell-Based Neuroprotective Strategies in Stroke (Ike dela Peña, Alesia Antoine, Stephanny Reyes, Diana Hernandez, Sandra Acosta, Mibel Pabon, Naoki Tajiri, Yuji Kaneko, and Cesar V Borlongan)
•Neural Stem Cell Therapy for Easing Status Epilepticus Induced Hippocampus Dysfunction and Chronic Temporal Lobe Epilepsy (Ashok K Shetty and Bharathi Hattiangady)
•Prospects of Neural Stem Cell Therapy for Alzheimer's Disease (Samuel E Marsh and Mathew Blurton-Jones)
•Neural Stem Cell Therapy for Spinal Cord Injury (Christopher J Haas, Joseph F Bonner, George Ghobrial, and Itzhak Fischer)
•Generating Different Neural Cell Types from iPSCs for Screening and Cell Therapy for CNS Disorders (Mohan C Vemuri and Mahendra S Rao)