NEUROBIOLOGY OF DISEASE. 2ND EDITION

• SECTION I: Movement Disorders (Joel Perlmutter, Washington University)
1. History of Parkinsonism
2. Parkinson Disease: Pathophysiology, Clinical Manifestations and Course including Diagnosis and Differential Diagnosis
3. Parkinson Disease: Treatment, Current Clinical Trials
4. Parkinson Syndromes: Multiple System Atrophy
5. Parkinson Syndromes: Progressive Supranuclear Palsy
6. Parkinson Syndromes: Corticobasal Degeneration
7. Huntington Disease: Etiology, Genetics, and Clinical Manifestations
8. Huntington Disease: Treatment, Current Clinical Trials
9. Essential Tremors
10. Dystonia: History and Classification
11. Dystonia: Pathophysiology, Clinical Manifestations and Course Including Diagnosis, and Differential Diagnosis, Treatment, Current Clinical Trials
12. Paroxysmal Dyskinesias
13. The Expanded Polyglutamine Tract Spinocerebellar Ataxias
14. Ataxias: Autosomal Recessive and other Ataxias
• SECTION II: Dementias (David Knopman, Mayo Clinic)
15. Alzheimer's Disease: Pathology and Pathogenesis
16. Alzheimer's Disease: Clinical Manifestations and Diagnostic/Differential Diagnosis
17. Alzheimer's Disease: Management and Treatment
18. Frontotemporal Degenerations
19. Diagnosis and Therapy for Lewy Body Dementia
20. Pathogenesis of Lewy Body Dementia
21. Cerebrovascular Dementia
• SECTION III: Motorneuron Diseases (Merit Cudkowicz, Massachusetts General Hospital, Harvard University)
22. Types of MNDS
23. Clinical Presentations, Diagnostic Criteria, Lab Testing
24. Symptomatic Care
25. ALS: Epidemiology
26. ALS: Pathogenesis
27. ALS: Insights from Genetics
28. ALS: In Vitro and In Vivo Disease Models
29. ALS Pathology
30. ALS: Clinical Trials Past Reflections Informing New Directions
31. Upper Motor Neuron Disorders: Hereditary Spastic Paraplegia and Primary Lateral Sclerosis
32. UMN Disorders (HSP and PLS): Pathogenesis, Insights from Genetics, In Vitro and In Vivo Disease Models, Pathology and Clinical Trials
33. SMA: Pathogenesis
34. SMA: Insights from Genetics
35. SMA: In Vitro and In Vivo Models of Spinal Muscular Atrophy
• SECTION IV: Paroxysmal Disorders (Solomon Moshe, Albert Einstein College of Medicine)
36. Biological Basis of Primary Generalized Epilepsies-Genetics
37. Biological Basis of Primary Generalized Epilepsies - Pathophysiology
38. Temporal Lobe Epilepsy
39. Focal Cortical Dysplasias
40. Biological Bases of Symptomatic Generalized Epilepsies in Children
41. Epilepsies that Occur Predominantly in Girls
42. Epidemiology of Epilepsy: Incidence, Prevalence, and Risk Factors
43. Clinical Presentation, Diagnosis, and Course- Epilepsy Syndromes with Focal Seizures
44. Medical Management of Epilepsy
45. Neuroimaging in Epilepsy
47. Alternative Therapies for Epilepsy: Dietary Treatments
48. Migraine and Other Headache Disorders
49. Neurobiology of Migraine
• SECTION V: Pediatric Neurology and Developmental Disorders (Tanjala Gipson and Deepa Menon, Kennedy
50. Autism and Intellectual Disabilities: Overview of Autism and Intellectual Disabilities
51. Tuberous Sclerosis Complex: Pediatric Aspects
52. Neurofibromatosis Type 1
53. Neurobiology of Autism and Intellectual Disability: Fragile X Syndrome
54. Autism and Intellectual Disabilities: PTEN Gene mutation
55. Rett Syndrome
56. Angelman Syndrome
57. Down Syndrome
58. Coffin-Lowry Syndrome
59. Congenital Hypothyroidism
60. Pediatric Neurotransmitter Disorders
61. Attention Deficit-Hyperactivity Disorder
62. Diseases of Mitochondrial Energy Metabolism
63. Genetic Metabolic Disorders: MethylmalonicAciduria
64. The Urea Cycle Disorders
65. Phenylketonuria
66. Cerebral Creatine Deficiency Disorders
67. Congenial Disorders of Glycosylation
68. Glutaric Aciduria Type I
69. Lysosomal Storage Disroders
70. Peroxisomal Disorders
71. Leukodystrophies
72. Cerebral Palsy
73. Neonatal Brain Injuries
74. The Neurobiology of Encephalopathy of Prematurity
75. Epilepsy Syndromes in Childhood
76. Migraine and Headaches in Children
77. Congenital Hydrocephalus
78. Spina Bifida and Related Conditions
79. Smith-Lemli-Opitz Syndrome
80. Sickle Cell Anemia
• SECTION VI: Neuroimmunological Diseases (Carlos Pardo-Villamizar, Johns Hopkins University)
81. The Epidemiology of Multiple Sclerosis: An Historical Perspective
82. Multiple Sclerosis: Pathology
83. Multiple Sclerosis: MRI and Other Imaging Approaches in MS
84. Multiple Sclerosis: White Matter vs Grey Matter Involvment (The Cause of Disability in MS)
85. Multiple Sclerosis: Monitoring disease activity and progression
86. Symptomatic Treatment of Multiple Sclerosis
87. Exercise and Multiple Sclerosis
88. Multiple Sclerosis: Disease Modifying Therapies
89. Neuromyelitis Optica
90. Acute Disseminated Encephalomyelitis
93. Paraneoplastic Neurological Disorders
94. Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Encephalitis
95. Other Proven and Putative Autoimmune Disorders of the CNS: Anti-GAD Associated Neurological Disorders; Stiff-Person syndrome, Cerebellar Ataxia, Progressive Encephalopathy with Rigidity and Myoclonus (PERM), and Encephalitis.
96. Other Proven and Putative Autoimmune Disorders of the CNS: Hashimoto's Encephalopathy
97. Other Proven and Putative Autoimmune Disorders of the CNS: Neuro-Bechet's Syndrome
98. Post-Streptococcal Movement Disorders
99. Rasmussen Encephalitis
100. Autoimmune Encephalitis
101. Other Proven and Putative Autoimmune Disorders of the PNS: Myasthenia gravis
102. Vasculitis of the central nervous system
• SECTION VII: Cerebrovascular Diseases (Harold Adams, University of Iowa)
103. Stroke Epidemiology and Impact: Mortality, Incidence, Prevalence, Stroke Subtypes, Sex, Race/Ethnicity, Geography U.S. and World
104. Acute Ischemic Stroke
105. Neuroimaging of Acute Stroke
106. Common Risk Factors and Medical Prevention Therapies
107. Surgical and Radiologic Intervention for Prevention of Ischemic Stroke
108. Unusual Causes of Stroke
109. Pediatric Stroke
110. Vascular Biology of Cerebral Ischemia
111. Intracerebral Hemorrhage
112. Subarachnoid Hemorrhage
113. Genetics of Cerebral Ischemia including Genetic Syndromes
114. Molecular Targets of Cerebral Ischemia
115. Sturge-Weber Syndrome and related Cerebrovascular Malformation Syndromes.
• SECTION VIII: Peripheral and Autonomic Nervous System Disorders and Pain (Nicholas Maragakis, Johns Hopkins University)
116. Neuropathies Associated with Infection or Toxic Exposure
117. Mechanisms Contributing to the Development and Progression of Diabetic Polyneuropathy
118. Diabetic and PreDiabetic Neuropathy
119. Anatomy, Localization, and Pattern Recognition of Peripheral Neuropathy
120. Drug Discovery of Neuropathic Pain
121. Neuropathies, Autonomic
122. Animal Models of Peripheral Neuropathy and Neuropathic Pain
123. Diagnostic Tests and Clinical Scales for Peripheral Neuropathy
124. Complex Regional Pain Syndrome
125. Entrapment Neuropathies
126. Demyelinating Neuropathies
127. Immune Mediated Neuropathies
128. Radiculopathy and Plexopathy
• SECTION IX: Neoplastic and Paraneoplastic Diseases (Lisa DeAngelis, Memorial Slaon-Kettering Cancer Center)
129. Infiltrative Astrocytomas: WHO grade II - Diffuse Astrocytoma; WHO grade III - Anaplastic Astrocytoma
130. Glioblastomas
131. Oligodendrogliomas
132. Primary CNS Tumores: Ependymomas
133. Meningiomas
134. Pineal Region Neoplasms
135. Pituitary Tumors
136. Primary Central Nervous System Lymphoma
137. Familial CNS Tumor Syndromes: Neurofibromatosis Type 1
138. Familial CNS Tumor Syndromes: Neurofibromatosis Type-2
139. Familial CNS Tumor Syndromes: Tuberous Sclerosis
140. Familial CNS Tumor Syndromes: Von Hippel-Lindau Disease
141. Pediatric Tumors: Pontine Glioma
142. Pediatric Tumors: Medulloblastoma
143. Pediatric Tumors: Cerebellar Astrocytoma
144. Brain Metastases
145. Overview: Other Proven and Putative Autoimmune Disorders of the CNS
146. Chemotherapy and Radiation Therapy
• SECTION X: Infectious Diseases of the Nervous System (Karen Roos, Indiana University)
147. Acute Bacterial Meningitis
148. Cerebrospinal Fluid
149. History of Human Immunodeficiency Virus Infection and the Nervous System
150. HIV-Associated Neurocognitive Disorders
151. HIV Infection: Opportunistic Infections in HIV-Infected Individuals
152. Varicella Zoster Virus Infection of the Nervous System
153. Brain Abcess
154. Epidural Abscess and Sudural Empyema
155. Spinal Epidural Abcess
156. Transverse Myelitis
157. CNS Tuberculosis
158. Rabies
159. Disorders Caused by Botulinum Toxin and Tetanus Toxin
160. Rickettsial Diseases
161. Ehrlichial Diseases
162. Nervous System Lyme Disease
163. Congenital and Perinatal Viral Infections
164. Neurologic Manifestations of HTLV-1
165. Fungal Infections of the Central Nervous System
166. Malaria
167. Babesiosis
168. Amebic Encephalitis
169. Prions
170. Neurological Complications of Infective Endocarditis
171. Post-Infectious Encephalitis
172. Central Nervous System Whipple Disease
173. Progressive Multifocal Leukoencephalopathy
• SECTION XI: Sleep Disturbances (Mark Dyken, University of Iowa)
174. REM Sleep Behavior Disorder
175. Restless Leg Syndrome and Periodic Limb Movements in Sleep
176. Insomnia
177. Sleep Apnea
178. Neurobiology of Circadian Rhythm Disorders
• SECTION XII: Substance Abuse and Toxicological Disorders (Barry Kosofsky, Weil-Cornell University Medical Centers)
179. Neurologic Manifestations of Organic Chemicals
180. Neurobiology of Drug Addiction and Clinical Aspects of Drug Abuse
181. Neurological Effects of Marine Toxins
182. Fetal Alcohol Syndrome
183. Fetal Exposure to Tobacco and Cannabis
184. Neurobiology of Child Maltreatment and Psychological Trauma
185. Neurobiology of Intrauterine Opiate and Cocaine Exposure
• SECTION XIII: Neurologic Manifestations of Medical Disorders (John Probasco, Johns Hopkins University)
186. Electrolyte Disturbances
187. Nutritional Deficiencies
188. Alcohol Abuse
189. Thyroid Disease
190. Parathyroid, Adrenal, Ovarian, Testicular and Pituitary Disease
191. Cardiac Disease
192. Neurobiology of Brain Injury after Cardiac Arrest
193. Gastrointestinal Disease
194. Neurological Manifestations of Renal Disease
195. Systemic Lupus Erythematosis
196. Neurologic Manifestations of Hematological Disease

The second edition of Neurobiology of Disease includes nearly 200 articles surveying all major disorders of the nervous system in both adults and children, focusing on relevant diagnosis and treatments from the perspective of cutting edge clinical and basic neurobiological research.
Akin to an encyclopedia of every neurologic disorder, this comprehensive work is ideal for graduate and medical school students, residents, and candidates preparing for their board certification examinations. Each chapter is illustrated with detailed figures, supplemented with descriptive and diagnostic tables, and thoroughly referenced for further investigations.
The book's editors, Michael Johnston, Harold Adams, and Ali Fatemi bring their unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this new edition, the following Section Editors provided oversight of their respective sections:

• Movement Disorders- Joel Perlmutter, Washington University
• Dementias- David Knopman, Mayo Clinic
• Motorneuron Diseases- Merit Cudkowicz, Massachusetts General Hospital
• Paroxysmal Disorders- Solomon Moshe, Albert Einstein College of Medicine
• Pediatric Neurology and Developmental Disorders- Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University
• Neuroimmunological Diseases- Carlos Pardo-Villamizar, Johns Hopkins University
• Cerebrovascular Diseases- Harold Adams, University of Iowa
• Peripheral and Autonomic Nervous System Disorders and Pain- Nicholas Maragakis, Johns Hopkins University
• Neoplastic and Paraneoplastic Diseases- Lisa DeAngelis, Memorial Slaon-Kettering Cancer Center

Features
• Includes nearly 200 brief, but substantial survey articles on all the major disorders of the nervous system in both adults and children;
• Includes relevant diagnoses and treatment from the perspective of cutting edge clinical and basic neurobiological research;
• Each chapter is illustrated with detailed figures, supplemented with descriptive and diagnostic tables, and thoroughly referenced for further investigations;
• Written by clinicians who are experts in their fields and active participants in clinical and basic research.

Authors
• Michael V Johnston, MD, Johns Hopkins University, Edited.
• Harold P Adams, MD, University of Iowa, and Edited
• Seyed Ali Fatemi, MD, Johns Hopkins University