NEURODEGENERATION

1 Pathology of Brain Aging, 1
2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies, 12
3 Prion Degeneration, 25
4 Excitotoxicity, 37
5 Etiology and Pathogenesis of Parkinson Disease, 46
6 Parkinson Disease: Treatment Options – Surgical Therapy, 53
7 Multiple System Atrophy: Clinical, Genetics, and Neuropathology, 58
8 Progressive Supranuclear Palsy, 72
9 Dementia with Lewy Bodies, 83
10 Corticobasal Degeneration, 93
11 Alzheimer’s Disease, 102
12 Frontotemporal Dementia, 115
13 Prion Diseases and Other Rapidly Progressive Dementias, 126
14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis, 137
15 Hereditary Spastic Paraplegia, 161
16 Spinal Muscular Atrophy, 179
17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease), 202
18 Optic Neuropathies, 211
19 Peripheral Nerve Neuropathies Including Charcot–Marie–Tooth Disease, 218
20 Axonal Loss and Neurodegeneration in Multiple Sclerosis, 238
21 Huntington’s Disease and Other Choreas, 248
22 Spinocerebellar Ataxias, 284
23 Ataxia Telangiectasia, 296
24 Niemann–Pick Disease, 303
25 X-linked Adrenoleukodystrophy, 309
26 Neurodegeneration with Brain Iron Accumulation, Wilson Disease, and Manganism, 317

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.

• Presents a clinically oriented guide to the diseases caused by neurodegeneration
• Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually
• Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases
• Edited by globally leading authorities on the subject, and written by expert contributing authors

Author Information
• Professor Anthony Schapira is Professor of Neurological Science and Head of the Department of Clinical Neuroscience at the UCL Institute of Neurology, London, UK and Chairman of Clinical Neurosciences Specialties.
• Zbigniew Wszolek, MD, is Professor of Neurology in the Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
• Ted M.Dawson, MD, PhD, is Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases and Scientific Director in the Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
• Professor Nicholas Wood is Research Director of the UCL Institute of Genetics and Galton Professor of Genetics at UCL National Hospital for Neurology and Neurosurgery, Institute of Neurology, London, UK.