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98,80 €Foreword vii
List of Contributors ix
Series Preface xi
About the Companion Website xiii
1 Neuroanatomy of Feeding Pathways 1
2 Afferent Endocrine Control of Eating 24
3 Ontogeny of Neuroendocrine Feeding Circuits 55
4 Hypothalamic Peptides and Meal Patterns 76
5 Food Hedonics: Insight from Animal Models 90
6 Functional and Anatomical Dissection of Feeding Circuits 112
7 Exploring Appetite and Hypothalamic Circuitry through Manipulating Gene Expression 134
8 Electrophysiology of the Appetite-Regulating Circuits of the Hypothalamus 151
9 Functional Neuroimaging of Appetite and Gut–Brain Interactions 174
10 Appetite Disorders: From Binge Eating to Anorexia Nervosa 201
11 Future Prospects of the Management of Appetite Disorders Bariatric Surgery 224
12 Discovery of New Drugs for Weight Loss and Prevention of Weight Regain 247
Index 000
This cutting-edge, interdisciplinary volume describes established and state of the art approaches for exploring the pathways that influence and control appetite, including: behavioural, electrophysiological, neuroanatomical, gene knockout and pharmacological techniques. The book presents key peptide and neurotransmitter systems, together with newly emerging concepts of metabolic signalling and hypothalamic inflammation. The impact of early life experience on neuroendocrine appetite circuits is also looked at, including early programming of these circuits by circulating hormones. Finally, new emerging therapeutic approaches to appetite suppression are discussed, including those linked to bariatric (weight loss) surgery.
Neuroendocrinology of Appetite is especially focused on established and emerging technologies and approaches for investigating appetite control. It is written so as to provide an overview of sufficient depth for an undergraduate or new scientist in the field to come up to speed in the complementary approaches used by researchers in this field. Taking an interdisciplinary approach, the book aims to appeal to all those with a basic, clinical or therapeutic interest in research into obesity and eating disorders.
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