NEUROIMAGING DIAGNOSIS FOR ALZHEIMER´S DISEASE AND OTHER DEMENTIAS

1. Epidemiology of Dementia in Japan
2. Diagnostic Criteria for Alzheimer’s Disease
3. Structural Neuroimaging in Alzheimer’s Disease
4. MRI Diagnosis in Other Dementias
5. Diffusion Tensor Imaging in Dementia
6. Arterial Spin Labeling in Dementia
7. Proton Magnetic Resonance Spectroscopy for Dementia
8. Toward Clinical Application of Resting-State Functional Magnetic Resonance Imaging to Dementia
9. FDG-PET in Alzheimer’s Disease
10. Tau PET in Neurodegenerative Diseases Manifesting Dementia
11. Brain Perfusion SPECT in Alzheimer’s Disease
12. Neuroimaging of Dementia with Lewy Bodies
13. Neuroimaging of Frontotemporal Lobe Degeneration
14. Neuroimaging Study of Alzheimer’s Disease in Volunteer-Based Cohort
15. Handling of MRI Data in a Multicenter Study
16. Standardization and Quality Control of Brain PET Data in a Multicenter Study

This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer’s disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan. The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields.

Features
• Describes the latest modalities for diagnosis of Alzheimer’s disease and other dementias
• Provides information on handling and analyzing imaging data for dementia
• Includes routine imaging studies in the management of dementia

Author
Hiroshi Matsuda Integrative Brain Imaging Center, National Center of Neurology and Psychiatry Takashi Asada Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba Aya Midori Tokumaru Department of Diagnostic Radiology, Tokyo Metropolitan Medical Centre of Gerontology