NEUROPROTECTIVE NATURAL PRODUCTS: CLINICAL ASPECTS AND MODE OF ACTION

1 Neuroprotective Natural Products: Clinical Aspects and Modes of Action – An Overview 1
2 Neuroprotective Agents: An Overview on the General Modes of Action 7
3 Beneficial Upshots of Naturally Occurring Antioxidant Compounds against Neurological Disorders 23
4 Natural Neuroprotectives for the Management of Parkinson’s Disease 57
5 Neuroprotective Effect of Ayurvedic Preparations and Natural Products on Parkinson’s Disease 91
6 Lipid Peroxidation and Mitochondrial Dysfunction in Alzheimer’s and Parkinson’s Diseases: Role of Natural Products as Cytoprotective Agents 107
7 Marine-Derived Anti-Alzheimer’s Agents of Promise 153
8 Natural Products against Huntington’s Disease (HD): Implications of Neurotoxic Animal Models and Transgenics in Preclinical Studies 185
9 Possible Role of Neuroprotectants and Natural Products in Epilepsy: Clinical Aspects and Mode of Action 247
10 Neuroprotective Effects of Flavonoids in Epilepsy 279
11 The Role of Noncompetitive Antagonists of the N-Methyl-d-aspartate (NMDA) Receptors in Treatment-Resistant Depression 293
12 Safety and Efficacy of Ashwagandha (Withania somnifera) 313
13 Cannabinoids: A Group of Promising Neuroprotective Agents 321

Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases.
To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine.
With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.