List of contributors
Introduction: Why do we need Omics and Systems Biology
A Pregnancy Complications: Setting the Scene
1. The Mother: Adaptation to Pregnancy and normal metabolism
2. Maternal and fetal normal and abnormal nutrition
3. The Great Obstetrical Syndromes: It's all in the placenta
4. Embryo-specific communication and interaction with the maternal environment: The role of PreImplantation Factor
5. Normal and abnormal fetal growth
6. Pre-term labor and birth
7. Gestational Diabetes Mellitus
9. Maternal obesity
10. Maternal health: Immediate, short-, and long-term complications following pregnancy
11. The fetus and the neonate: Immediate, short, and long term impact
12. The cost of pregnancy complications related to non-communicable diseases and the cost effectiveness of interventions to address them
B Towards Prediction and Prevention
13. Integrated System Biology approaches to Fetal Medicine problems
14. Omics and female reproduction
15. The maternal genome and pregnancy outcomes
16. Placental development and Omics
17. Placental metabolomics in obese pregnancies
18. The methylome and epigenetics markers
19. The microbiome and pregnancy complications
20. Small non-coding RNAs as biomarkers for pregnancy complications
21. Urine metabolomics and proteomics in prenatal health
22. The metabolomics and perinatal complications
23. Metabolomics in normal and pathologic pregnancies
24. Metabolomics in amniotic fluid
25. Omics and coagulation disorders in pregnancy
26. The omics and preeclampsia
27. Single Nucleotide Polymorphisms and pregnancy complications
28. Metabolomics and perinatal cardiology
29. Metabolomics and human breast milk: a unique and inimitable food for infants
30. Neurodevelopment and placental omics
31. Early life complications, placental genomics, and the risk for neurodevelopmental disorders in the offspring
32. Metabolomics and perinatal asphyxia
33. Environment, pregnancy complications, and omics
34. Sleep and pregnancy complications
35. Maternal plasma cell-free DNA screening: I. Basic science and applications
36. Maternal plasma cell-free DNA screening: II. Integration into clinical practice
38. Whole exome and whole genome sequencing
The potential impact of work being conducted in genomics, proteomics, and metabolomics upon clinical practice for gynecologists is immense but not yet completely appreciated. This groundbreaking text from international experts examines the newest topics on the perinatal agenda and gives clinicians a real look into the future via the newest methodologies.
• Prof. Moshe Hod is Director of the Mor Comprehensive Women's Health Care Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel, President of the European Association of Perinatal Medicine, and Chairman of the FIGO Hyperglycemia in Pregnancy Working Group.
• Eduard Gratacos is Head and Professor of Maternal-Fetal Medicine at Hospitals Clínic de Barcelona & Sant Joan de Déu, Barcelona, Spain.
• Vincenzo Berghella is Professor and Director, Division of Maternal-Fetal Medicine at Thomas Jefferson University, Philadelphia, PA, USA, and President of the Society for Maternal-Fetal Medicine.
• Mary E D'Alton is Willard C. Rappleye Professor of Obstetrics & Gynecology and Director of Services, Sloane Hospital for Women, and Chair of the Department of Obstetrics & Gynecology, Maternal-Fetal Medicine, Columbia University Medical Center, New York, NY, USA, and is a past president of the Society for Maternal-Fetal Medicine.
• Prof. Gian Carlo Di Rezo is Director of Perinatal and Reproductive Medicine Center and Midwifery School, University Hospital Perugia, Italy and Director of Permanent International and European School of Perinatal and Reproductive Medicine, Florence, Italy.
• Prof. Vassilios Fanos is Professor of Pediatrics and Director of Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy.